Next Article in Journal
Ultimate Support Pressure Determination for Shield Tunnel Faces in Saturated Strata Based on Seepage Flow Control
Previous Article in Journal
Impact of Classical Music Listening on Cognitive and Functional Performances in Middle-Aged Women
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Research Progress in the Construction and Application of In Vitro Vascular Models

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Appl. Sci. 2024, 14(15), 6780; https://doi.org/10.3390/app14156780
Submission received: 27 June 2024 / Revised: 30 July 2024 / Accepted: 1 August 2024 / Published: 3 August 2024

Abstract

The vascular system maintains cellular homeostasis by transporting oxygen, nutrients, and metabolic waste products. The vascular system is involved in a variety of fundamental physiological phenomena and is closely associated with human vascular diseases. Additionally, the stability of drugs in the vasculature affects their efficacy. Therefore, researchers have used vascular models to study vascular diseases, assess drug stability, and screen drugs. However, there are many shortcomings in the animal models and in vitro two-dimensional vascular models that have been extensively developed. In this paper, we specifically review the construction methods of in vitro vascular models and classify the specific methods into photolithography, soft lithography, self-assembly, template, 3D bioprinting, and laser degradation/cavitation. The first two are microfluidics-based methods and the last three are non-microfluidics-based methods. The vascular model construction methods reviewed in this paper overcome the shortcomings of traditional models—which cannot accurately reproduce the human vascular microenvironment—and can assist in the construction of in vitro 3D vascular models and tissue engineering vascularization. These models can be reused by perfusion devices, and the cells within the channels reside on biocompatible materials that are used to simulate the microenvironment and 3D cellular organization of the vasculature in vivo. In addition, these models are reproducible in shape and length, allowing experiments to be repeated, which is difficult to do with natural vessels. In vitro vascular models are widely used in research and drug screening for diseases associated with endothelial dysfunction, cancer, and other vascular abnormalities.
Keywords: angiogenesis; vasculogenesis; microfluidics; self-assembly; templating; 3D bioprinting angiogenesis; vasculogenesis; microfluidics; self-assembly; templating; 3D bioprinting

Share and Cite

MDPI and ACS Style

He, Z.; Cheng, P.; Ying, G.; Ou, Z. Research Progress in the Construction and Application of In Vitro Vascular Models. Appl. Sci. 2024, 14, 6780. https://doi.org/10.3390/app14156780

AMA Style

He Z, Cheng P, Ying G, Ou Z. Research Progress in the Construction and Application of In Vitro Vascular Models. Applied Sciences. 2024; 14(15):6780. https://doi.org/10.3390/app14156780

Chicago/Turabian Style

He, Zhenyu, Pengpeng Cheng, Guoqing Ying, and Zhimin Ou. 2024. "Research Progress in the Construction and Application of In Vitro Vascular Models" Applied Sciences 14, no. 15: 6780. https://doi.org/10.3390/app14156780

APA Style

He, Z., Cheng, P., Ying, G., & Ou, Z. (2024). Research Progress in the Construction and Application of In Vitro Vascular Models. Applied Sciences, 14(15), 6780. https://doi.org/10.3390/app14156780

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop