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Microorganisms
Volume 8
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10.3390/microorganisms8050670
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Review

The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery

by
Md Jalal Uddin
1,†,
Jirapat Dawan
1,†,
Gibeom Jeon
1,
Tao Yu
2,
Xinlong He
3,* and
Juhee Ahn
1,*
1
Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Korea
2
Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining 272033, China
3
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2020, 8(5), 670; https://doi.org/10.3390/microorganisms8050670
Submission received: 29 March 2020 / Revised: 25 April 2020 / Accepted: 2 May 2020 / Published: 5 May 2020
(This article belongs to the Special Issue Control and Detection of Multiple Antibiotic Resistant Pathogens)
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Abstract

The rapid emergence and spread of antibiotic-resistant bacteria continues to be an issue difficult to deal with, especially in the clinical, animal husbandry, and food fields. The occurrence of multidrug-resistant bacteria renders treatment with antibiotics ineffective. Therefore, the development of new therapeutic methods is a worthwhile research endeavor in treating infections caused by antibiotic-resistant bacteria. Recently, bacterial membrane vesicles (BMVs) have been investigated as a possible approach to drug delivery and vaccine development. The BMVs are released by both pathogenic and non-pathogenic Gram-positive and Gram-negative bacteria, containing various components originating from the cytoplasm and the cell envelope. The BMVs are able to transform bacteria with genes that encode enzymes such as proteases, glycosidases, and peptidases, resulting in the enhanced antibiotic resistance in bacteria. The BMVs can increase the resistance of bacteria to antibiotics. However, the biogenesis and functions of BMVs are not fully understood in association with the bacterial pathogenesis. Therefore, this review aims to discuss BMV-associated antibiotic resistance and BMV-based therapeutic interventions.
Keywords: outer membrane vesicle; antibiotic resistance; virulence; vaccine; therapeutic agent delivery outer membrane vesicle; antibiotic resistance; virulence; vaccine; therapeutic agent delivery

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MDPI and ACS Style

Uddin, M.J.; Dawan, J.; Jeon, G.; Yu, T.; He, X.; Ahn, J. The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery. Microorganisms 2020, 8, 670. https://doi.org/10.3390/microorganisms8050670

AMA Style

Uddin MJ, Dawan J, Jeon G, Yu T, He X, Ahn J. The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery. Microorganisms. 2020; 8(5):670. https://doi.org/10.3390/microorganisms8050670

Chicago/Turabian Style

Uddin, Md Jalal, Jirapat Dawan, Gibeom Jeon, Tao Yu, Xinlong He, and Juhee Ahn. 2020. "The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery" Microorganisms 8, no. 5: 670. https://doi.org/10.3390/microorganisms8050670

APA Style

Uddin, M. J., Dawan, J., Jeon, G., Yu, T., He, X., & Ahn, J. (2020). The Role of Bacterial Membrane Vesicles in the Dissemination of Antibiotic Resistance and as Promising Carriers for Therapeutic Agent Delivery. Microorganisms, 8(5), 670. https://doi.org/10.3390/microorganisms8050670

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