Anthropometric Characteristics of Polycystic Ovary Syndrome and Their Associations with Insulin Resistance and Lipid Profile

Round 1

Reviewer 1 Report

In this paper Sanchez-Ferrer et al. studied association between polycystic syndrome (PCOS) and insulin resistance and lipid profile. Authors showed women with PSOD have higher body mass index and fat mass. PCOS is not always associated with increased plasma lipids. This study highlights the importance of considering body mass to asses PSOC. I think study is well conducted and recommend for publication.

Author Response

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Reviewer 2 Report

In the work of Sanchez-Ferrer et al., the authors evaluated anthropometric characteristics of polycystic ovary syndrome and their associations with insulin resistance and lipid profile. The work seems to be quite comprehensive with well-presented results. Unfortunately, it lacks novelty or the novelty has not been highlighted in the manuscript. 

How is this study different from those already published? What is the new knowledge we gain from this research? What is the impact of these analyses on the PCOS research/diagnosis/management?

Author Response

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Reviewer 3 Report

In the article “Anthropometric characteristics of polycystic ovary syndrome and their associations with insulin resistance and lipid profile” the authors tried to elucidate predictors of insulin resistance and lipid profile in PCOS and controls.

Comments:

1. The authors should emphasize the aspects of the study that are novel compared to previous studies and include a comment on that in the Discussion.
2. The authors mostly included older references, an update with articles published within the last 5 years would be required.
3. Figure 1 describing the methods is missing.
4. Why did the authors measure only testosterone? Are any data on other hormones available?
5. The authors should expand the section on the limitations of the study, mentioning for example age difference among cases and controls.
6. Table 1: include the explanation of the abbreviation POM.

Author Response

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Round 2

Reviewer 3 Report

The authors responded to all comments raised by the reviewers and provided more detailed explanations, improving the manuscript. The authors also updated the references and emphasized the novelty of the study.

Please check the formatting of Table 1 and 2.