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Volume 15
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10.3390/app15063254
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Article

Biological Activities of Selected Medicinal and Edible Plants Aqueous Infusions

by
Tea Bilušić
1,*,
Vedrana Čikeš Čulić
2,
Zoran Zorić
3,
Zrinka Čošić
4,
Lovorka Vujić
5 and
Ivana Šola
6
1
Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia
2
School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia
3
Department of Ecology and Agronomy, University of Zadar, Mihovila Pavlinovića 1, 23000 Zadar, Croatia
4
Faculty of Food Technology and Biotechnology, Centre in Zadar, University of Zagreb, P. Kasandrića 6, 23000 Zadar, Croatia
5
Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia
6
Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Appl. Sci. 2025, 15(6), 3254; https://doi.org/10.3390/app15063254
Submission received: 14 February 2025 / Revised: 10 March 2025 / Accepted: 13 March 2025 / Published: 17 March 2025
(This article belongs to the Special Issue Novel Research on Bioactive Compounds in Plant Products)
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Abstract

This study investigated the phenolic profile and biological activities (antioxidant, antimicrobial, anti-hyperglycemic and antiproliferative) of aqueous infusions prepared from the following medicinal and edible plants: Geranium macrorrhizum L., Verbascum thapsus L., Ononis spinosa L., Achillea millefolium L., and Polygonum aviculare L. Despite their long-term usage and numerous scientific results on various solvent extracts of selected plants, they are still un-explored in terms of certain aspects of in vitro biological activities, especially in the form of aqueous infusions, which are a very common form of consumption of medicinal plants. The phenolic analysis of the selected infusions was carried out using the HPLC-DAD method and showed the highest content of total phenols in G. macrorrhizum and P. aviculare, the highest total flavonoid content in P. aviculare, and a high content of procyanidins in G. macrorrhizum. The highest antioxidant activity according to the three methods (DPPH, FRAP and Rancimat) was achieved by G. macrorrhizum and A. millefolium. The aqueous infusions of the selected plants showed no antimicrobial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923. The highest anti-hyperglycemic activity by inhibition of the enzymes α-glucosidase and α-amylase and the highest antiproliferative activity against MD-MBA-231, A549 and T24 cells was obtained from G. macrorrhizum.
Keywords: antioxidant activity; antimicrobial activity; anti-hyperglycemic activity; antiproliferative activity; phenolic compounds; herbal infusions antioxidant activity; antimicrobial activity; anti-hyperglycemic activity; antiproliferative activity; phenolic compounds; herbal infusions

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MDPI and ACS Style

Bilušić, T.; Čulić, V.Č.; Zorić, Z.; Čošić, Z.; Vujić, L.; Šola, I. Biological Activities of Selected Medicinal and Edible Plants Aqueous Infusions. Appl. Sci. 2025, 15, 3254. https://doi.org/10.3390/app15063254

AMA Style

Bilušić T, Čulić VČ, Zorić Z, Čošić Z, Vujić L, Šola I. Biological Activities of Selected Medicinal and Edible Plants Aqueous Infusions. Applied Sciences. 2025; 15(6):3254. https://doi.org/10.3390/app15063254

Chicago/Turabian Style

Bilušić, Tea, Vedrana Čikeš Čulić, Zoran Zorić, Zrinka Čošić, Lovorka Vujić, and Ivana Šola. 2025. "Biological Activities of Selected Medicinal and Edible Plants Aqueous Infusions" Applied Sciences 15, no. 6: 3254. https://doi.org/10.3390/app15063254

APA Style

Bilušić, T., Čulić, V. Č., Zorić, Z., Čošić, Z., Vujić, L., & Šola, I. (2025). Biological Activities of Selected Medicinal and Edible Plants Aqueous Infusions. Applied Sciences, 15(6), 3254. https://doi.org/10.3390/app15063254

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