Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Tissue Models
2.2. Tissue Dynamics
2.3. Material Model
2.4. Computational Simulations
3. Results
3.1. Tissue Strains
3.2. Sensitivity of Respiratory Mechanics Parameters
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Parameters | Bronchiole Tissue (G20) | |
50-year-old | 80-year-old | |
Lumen diameter (mm) | 0.45 | 0.32 |
Epithelium thickness (mm) | 0.011 | 0.015 |
Lamina propria (mm) | 0.056 | 0.073 |
Smooth muscle (mm) | 0.016 | 0.021 |
Alveolar sac tissue (G23) | ||
50-year-old | 80-year-old | |
Alveolus diameter (mm) | 0.25 | 0.54 |
Alveolar tissue thickness (mm) | 0.025 | 0.049 |
Initial Shear Modulus (Pa) | ||||
---|---|---|---|---|
Epithelium | Lamina Propria | Smooth Muscle | ||
50-year-old [33,36,37] | Bronchiole (G20) | 112,000 | 145,600 | 160,000 |
Alveolar sac (G23) | 35,714 | 46,428 | 51,000 | |
80-year-old [33,38,39] | Bronchiole (G20) | 123,760 | 160,000 | 177,000 |
Alveolar sac (G23) | 39,464 | 51,300 | 56,400 |
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Kim, J.; Heise, R.L.; Reynolds, A.M.; Pidaparti, R.M. Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation. Med. Sci. 2017, 5, 21. https://doi.org/10.3390/medsci5040021
Kim J, Heise RL, Reynolds AM, Pidaparti RM. Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation. Medical Sciences. 2017; 5(4):21. https://doi.org/10.3390/medsci5040021
Chicago/Turabian StyleKim, JongWon, Rebecca L. Heise, Angela M. Reynolds, and Ramana M. Pidaparti. 2017. "Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation" Medical Sciences 5, no. 4: 21. https://doi.org/10.3390/medsci5040021