Sulfated Polysaccharides Isolated from Nacre Extract Suppress Chronic Scopolamine Administration-Induced Amyloid-Beta Deposition
Abstract
:1. Introduction
2. Methods
2.1. Materials
2.2. Preparation of the Nacre Extract and Sulfated Polysaccharides
2.3. Animals
2.4. Novel Object Recognition Test
2.5. Y-Maze Test
2.6. Histochemistry
2.7. RT-qPCR
2.8. Western Blot Analyses
2.9. Statistical Analyses
3. Results
3.1. Effect of Sulfated Polysaccharides on Chronic Scopolamine-Induced Memory Impairment
3.2. Effect of Sulfated Polysaccharides on Aβ Deposition
3.3. Effects of Sulfated Polysaccharides on Hippocampal Neurons
3.4. Effects of Sulfated Polysaccharide on the Aβ Metabolism-Associated Enzyme Levels
3.5. Effect of Sulfated Polysaccharides on Insulin Signaling
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wako, M.; Ohara, K.; Hasegawa, Y. Sulfated Polysaccharides Isolated from Nacre Extract Suppress Chronic Scopolamine Administration-Induced Amyloid-Beta Deposition. Appl. Sci. 2024, 14, 7830. https://doi.org/10.3390/app14177830
Wako M, Ohara K, Hasegawa Y. Sulfated Polysaccharides Isolated from Nacre Extract Suppress Chronic Scopolamine Administration-Induced Amyloid-Beta Deposition. Applied Sciences. 2024; 14(17):7830. https://doi.org/10.3390/app14177830
Chicago/Turabian StyleWako, Mayumi, Kanae Ohara, and Yasushi Hasegawa. 2024. "Sulfated Polysaccharides Isolated from Nacre Extract Suppress Chronic Scopolamine Administration-Induced Amyloid-Beta Deposition" Applied Sciences 14, no. 17: 7830. https://doi.org/10.3390/app14177830