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Microorganisms
Volume 9
Issue 12
10.3390/microorganisms9122492
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Article

Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice

by
Hang Guo
1,2,
Leilei Yu
1,2,
Fengwei Tian
1,2,
Jianxin Zhao
1,2,
Hao Zhang
1,2,3,4,
Wei Chen
1,2,3 and
Qixiao Zhai
1,2,*
1
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
2
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
3
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
4
Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi 214122, China
*
Author to whom correspondence should be addressed.
Microorganisms 2021, 9(12), 2492; https://doi.org/10.3390/microorganisms9122492
Submission received: 14 November 2021 / Revised: 26 November 2021 / Accepted: 29 November 2021 / Published: 1 December 2021
(This article belongs to the Section Veterinary Microbiology)
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Abstract

Antibiotic-associated diarrhea (AAD) is a self-limiting disease mediated by antibiotic therapy. In clinical practice, several types of probiotics are used in treating AAD, but minimal research has been done on Bacteroides-based microecologics. Our aim was to evaluate the therapeutic effects of Bacteroidetes uniformis FGDLZ48B1, B. intestinalis FJSWX61K18, Bifidobacterium adolescentis FHNFQ48M5, and B. bifidum FGZ30MM3 and their mixture on AAD in mice. The lincomycin hydrochloride-induced AAD models were gavaged with a single strain or a probiotic mixture for a short period to assess the changes in colonic histopathology and cytokine concentrations, intestinal epithelial permeability and integrity, short-chain fatty acids (SCFAs), and the diversity of intestinal microbiota. Our data indicated that both the sole use of Bacteroides and the combination of Bacteroides and Bifidobacterium beneficially weakened systemic inflammation, increased the recovery rate of tissue structures, increased the concentrations of SCFAs, and restored the gut microbiota. Moreover, the probiotic mixture was more effective than the single strain. Specifically, B. uniformis FGDLZ48B1 combined with the B. adolescentis FHNFQ48M5 group was more effective in alleviating the pathological features of the colon, downregulating the concentrations of interleukin (IL)-6, and upregulating the expression of occludin. In summary, our research suggests that administration of a mixture of B. uniformis FGDLZ48B1 and B. adolescentis FHNFQ48M5 is an effective approach for treating AAD.
Keywords: Bacteroides; Bifidobacterium; AAD; mice Bacteroides; Bifidobacterium; AAD; mice

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MDPI and ACS Style

Guo, H.; Yu, L.; Tian, F.; Zhao, J.; Zhang, H.; Chen, W.; Zhai, Q. Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice. Microorganisms 2021, 9, 2492. https://doi.org/10.3390/microorganisms9122492

AMA Style

Guo H, Yu L, Tian F, Zhao J, Zhang H, Chen W, Zhai Q. Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice. Microorganisms. 2021; 9(12):2492. https://doi.org/10.3390/microorganisms9122492

Chicago/Turabian Style

Guo, Hang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, and Qixiao Zhai. 2021. "Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice" Microorganisms 9, no. 12: 2492. https://doi.org/10.3390/microorganisms9122492

APA Style

Guo, H., Yu, L., Tian, F., Zhao, J., Zhang, H., Chen, W., & Zhai, Q. (2021). Effects of Bacteroides-Based Microecologics against Antibiotic-Associated Diarrhea in Mice. Microorganisms, 9(12), 2492. https://doi.org/10.3390/microorganisms9122492

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