Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder
Abstract
:1. Introduction
2. Methods
2.1. Dataset
2.2. Imputation Method
2.3. Assessment of Performance of the Imputation Method
2.3.1. Concordance Correlation Coefficient (CCC)
2.3.2. Predictive Accuracy and Linear Regression Model
2.3.3. Limits of Agreement and Bland–Altman Analysis
2.4. Meta-Analysis
3. Results
3.1. Responder Rates
3.2. Odds Ratios
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Agreement | Predictive Accuracy | Bias | |||||
---|---|---|---|---|---|---|---|
Number of Observations (k) | CCC (95% CI) | β (95% CI) of Original (Y) and Imputed (X) | R2 (%) | MSE | Bias and 95% Limits of Agreement | β (95% CI) of Difference (Y) and Mean (X) | |
Responder Rates (Original 58 Observations) | |||||||
Primary Threshold | 58 | 0.93 (0.89–0.96) | 1.04 (0.95, 1.13) | 90.86 | 0.063 | 4.32% (−8.1%, 16.74%) | −0.034 (−0.135, 0.068) * |
Secondary Threshold | 58 | 0.59 (0.48−0.69) | 1.41 (1.26, 1.57) | 85.01 | 0.0813 | 16.15% (−3.18%, 35.47%) | −0.028 (−0.177, 0.121) * |
Log OR (Original 30 Observations) | |||||||
Primary Threshold | 28 | 0.91 (0.81, 0.95) | 0.96 (0.78, 1.14) | 82.03% | 0.495 | 0.09 (−0.87, 1.04) | 0.06 (−0.120, 0.231) |
Secondary Threshold | 27 | 0.81 (0.63, 0.91) | 0.90 (0.65, 1.15) | 67.85% | 0.664 | 0.24 (−1.05, 1.53) | 0.086 (−0.164, 0.334) |
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Siafis, S.; Rodolico, A.; Çıray, O.; Murphy, D.G.; Parellada, M.; Arango, C.; Leucht, S. Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder. Brain Sci. 2021, 11, 908. https://doi.org/10.3390/brainsci11070908
Siafis S, Rodolico A, Çıray O, Murphy DG, Parellada M, Arango C, Leucht S. Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder. Brain Sciences. 2021; 11(7):908. https://doi.org/10.3390/brainsci11070908
Chicago/Turabian StyleSiafis, Spyridon, Alessandro Rodolico, Oğulcan Çıray, Declan G. Murphy, Mara Parellada, Celso Arango, and Stefan Leucht. 2021. "Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder" Brain Sciences 11, no. 7: 908. https://doi.org/10.3390/brainsci11070908
APA StyleSiafis, S., Rodolico, A., Çıray, O., Murphy, D. G., Parellada, M., Arango, C., & Leucht, S. (2021). Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder. Brain Sciences, 11(7), 908. https://doi.org/10.3390/brainsci11070908