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Volume 12
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10.3390/brainsci12101296
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Article

Transcutaneous Vagus Nerve Stimulation Could Improve the Effective Rate on the Quality of Sleep in the Treatment of Primary Insomnia: A Randomized Control Trial

by
Yating Wu
1,2,
Lu Song
3,
Xian Wang
1,
Ning Li
1,
Shuqin Zhan
1,
Peijing Rong
4,
Yuping Wang
1 and
Aihua Liu
1,*
1
Neurology Department, Xuanwu Hospital, Capital Medical University, Beijing 100054, China
2
Neurology Department, Beijing Tsinghua Changgung Hospital, Beijing 102218, China
3
Rehabilitation Medicine Center, Fuxing Hospital, Capital Medical University, Beijing 100038, China
4
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
*
Author to whom correspondence should be addressed.
Brain Sci. 2022, 12(10), 1296; https://doi.org/10.3390/brainsci12101296
Submission received: 1 August 2022 / Revised: 23 September 2022 / Accepted: 23 September 2022 / Published: 26 September 2022
(This article belongs to the Section Clinical Neuroscience)
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Abstract

(1) Background: The purpose of this study was to investigate the efficacy and safety of transcutaneous vagus nerve stimulation (t-VNS) in the treatment of primary insomnia. (2) Methods: This is a single center, randomized, double-blind study. A total of 30 patients diagnosed with primary insomnia were randomly divided into two groups to receive 20 Hz t-VNS in either the auricular concha area (treatment group) or periauricular area (control group), twice a day for 20 min during a one-month study period. The effective rate of treatment, defined as a ≥50% reduction of the Pittsburgh Sleep Index Scale (PSQI) after treatment, was compared between the two groups as the primary outcome. Response rate (defined as ≥10% change in the PSQI score), and changes in the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores were also assessed. (3) Results: After one month of treatment, the PSQI score of the treatment group decreased significantly (p = 0.001). The effective rate of the treatment group (73% vs. 27%, p = 0.027) was significantly higher than that of the control group. No statistical differences in changes of HAMA and HAMD scores were detected between the two groups. There were no complications in all patients. (4) Conclusion: T-VNS appeared to be a safe and effective treatment for primary insomnia.
Keywords: transcutaneous vagus nerve stimulation; primary insomnia; Pittsburgh Sleep Index; anxiety; depression transcutaneous vagus nerve stimulation; primary insomnia; Pittsburgh Sleep Index; anxiety; depression

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MDPI and ACS Style

Wu, Y.; Song, L.; Wang, X.; Li, N.; Zhan, S.; Rong, P.; Wang, Y.; Liu, A. Transcutaneous Vagus Nerve Stimulation Could Improve the Effective Rate on the Quality of Sleep in the Treatment of Primary Insomnia: A Randomized Control Trial. Brain Sci. 2022, 12, 1296. https://doi.org/10.3390/brainsci12101296

AMA Style

Wu Y, Song L, Wang X, Li N, Zhan S, Rong P, Wang Y, Liu A. Transcutaneous Vagus Nerve Stimulation Could Improve the Effective Rate on the Quality of Sleep in the Treatment of Primary Insomnia: A Randomized Control Trial. Brain Sciences. 2022; 12(10):1296. https://doi.org/10.3390/brainsci12101296

Chicago/Turabian Style

Wu, Yating, Lu Song, Xian Wang, Ning Li, Shuqin Zhan, Peijing Rong, Yuping Wang, and Aihua Liu. 2022. "Transcutaneous Vagus Nerve Stimulation Could Improve the Effective Rate on the Quality of Sleep in the Treatment of Primary Insomnia: A Randomized Control Trial" Brain Sciences 12, no. 10: 1296. https://doi.org/10.3390/brainsci12101296

APA Style

Wu, Y., Song, L., Wang, X., Li, N., Zhan, S., Rong, P., Wang, Y., & Liu, A. (2022). Transcutaneous Vagus Nerve Stimulation Could Improve the Effective Rate on the Quality of Sleep in the Treatment of Primary Insomnia: A Randomized Control Trial. Brain Sciences, 12(10), 1296. https://doi.org/10.3390/brainsci12101296

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