On-Line Tendency Control of Dissolved Oxygen Concentration during Aerobic Fed-Batch Fermentations
Abstract
:1. Introduction
2. Materials and Methods
2.1. Corynebacterium Glutamicum Fermentation
2.1.1. Fermentation Conditions
2.1.2. Analytical Methods
2.2. Pichia pastoris Fermentation
2.2.1. Microorganism and Fermentation Conditions
2.2.2. Analytical Methods
2.3. DO Control Model
2.3.1. DO Tendency Control Model
2.3.2. DO Control Algorithm
3. Results and Discussion
3.1. Performance during C. glutamicum Fermentation
3.1.1. DO Tendency Control in Cell Growth Phase
3.1.2. DO Tendency Control in Production Phase
3.2. Performance during P. pastoris Fermentation
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Different Methods | From 0 to 45 min |
---|---|
Manual control | 27 times |
Tendency control | 3 times |
Different Methods | From 1565 to 1609 min |
---|---|
Manual control | 27 times |
Tendency control | 2 times |
Different Methods | From 1220 to 1509 min |
---|---|
Manual control | 99 times |
Tendency control | 2 times |
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Zheng, R.; Pan, F. On-Line Tendency Control of Dissolved Oxygen Concentration during Aerobic Fed-Batch Fermentations. Appl. Sci. 2019, 9, 5232. https://doi.org/10.3390/app9235232
Zheng R, Pan F. On-Line Tendency Control of Dissolved Oxygen Concentration during Aerobic Fed-Batch Fermentations. Applied Sciences. 2019; 9(23):5232. https://doi.org/10.3390/app9235232
Chicago/Turabian StyleZheng, Rongjian, and Feng Pan. 2019. "On-Line Tendency Control of Dissolved Oxygen Concentration during Aerobic Fed-Batch Fermentations" Applied Sciences 9, no. 23: 5232. https://doi.org/10.3390/app9235232