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Volume 11
Issue 8
10.3390/brainsci11081041
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Article
Peer-Review Record

Structural Connectivity Alterations in Operculo-Insular Epilepsy

Brain Sci. 2021, 11(8), 1041; https://doi.org/10.3390/brainsci11081041
by Sami Obaid 1,2,3,4,*, François Rheault 4, Manon Edde 4, Guido I. Guberman 4,5, Etienne St-Onge 4, Jasmeen Sidhu 4, Alain Bouthillier 3, Alessandro Daducci 6, Jimmy Ghaziri 2, Michel W. Bojanowski 3, Dang K. Nguyen 1,2,7,† and Maxime Descoteaux 4,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Brain Sci. 2021, 11(8), 1041; https://doi.org/10.3390/brainsci11081041
Submission received: 24 June 2021 / Revised: 27 July 2021 / Accepted: 2 August 2021 / Published: 5 August 2021
(This article belongs to the Collection Insula: Rediscovering the Hidden Lobe of the Brain)

Round 1

Reviewer 1 Report

Overall a good neuroimaging work in OIE and epilepsy network, however, there are some points to clarify and some questions/comments...

  • How was the diagnosis established in OIE? One patient of TLE received icEEG in TLE?
    • “In order to confirm the epileptogenic zone, an icEEG recording was performed in eight OIE and one TLE participants”
    • “In all patients of the TLE group, we ascertained the inclusion of patients with a seizure focus within the mesial temporal lobe through non-invasive investigations revealing hippocampal sclerosis and medial temporal lobe epilepsy.
  • What was the temporal association with the MRI, icEEG, surgery? 
  • Was there any association among the connectivity, EEG/icEEG and MEG, if analyzed?
  • Is there any patient excluded from OIE group because of the poor Engle class after surgery? If so it would be interesting to see the connectivity difference within the group and/or also validate the connectivity map of OIE. Any attempt were made to explore the favorable vs non-favorable OIE and validating the connectivity and cross reference to the clinical, imaging and electrophysiological concordance?
  • Authors present epileptic network in OIE with potential description of “signature” network that seems overstatement in absence control/negative control.

Author Response

please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

The authors evaluated the structural connectivity distribution in operculo-insular epilepsy (OIE) using a novel method named  COMMIT (Convex Optimization Modeling for Microstructure Informed Tractography)-weight. The results regarding the distribution of connectivity may represent a potential biomarker in the diagnosis of OIE. 

The study is interesting, well described and the data are clear.

This is a very interesting paper.

Author Response

please see the attachment

Author Response File: Author Response.pdf

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