Sedation Quality and Cardiorespiratory, Echocardiographic, Radiographic and Electrocardiographic Effects of Intramuscular Alfaxalone and Butorphanol in Spanish Greyhound Dogs

Round 1

Reviewer 1 Report

The study is interesting and certainly a contribution to veterinarians in routine clinical practice, therefore I suggest inserting and commenting on the following bibliographic notes even if it concerns the use of alfaxan and butorphanol in other animal species:

DOI 10.5152/actavet.2021.20041

DOI 10.1111/eve.13040

DOI 10.1016/j.vaa.2018.08.006

 

Interlandi C., Leonardi F., Spadola F., Costa G. L. (2021). Evaluation Of The Paw Withdrawal Latency For The Comparison Between Tramadol And Butorphanol Administered Locally, In The Plantar Surface Of Rat, Preliminary Study. Plos One, P. 2-8, ISSN: 1932-6203, Doi: 10.1371

Leonardi F, Costa G, Stagnoli A, Zubin E, Boschi P, Sabbioni A, Simonazzi B. (2019). The Effect Of Intramuscular Dexmedetomidine-Butorphanol Combination On Tear Production In Dogs. Canadian Veterinary Journal, vol. 60, p. 55-59, ISSN: 0008-5286

Claudia, Interlandi, Gioacchino, Calapai, Bernadette, Nastasi, Carmen, Mannucci, Manuel, Morici, Giovanna L. , Costa (2017). Effects of Atipamezole on the Analgesic Activity of Butorphanol in Rats. JOURNAL OF EXOTIC PET MEDICINE, vol. 26, p. 290-293, ISSN: 1557-5063, doi: DOI: http://dx.doi.org/10.1053/j.jepm.2017.07.001

Line 125 how many observers were assigned the sedation score. Declare the agreement between them W.

Line 186 Describe sedation in more detail by quality and duration. I recommend including a table as well.

Line 185 Declare sample power and data distribution.

 

 Minor editing of English language required

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Dear Author/s

It has been a pleasure to me reading your manuscript. Although it is a good article, there are few changes that must be corrected for further publication:

Please change "Galgo Español" for "spanish greyhound", or if you prefer in "italics". Check the whole manuscript.

Abstract - Line 41 - change x-rays for radiographic images

Introduction

Lines from 74 to 80 - Lack of literature in the paragraph:

https://doi.org/10.1292/jvms.15-0159
https://doi.org/10.2460/ajvr.81.1.65
https://doi.org/10.1292/jvms.20-0330
https://doi.org/10.1292/jvms.15-0065

Lines 79 to 80 - "has not been studied" which effects has not been studied?in all species?in dogs? are you sure for it?

Statistical analysis - Lines 173 to 176 - why did you calculate with BP values? why ecocardiographic findings were not used? If you use them, how much is your sample size?

Discussion - Line 231 - "the first one to measure cardiorespiratory and sedative effects.." this is not true, there are a couple of previous references (https://doi.org/10.1292/jvms.20-0330; https://doi.org/10.1292/jvms.15-0159)

Conclusions . Line 338 . either you follow "mg kg-1" or "mg/kg", please check author's guidelines for it.

Regards

Overall good quality of English

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

thank you for an interesting paper.

A couple of questions- did any of the side effects require treatment?

Do you recommend giving the drug combination a 30 minutes onset time for the best effects when given IM.

It may be helpful to have your sedation scales as an appendix so we can see the actual parameters measured and their value.

You recommend this drug combination for heart echo with minimal effect on the cardiovascular system?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Dear author, I saw that you followed my recommendations and your answers are satisfactory.

Reviewer 2 Report

Dear Author/s

Thank you for the changes you have done in your manuscript, and I consider it ready for its publication.

Kind regards

Reviewer 3 Report

the authors have addressed my concerns