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Applied Sciences
Volume 13
Issue 2
10.3390/app13021081
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Background:
Brief Report

Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin

by
Junho Jung
1,
Minah Kim
1,2,
So-Woon Kim
3 and
Joo-Young Ohe
1,*
1
Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea
2
Department of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea
3
Department of Pathology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
*
Author to whom correspondence should be addressed.
Appl. Sci. 2023, 13(2), 1081; https://doi.org/10.3390/app13021081
Submission received: 6 December 2022 / Revised: 6 January 2023 / Accepted: 12 January 2023 / Published: 13 January 2023
(This article belongs to the Special Issue Advances in Maxillofacial and Oral Surgery)
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Abstract

Phosphaturic mesenchymal tumor (PMT) is strongly related to tumor-induced osteomalacia (TIO) which brings diverse skeletal events, such as bony deformities, gait disturbance, and multiple bone fractures. Overexpressed fibroblast growth factor 23 by the tumor induces hypophosphatemia leading to the oncogenic osteomalacia, a rare paraneoplastic syndrome. PMT occurring in the oral and maxillofacial regions is extremely rare, and this case highlights the need to understand mechanisms by which local lesions can affect systemic conditions, and the importance of a combination of physical examinations, laboratory investigations, and radiologic investigations for a decisive diagnosis.
Keywords: phostphaturic mesenchymal tumor; osteomalacia phostphaturic mesenchymal tumor; osteomalacia

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MDPI and ACS Style

Jung, J.; Kim, M.; Kim, S.-W.; Ohe, J.-Y. Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin. Appl. Sci. 2023, 13, 1081. https://doi.org/10.3390/app13021081

AMA Style

Jung J, Kim M, Kim S-W, Ohe J-Y. Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin. Applied Sciences. 2023; 13(2):1081. https://doi.org/10.3390/app13021081

Chicago/Turabian Style

Jung, Junho, Minah Kim, So-Woon Kim, and Joo-Young Ohe. 2023. "Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin" Applied Sciences 13, no. 2: 1081. https://doi.org/10.3390/app13021081

APA Style

Jung, J., Kim, M., Kim, S.-W., & Ohe, J.-Y. (2023). Tumor-Induced Osteomalacia as a Result of a Phosphaturic Mesenchymal Tumor: Detecting Rare Origin. Applied Sciences, 13(2), 1081. https://doi.org/10.3390/app13021081

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