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Brain Sciences, Volume 11, Issue 7

2021 July - 135 articles

Cover Story: Navigated transcranial magnetic stimulation (nTMS) has developed into a reliable non-invasive clinical and scientific tool over the past decade, being particularly used for motor mapping in patients with brain tumors. In this article, we review the evidence for the feasibility of motor mapping and derived models (risk stratification and prediction, nTMS-based fiber tracking, improvement of clinical outcome, and assessment of functional plasticity) and provide collected sets of evidence for the applicability of quantitative mapping with nTMS. In addition, we provide evidence-based demonstrations on factors that ensure methodological feasibility and accuracy of the motor mapping procedure. View this paper
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Articles (135)

  • Systematic Review
  • Open Access
10 Citations
3,248 Views
18 Pages

Purpose: The olfactory system is particularly vulnerable in an ageing brain, both anatomically and functionally, and these brain changes are more pronounced among individuals with trisomy 21. Furthermore, the age of the system starts to deteriorate,...

  • Article
  • Open Access
7 Citations
3,594 Views
15 Pages

Quality of Life and Psychological Distress in Portuguese Older Individuals with Tinnitus

  • Haúla F. Haider,
  • Sara F. Ribeiro,
  • Derek J. Hoare,
  • Graça Fialho,
  • Deborah A. Hall,
  • Marília Antunes,
  • Helena Caria and
  • João Paço

Tinnitus is the perception of a sound without an external source, often associated with adverse psychological and emotional effects leading to impaired quality of life (QoL). The present study investigated QoL and psychological distress in tinnitus p...

  • Review
  • Open Access
15 Citations
4,973 Views
12 Pages

Cofilin and Neurodegeneration: New Functions for an Old but Gold Protein

  • Tamara Lapeña-Luzón,
  • Laura R. Rodríguez,
  • Vicent Beltran-Beltran,
  • Noelia Benetó,
  • Federico V. Pallardó and
  • Pilar Gonzalez-Cabo

Cofilin is an actin-binding protein that plays a major role in the regulation of actin dynamics, an essential cellular process. This protein has emerged as a crucial molecule for functions of the nervous system including motility and guidance of the...

  • Article
  • Open Access
2 Citations
6,218 Views
14 Pages

Scent of a Woman—Or Man: Odors Influence Person Knowledge

  • Nicole L. Hovis,
  • Paul R. Sheehe and
  • Theresa L. White

First impressions of social traits are regularly, rapidly, and readily determined from limited information about another individual. Relatively little is known about the way that olfactory information, particularly from scents that are not body odors...

  • Article
  • Open Access
1 Citations
3,336 Views
12 Pages

Endogenous Expression of G-CSF in Rat Dorsal Root Ganglion Neurons after Nerve Injury

  • Chun-Chang Yeh,
  • Chih-Ping Yang,
  • Kuo-Hsing Ma,
  • Jui-Hu Shih,
  • Ching-San Tseng and
  • Yuahn-Sieh Huang

Granulocyte colony-stimulating factor (G-CSF) has been reported to modulate pain function following nerve injury. However, the expression of endogenous G-CSF in the dorsal root ganglion (DRG) and the response to nerve injury remain unclear. In the pr...

  • Article
  • Open Access
18 Citations
7,347 Views
19 Pages

Effects of Neurofeedback on the Working Memory of Children with Learning Disorders—An EEG Power-Spectrum Analysis

  • Benito J. Martínez-Briones,
  • Jorge Bosch-Bayard,
  • Rolando J. Biscay-Lirio,
  • Juan Silva-Pereyra,
  • Lucero Albarrán-Cárdenas and
  • Thalía Fernández

Learning disorders (LDs) are diagnosed in children impaired in the academic skills of reading, writing and/or mathematics. Children with LDs usually exhibit a slower resting-state electroencephalogram (EEG), corresponding to a neurodevelopmental lag....

  • Article
  • Open Access
12 Citations
3,640 Views
8 Pages

Minor Non-Disabling Stroke Patients with Large Vessel Severe Stenosis or Occlusion Might Benefit from Thrombolysis

  • Wansi Zhong,
  • Ying Zhou,
  • Kemeng Zhang,
  • Shenqiang Yan,
  • Jianzhong Sun and
  • Min Lou

Background: The benefit of alteplase in minor non-disabling acute ischemic stroke (AIS) is unknown. We aimed to explore the clinical efficacy of alteplase-treatment in minor non-disabling stroke in clinical practice. Methods: We used a prospectively...

  • Article
  • Open Access
15 Citations
3,927 Views
10 Pages

Transcranial Direct Current Stimulation (tDCS) for Depression during Pregnancy: Results from an Open-Label Pilot Study

  • Anna Katharina Kurzeck,
  • Esther Dechantsreiter,
  • Anja Wilkening,
  • Ulrike Kumpf,
  • Tabea Nenov-Matt,
  • Frank Padberg and
  • Ulrich Palm

Introduction: Depression is the most common morbidity during pregnancy. Available first-line therapy options are limited and depressive disorders in pregnant women are often untreated, leading to negative effects on maternal and fetal health. Objecti...

  • Article
  • Open Access
2,907 Views
11 Pages

Enhanced Expectation of External Sensations of the Chest Regulates the Emotional Perception of Fearful Faces

  • Won-Mo Jung,
  • In-Seon Lee,
  • Ye-Seul Lee,
  • Yeonhee Ryu,
  • Hi-Joon Park and
  • Younbyoung Chae

Emotional perception can be shaped by inferences about bodily states. Here, we investigated whether exteroceptive inferences about bodily sensations in the chest area influence the perception of fearful faces. Twenty-two participants received pseudo-...

  • Article
  • Open Access
3 Citations
5,498 Views
11 Pages

Oxcarbazepine for Behavioral Disorders after Brain Injury: Factors Influencing Efficacy

  • Marco Pozzi,
  • Paolo Avantaggiato,
  • Valentina Pastore,
  • Carla Carnovale,
  • Emilio Clementi and
  • Sandra Strazzer

Carbamazepine and oxcarbazepine are used for behavioral disorders following organic diseases. After severe acquired brain injury, patients may develop frontal symptoms. In our neurological rehabilitation routine, oxcarbazepine is used for better safe...

  • Article
  • Open Access
12 Citations
3,578 Views
18 Pages

Substance Use Outcomes from Two Formats of a Cognitive-Behavioral Intervention for Aggressive Children: Moderating Roles of Inhibitory Control and Intervention Engagement

  • John E. Lochman,
  • Caroline L. Boxmeyer,
  • Chuong Bui,
  • Estephan Hakim,
  • Shannon Jones,
  • Francesca Kassing,
  • Kristina McDonald,
  • Nicole Powell,
  • Lixin Qu and
  • Thomas Dishion

Although cognitive-behavioral interventions have reduced the risk of substance use, little is known about moderating factors in children with disruptive behaviors. This study examined whether aggressive preadolescents’ inhibitory control and interven...

  • Article
  • Open Access
10 Citations
5,494 Views
16 Pages

Episodic Memory Encoding and Retrieval in Face-Name Paired Paradigm: An fNIRS Study

  • Qian Yu,
  • Boris Cheval,
  • Benjamin Becker,
  • Fabian Herold,
  • Chetwyn C. H. Chan,
  • Yvonne N. Delevoye-Turrell,
  • Ségolène M. R. Guérin,
  • Paul Loprinzi,
  • Notger Mueller and
  • Liye Zou

Background: Episodic memory (EM) is particularly sensitive to pathological conditions and aging. In a neurocognitive context, the paired-associate learning (PAL) paradigm, which requires participants to learn and recall associations between stimuli,...

  • Systematic Review
  • Open Access
43 Citations
10,478 Views
82 Pages

Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review

  • Nicola Acevedo,
  • Peter Bosanac,
  • Toni Pikoos,
  • Susan Rossell and
  • David Castle

Invasive and noninvasive neurostimulation therapies for obsessive-compulsive and related disorders (OCRD) were systematically reviewed with the aim of assessing clinical characteristics, methodologies, neuroanatomical substrates, and varied stimulati...

  • Article
  • Open Access
9 Citations
4,049 Views
9 Pages

Brain Structural Connectivity Differences in Patients with Normal Cognition and Cognitive Impairment

  • Nauris Zdanovskis,
  • Ardis Platkājis,
  • Andrejs Kostiks,
  • Guntis Karelis and
  • Oļesja Grigorjeva

Advances in magnetic resonance imaging, particularly diffusion imaging, have allowed researchers to analyze brain connectivity. Identification of structural connectivity differences between patients with normal cognition, cognitive impairment, and de...

  • Article
  • Open Access
5 Citations
4,455 Views
15 Pages

Defining the relationship between vascular development and the expression of hypoxia-inducible factors (Hifs) and vascular endothelial growth factor (Vegf) in the auditory brainstem is important to understand how tissue hypoxia caused by oxygen short...

  • Article
  • Open Access
14 Citations
4,401 Views
13 Pages

Glutathione as a Molecular Marker of Functional Impairment in Patients with At-Risk Mental State: 7-Tesla 1H-MRS Study

  • Peter Jeon,
  • Roberto Limongi,
  • Sabrina D. Ford,
  • Cassandra Branco,
  • Michael Mackinley,
  • Maya Gupta,
  • Laura Powe,
  • Jean Théberge and
  • Lena Palaniyappan

A substantial number of individuals with clinical high-risk (CHR) mental state do not transition to psychosis. However, regardless of future diagnostic trajectories, many of these individuals develop poor social and occupational functional outcomes....

  • Article
  • Open Access
25 Citations
4,508 Views
19 Pages

Spatiotemporal Dynamics of Covert Versus Overt Processing of Happy, Fearful and Sad Facial Expressions

  • Antonio Maffei,
  • Jennifer Goertzen,
  • Fern Jaspers-Fayer,
  • Killian Kleffner,
  • Paola Sessa and
  • Mario Liotti

Behavioral and electrophysiological correlates of the influence of task demands on the processing of happy, sad, and fearful expressions were investigated in a within-subjects study that compared a perceptual distraction condition with task-irrelevan...

  • Article
  • Open Access
13 Citations
3,918 Views
17 Pages

Studying Brain Activation during Skill Acquisition via Robot-Assisted Surgery Training

  • Kurtulus Izzetoglu,
  • Mehmet Emin Aksoy,
  • Atahan Agrali,
  • Dilek Kitapcioglu,
  • Mete Gungor and
  • Aysun Simsek

Robot-assisted surgery systems are a recent breakthrough in minimally invasive surgeries, offering numerous benefits to both patients and surgeons including, but not limited to, greater visualization of the operation site, greater precision during op...

  • Article
  • Open Access
6 Citations
4,170 Views
11 Pages

Communicative abilities in infants with Down syndrome (DS) are delayed in comparison to typically developing (TD) infants, possibly affecting language development in DS. Little is known about what abilities might underlie poor communication and langu...

  • Article
  • Open Access
9 Citations
4,740 Views
20 Pages

Disrupted Functional Rich-Club Organization of the Brain Networks in Children with Attention-Deficit/Hyperactivity Disorder, a Resting-State EEG Study

  • Maliheh Ahmadi,
  • Kamran Kazemi,
  • Katarzyna Kuc,
  • Anita Cybulska-Klosowicz,
  • Mohammad Sadegh Helfroush and
  • Ardalan Aarabi

Growing evidence indicates that disruptions in the brain’s functional connectivity play an important role in the pathophysiology of ADHD. The present study investigates alterations in resting-state EEG source connectivity and rich-club organization i...

  • Article
  • Open Access
32 Citations
4,789 Views
15 Pages

Exome Sequencing in 200 Intellectual Disability/Autistic Patients: New Candidates and Atypical Presentations

  • Floriana Valentino,
  • Lucia Pia Bruno,
  • Gabriella Doddato,
  • Annarita Giliberti,
  • Rossella Tita,
  • Sara Resciniti,
  • Chiara Fallerini,
  • Mirella Bruttini,
  • Caterina Lo Rizzo and
  • Francesca Ariani
  • + 11 authors

Intellectual disability (ID) and autism spectrum disorder (ASD) belong to neurodevelopmental disorders and occur in ~1% of the general population. Due to disease heterogeneity, identifying the etiology of ID and ASD remains challenging. Exome sequenc...

  • Article
  • Open Access
14 Citations
6,733 Views
15 Pages

Personal and Environmental Predictors of Aggression in Adolescence

  • Claudia A. Robles-Haydar,
  • Marina B. Martínez-González,
  • Yuliana A. Flórez-Niño,
  • Luz M. Ibáñez-Navarro and
  • José J. Amar-Amar

This study aims to find causal factors of aggression in a group of Latino adolescents to achieve a greater understanding of human nature, taking into account personal and contextual variables. The fundamental hypothesis is that moral disengagement, p...

  • Article
  • Open Access
5 Citations
3,125 Views
11 Pages

Post-stroke spasticity frequently occurs in patients with stroke, and there is a need for more quality-of-life assessments for different therapies. We evaluated for the first time in Romania the quality of life among patients with post-stroke spastic...

  • Article
  • Open Access
2 Citations
4,551 Views
18 Pages

Working Memory Performance under a Negative Affect Is More Susceptible to Higher Cognitive Workloads with Different Neural Haemodynamic Correlates

  • Ying Xing Feng,
  • Masashi Kiguchi,
  • Wei Chun Ung,
  • Sarat Chandra Dass,
  • Ahmad Fadzil Mohd Hani,
  • Tong Boon Tang and
  • Eric Tatt Wei Ho

The effect of stress on task performance is complex, too much or too little stress negatively affects performance and there exists an optimal level of stress to drive optimal performance. Task difficulty and external affective factors are distinct st...

  • Article
  • Open Access
6 Citations
5,094 Views
21 Pages

Psychosocial Features of Shift Work Disorder

  • Annie Vallières,
  • Chantal Mérette,
  • Alric Pappathomas,
  • Monica Roy and
  • Célyne H. Bastien

To better understand Shift Work Disorder (SWD), this study investigates insomnia, sleepiness, and psychosocial features of night workers. The study compares night workers with or without SWD to day workers with or without insomnia. Seventy-nine night...

  • Article
  • Open Access
27 Citations
13,765 Views
13 Pages

Losing the Self in Near-Death Experiences: The Experience of Ego-Dissolution

  • Charlotte Martial,
  • Géraldine Fontaine,
  • Olivia Gosseries,
  • Robin Carhart-Harris,
  • Christopher Timmermann,
  • Steven Laureys and
  • Héléna Cassol

Many people who have had a near-death experience (NDE) describe, as part of it, a disturbed sense of having a “distinct self”. However, no empirical studies have been conducted to explore the frequency or intensity of these effects. We surveyed 100 N...

  • Case Report
  • Open Access
8 Citations
6,787 Views
11 Pages

Influence of Mirror Therapy (Specular Face Software) on Electromyographic Behavior of the Facial Muscles for Facial Palsy

  • Alfonso Gil-Martínez,
  • Sergio Lerma-Lara,
  • Alfredo Hernando-Jorge,
  • Ana Campos-Vegas,
  • Audrey Aceval,
  • Rafael Pagés-Scasso,
  • Francisco Morán-Burgos and
  • Hector Beltran-Alacreu

Introduction: Facial paralysis (FP) is a neuromuscular disorder caused by facial nerve injury. There are two main types of FP (which can be either primary or secondary): central and peripheral; Procedure of cases: This case series presents five patie...

  • Article
  • Open Access
10 Citations
3,831 Views
10 Pages

Expansion of the Genotypic and Phenotypic Spectrum of WASF1-Related Neurodevelopmental Disorder

  • Siddharth Srivastava,
  • Erica L. Macke,
  • Lindsay C. Swanson,
  • David Coulter,
  • Eric W. Klee,
  • Sureni V. Mullegama,
  • Yili Xie,
  • Brendan C. Lanpher,
  • Emma C. Bedoukian and
  • Julie S. Cohen
  • + 4 authors

In humans, de novo truncating variants in WASF1 (Wiskott–Aldrich syndrome protein family member 1) have been linked to presentations of moderate-to-profound intellectual disability (ID), autistic features, and epilepsy. Apart from one case series, th...

  • Case Report
  • Open Access
3 Citations
3,389 Views
5 Pages

Stiff-Eye Syndrome—Anti-GAD Ataxia Presenting with Isolated Ophthalmoplegia: A Case Report

  • Abel Dantas Belém,
  • Thaís de Maria Frota Vasconcelos,
  • Rafael César dos Anjos de Paula,
  • Francisco Bruno Santana da Costa,
  • Pedro Gustavo Barros Rodrigues,
  • Isabelle de Sousa Pereira,
  • Paulo Roberto de Arruda Tavares,
  • Gabriela Studart Galdino,
  • Daniel Aguiar Dias and
  • Paulo Ribeiro Nobrega
  • + 3 authors

Anti-GAD ataxia is one of the most common forms of immune-mediated cerebellar ataxias. Many neurological syndromes have been reported in association with anti-GAD. Ophthalmoparesis has been described in stiff person syndrome. We report a case of anti...

  • Article
  • Open Access
10 Citations
4,588 Views
15 Pages

Psychopathic Traits in Childhood: Insights from Parental Warmth and Fearless Temperament via Conscience Development

  • Laura López-Romero,
  • Olalla Cutrín,
  • Lorena Maneiro,
  • Beatriz Domínguez-Álvarez and
  • Estrella Romero

The role of psychopathic traits in predicting more serious and persistent patterns of child conduct problems has been well documented. The jointly presence of interpersonal (grandiose–deceitful), affective (e.g., callous–unemotional), and behavioral...

  • Article
  • Open Access
8 Citations
4,614 Views
15 Pages

Quality of Life in Caregivers of Children and Adolescents with Autistic Spectrum Disorder: Development and Validation of the Questionnaire

  • Claudia B. Pratesi,
  • Alessandra Baeza Garcia,
  • Riccardo Pratesi,
  • Lenora Gandolfi,
  • Mariana Hecht,
  • Eduardo Yoshio Nakano and
  • Renata Puppin Zandonadi

Studies have shown that children and adolescents with autism and their relatives present a high level of stress and more family problems, impacting parents’ and caregivers’ quality of life (QoL). Despite studies on this subject, there is no specific...

  • Review
  • Open Access
22 Citations
4,648 Views
21 Pages

Rat Models of Vocal Deficits in Parkinson’s Disease

  • Maryann N. Krasko,
  • Jesse D. Hoffmeister,
  • Nicole E. Schaen-Heacock,
  • Jacob M. Welsch,
  • Cynthia A. Kelm-Nelson and
  • Michelle R. Ciucci

Parkinson’s disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of li...

  • Article
  • Open Access
14 Citations
4,762 Views
10 Pages

Coping Strategies, Anxiety and Depression in OCD and Schizophrenia: Changes during COVID-19

  • Ángel Rosa-Alcázar,
  • José Luis Parada-Navas,
  • María Dolores García-Hernández,
  • Sergio Martínez-Murillo,
  • Pablo J. Olivares-Olivares and
  • Ana I. Rosa-Alcázar

Background: The main aim was to examine changes in coping strategies, anxiety and depression in obsessive–compulsive and schizophrenia patients during COVID-19, in addition to controlling the influence of intolerance to uncertainty and experiential a...

  • Review
  • Open Access
7 Citations
4,420 Views
15 Pages

Aging-Related Tau Astrogliopathy in Aging and Neurodegeneration

  • Heather McCann,
  • Briony Durand and
  • Claire E. Shepherd

Astrocytes are of vital importance to neuronal function and the health of the central nervous system (CNS), and astrocytic dysfunction as a primary or secondary event may predispose to neurodegeneration. Until recently, the main astrocytic tauopathie...

  • Article
  • Open Access
6 Citations
4,014 Views
20 Pages

Fourier Transform Infrared Imaging—A Novel Approach to Monitor Bio Molecular Changes in Subacute Mild Traumatic Brain Injury

  • Fazle Rakib,
  • Khalid Al-Saad,
  • Sebnem Garip Ustaoglu,
  • Ehsan Ullah,
  • Raghvendra Mall,
  • Richard Thompson,
  • Essam M. Abdelalim,
  • Tariq Ahmed,
  • Feride Severcan and
  • Mohamed H. M. Ali

Traumatic brain injury (TBI) can be defined as a disorder in the function of the brain after a bump, blow, or jolt to the head, or penetrating head injury. Mild traumatic brain injury (mTBI) can cause devastating effects, such as the initiation of lo...

  • Article
  • Open Access
18 Citations
6,270 Views
14 Pages

Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome—An Experimental Study

  • Ijasul M. Haque,
  • Akhilesh Mishra,
  • Bhupinder Singh Kalra and
  • Shalini Chawla

Patients with alcohol use disorder experience alcohol withdrawal syndrome due to the sudden cessation of alcohol. This study was designed to evaluate the protective effect of Ashwagandha and Brahmi on alcohol withdrawal in rats. Thirty rats of either...

  • Systematic Review
  • Open Access
19 Citations
8,556 Views
19 Pages

Individuals with cerebral palsy have difficulties performing activities of daily living. Beyond motor execution impairments, they exhibit motor planning deficits contributing to their difficulties. The objective of this review is to synthesize the be...

  • Article
  • Open Access
11 Citations
4,025 Views
10 Pages

Functional Connectivity-Derived Optimal Gestational-Age Cut Points for Fetal Brain Network Maturity

  • Josepheen De Asis-Cruz,
  • Scott Douglas Barnett,
  • Jung-Hoon Kim and
  • Catherine Limperopoulos

The architecture of the human connectome changes with brain maturation. Pivotal to understanding these changes is defining developmental periods when transitions in network topology occur. Here, using 110 resting-state functional connectivity data se...

  • Article
  • Open Access
7 Citations
4,304 Views
23 Pages

The main goal of this paper is to analyze written texts produced by monolingual French university students, with and without dyslexia. More specifically, we were interested in the linguistic characteristics of the words used during a written producti...

  • Review
  • Open Access
17 Citations
9,107 Views
10 Pages

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder determined by a complex of factors (genetic and environmental). On a pathophysiological basis hyperbaric oxygen therapy (HBOT) has been suggested as an effective therapeutic metho...

  • Article
  • Open Access
12 Citations
4,750 Views
22 Pages

Combined Low Dose of Ketamine and Social Isolation: A Possible Model of Induced Chronic Schizophrenia-Like Symptoms in Male Albino Rats

  • Suzanne Estaphan,
  • Alexandrina-Stefania Curpăn,
  • Dalia Khalifa,
  • Laila Rashed,
  • Andrei Ciobica,
  • Adrian Cantemir,
  • Alin Ciobica,
  • Constantin Trus,
  • Mahmoud Ali and
  • Asmaa ShamsEldeen

While animal models for schizophrenia, ranging from pharmacological models to lesions and genetic models, are available, they usually mimic only the positive symptoms of this disorder. Identifying a feasible model of chronic schizophrenia would be va...

  • Article
  • Open Access
16 Citations
3,600 Views
10 Pages

Characterization of Early Life Stress-Affected Gut Microbiota

  • Noriyoshi Usui,
  • Hideo Matsuzaki and
  • Shoichi Shimada

Early life stress (ELS), such as neglect and maltreatment, exhibits a strong impact on the mental and brain development of children. However, it is not fully understood how ELS affects the body and behavior of children. Therefore, in this study, we p...

  • Perspective
  • Open Access
7 Citations
3,661 Views
5 Pages

In the current paper, we present a view of autism spectrum disorder (ASD) which avoids the typical relational issues, instead drawing on philosophy, in particular Husserlian phenomenology. We begin by following the recent etiological perspectives tha...

  • Article
  • Open Access
2 Citations
3,872 Views
19 Pages

In this study, we examined eye movements and comprehension in sentences containing a relative clause. To date, few studies have focused on syntactic processing in dyslexia and so one goal of the study is to contribute to this gap in the experimental...

  • Review
  • Open Access
10 Citations
3,736 Views
11 Pages

In this paper, utilizing the interactional research paradigm developed by Éva Bányai, we discuss the hypnotic relationship from the viewpoint of interactional synchrony. Based on our three decades of empirical studies of an interactional paradigm, we...

  • Review
  • Open Access
29 Citations
7,133 Views
14 Pages

Nearly 20% of genes located on the X chromosome are associated with neurodevelopmental disorders (NDD) due to their expression and role in brain functioning. Given their location, several of these genes are either subject to or can escape X-chromosom...

  • Article
  • Open Access
19 Citations
7,007 Views
28 Pages

Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk

  • Punnag Saha,
  • Peter T. Skidmore,
  • LaRinda A. Holland,
  • Ayan Mondal,
  • Dipro Bose,
  • Ratanesh K. Seth,
  • Kimberly Sullivan,
  • Patricia A. Janulewicz,
  • Ronnie Horner and
  • Saurabh Chatterjee
  • + 4 authors

Gulf War Illness (GWI) is a chronic multi-symptomatic illness that is associated with fatigue, pain, cognitive deficits, and gastrointestinal disturbances and presents a significant challenge to treat in clinics. Our previous studies show a role of a...

  • Review
  • Open Access
12 Citations
4,284 Views
10 Pages

Amyotrophic lateral sclerosis (ALS) is characterised by progressive dysfunction of the upper and lower motor neurons. The disease can evolve over time from focal limb or bulbar onset to involvement of other regions. There is some clinical heterogenei...

  • Brief Report
  • Open Access
5 Citations
3,909 Views
11 Pages

Imputing the Number of Responders from the Mean and Standard Deviation of CGI-Improvement in Clinical Trials Investigating Medications for Autism Spectrum Disorder

  • Spyridon Siafis,
  • Alessandro Rodolico,
  • Oğulcan Çıray,
  • Declan G. Murphy,
  • Mara Parellada,
  • Celso Arango and
  • Stefan Leucht

Introduction: Response to treatment, according to Clinical Global Impression-Improvement (CGI-I) scale, is an easily interpretable outcome in clinical trials of autism spectrum disorder (ASD). Yet, the CGI-I rating is sometimes reported as a continuo...

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Brain Sci. - ISSN 2076-3425