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Volume 13
Issue 4
10.3390/app13042667
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Review

Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer

by
Francisco Quiñonero
1,2,3,
Cristina Mesas
1,2,3,
Mercedes Peña
1,2,3,
Laura Cabeza
1,2,3,
Gloria Perazzoli
1,2,3,
Consolación Melguizo
1,2,3,*,
Raul Ortiz
1,2,3,† and
Jose Prados
1,2,3,†
1
Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain
2
Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, 18071 Granada, Spain
3
Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18014 Granada, Spain
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Appl. Sci. 2023, 13(4), 2667; https://doi.org/10.3390/app13042667
Submission received: 13 December 2022 / Revised: 15 February 2023 / Accepted: 17 February 2023 / Published: 19 February 2023
(This article belongs to the Special Issue Potential Health Benefits of Fruits and Vegetables II)
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Abstract

Colorectal cancer is one of the leading causes of morbidity and mortality today. Knowledge of its pathogenesis has made it possible to advance the development of different therapeutic strategies. However, the appearance of drug resistance constitutes one of the main causes of treatment failure. Bioactive compounds of vegetable origin are being studied as a new strategy to improve antitumor treatment, due to their ability to regulate the pathways involved in the development of carcinogenesis or processes that are decisive in its evolution, including multidrug resistance. In vitro and in vivo studies of these substances in combination with cytotoxic drugs have shown that they reduce resistance and increase therapeutic efficacy. The objective of this review is to summarize the knowledge that is described in the scientific literature on the antitumor and chemo-sensitizing capacity of vegetable-derived biomolecules such as polyphenols, flavonoids, and terpenes. These compounds may hold a promising future in improving the treatment of colorectal cancer.
Keywords: colorectal cancer; vegetables; multidrug resistance; biomolecules; resistance mechanisms colorectal cancer; vegetables; multidrug resistance; biomolecules; resistance mechanisms

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MDPI and ACS Style

Quiñonero, F.; Mesas, C.; Peña, M.; Cabeza, L.; Perazzoli, G.; Melguizo, C.; Ortiz, R.; Prados, J. Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer. Appl. Sci. 2023, 13, 2667. https://doi.org/10.3390/app13042667

AMA Style

Quiñonero F, Mesas C, Peña M, Cabeza L, Perazzoli G, Melguizo C, Ortiz R, Prados J. Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer. Applied Sciences. 2023; 13(4):2667. https://doi.org/10.3390/app13042667

Chicago/Turabian Style

Quiñonero, Francisco, Cristina Mesas, Mercedes Peña, Laura Cabeza, Gloria Perazzoli, Consolación Melguizo, Raul Ortiz, and Jose Prados. 2023. "Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer" Applied Sciences 13, no. 4: 2667. https://doi.org/10.3390/app13042667

APA Style

Quiñonero, F., Mesas, C., Peña, M., Cabeza, L., Perazzoli, G., Melguizo, C., Ortiz, R., & Prados, J. (2023). Vegetal-Derived Bioactive Compounds as Multidrug Resistance Modulators in Colorectal Cancer. Applied Sciences, 13(4), 2667. https://doi.org/10.3390/app13042667

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