The Relationship between Mitochondria and Neurodegeration in the Eye: A Review

Round 1

Reviewer 1 Report

The abstract was well described. However, there are several inconsistencies after the abstract. There are inconsistencies in how citations are cited throughout the article, e.g., [13] [14]; [8,9], [28, 30, 31], etc. also, several gaps are missing after or before full stops and citation. This might be a software download issue, but it appears it's an editing issue to me. I recommend revising all the citations for consistency.

Some sentences do not make sense or were run over. for example, lines 129 - 130 read, "Aging is a progressive that is time-related accumulation of 129 changes, responsible for involved in the increased susceptibility to disease [40-43]. With ..." It appears something is missing after progressive.

Line 133-134: "Some studies have proved that there is a close relationship between aging and mitochondrial dysfunction. Mistaking mitochondrial DNA replication ..." consider

"Some studies have shown that there is a close relationship between aging and mitochondrial dysfunction. Mistake in mitochondrial DNA replication ..." 

line 226 - 229: "The endogenous and exogenous agent can break integrity of the mitochondrial genome, the ROS is
the most important endogenous source of mtDNA damage, and it lead to mtDNA damage more extensive than nuclear DNA damage[39]." Consider clarifying "The" at the beginning of the sentences. Is ROS the exogenous and endogenous agent? "It lead" or "it leads". review the sentence for clarity or grammar.

Line 246 - 247: "ND5 is involved in the proton pump mechanism. Thus, mutations in ND5 may inhibit the activity of complex I, leading to oxidative stress [78]." What is ND5? This abbreviation comes out of nowhere without an introduction. There are other places in the paper with a similar issue for example; lines 383 - 384, 411, 414 - 415.

Lines 383 -384: "Free radical scavengers TEMPOL and MnTBAP inhibited 6-OHDA-induced autophagy activation. It has a protective effect on mitochondria[167]." The sentence is unclear. what is "it"? TEMPOL, MnTBAP was not explained.

Line 294: "increasing phosphorylation of Bad at serine 112 in the retina." What is Bad or is it BAD? consider introducing the abbreviation.

Author Response

Dear Reviewer,

Thank you very much for your valuable comments.

I have revised the article according to your opinion (attachment).

Have a nice day!

Many Thanks

Author Response File: Author Response.docx

Reviewer 2 Report

The review thoroughly discussed the role of mitochondrial dysfunction in AMD and other related retinal degenerative diseases. While the review is interesting and informative, I think there are some aspects that will make the review more interesting to read and information can readily be accessed from it.

• Some portion of the review is very lengthy and little bit boring in reading, specially 3.1 and 3.2. I suggest if the information can be re-written in more compact way and information can be given by introducing table or chart, it will be better to follow.
• Similarly genetic involvement of retinal degeneration can also be represented by table. References also should be given in the table.
• I also think authors should use one or two schematic representation of the mechanisms they explained in this review paper. This will not only enrich this review, but also make it easier to follow.
• During reading I find many problems in English writing, incomplete sentences etc. I suggest extensive editing by native English editor.
• The title of the review is little mis-leading. Authors only explain neurodegeneration related to eyes and optic nerves. Since mitochondrial dysfunction is also important in manifestation in neurodegenerative diseases, I suggest to change the title to avoid the confusions.

Author Response

Dear Reviewer,

Thank you very much for your valuable comments.

I have revised the article according to your opinion (attachment).

Have a nice day!

Many Thanks.

 

Response to Reviewer 2 Comments

 

Dear reviewer, thank you very much for your valuable comments.

 

Point 1: Some portion of the review is very lengthy and little bit boring in reading, specially 3.1 and 3.2. I suggest if the information can be re-written in more compact way and information can be given by introducing table or chart, it will be better to follow.

 

Response 1: Sections 3.1 and 3.2 are indeed a bit lengthy, because these two sections introduce the relationship between mitochondrial dysfunction and aging as a whole, as well as the influence of increased intraocular pressure on mitochondrial dysfunction. The following is the relationship between mitochondrial dysfunction and glaucoma. A foreshadowing. As you said, mitochondrial dysfunction plays an important role in neurodegenerative diseases, in order not to miss the theoretical introduction of mitochondria, aging and increased intraocular pressure, and to increase the interest of readers. We are professional English editing, and also added two pictures to explain the related mechanism, hope you can agree.

 

Point 2: Similarly genetic involvement of retinal degeneration can also be represented by table. References also should be given in the table.

 

Response 2: Using tables to express genes involved in retinal degeneration would be more vivid, but this review mainly reviews the relationship between mitochondrial dysfunction and neurodegenerative diseases, and then explains the role of mitochondria in ocular neurodegenerative diseases. Gene participation is only one part of it. With the limitation of the length of the article and the overall structure, the table is not included in this article. We are preparing another article on genetics and ocular degenerative diseases. In the next article, we will definitely absorb your valuable opinions and explain it in the relevant table. I hope you can agree.

 

Point 3: I also think authors should use one or two schematic representation of the mechanisms they explained in this review paper. This will not only enrich this review, but also make it easier to follow.

 

Response 3：Thank you very much for your valuable suggestions. We have added two mechanism diagrams to this article to enrich the content of the article.

 

Point 4: During reading I find many problems in English writing, incomplete sentences etc. I suggest extensive editing by native English editor.

 

Response 4：Thank you very much for your valuable comments. Our article was edited by a professional editor provided by MDPI for the English grammar in the article.

 

Point 5: The title of the review is little mis-leading. Authors only explain neurodegeneration related to eyes and optic nerves. Since mitochondrial dysfunction is also important in manifestation in neurodegenerative diseases, I suggest to change the title to avoid the confusions.

 

Response 5：Due to your valuable suggestions, after some analysis, in order to avoid reader confusion, while being able to express the content of the article and meet the requirements of the journal, we decided to modify the title：The relationship between mitochondria and neurodegeration in the：A review.

Author Response File: Author Response.docx