Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants and Neuropsychological Tests
2.2. Structural MRI Acquisition
2.3. Image Analysis
2.4. Statistical Analysis
3. Results
3.1. Demographic Characteristics and Neuropsychological Functions in Each Group
3.2. Hippocampal Microstructure
3.3. Association between Hippocampal Microstructure and Verbal Memory
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Subclinical Depression (n = 19) | Control (n = 19) | t or u | p | |
---|---|---|---|---|
Age | 72.37 ± 4.60 | 69.58 ± 4.51 | 1.89 | 0.067 |
Sex | Male: 6, Female: 13 | Male: 6, Female: 13 | ||
Years of education | 10.21 ± 4.08 | 10.89 ± 3.93 | −0.63 | 0.628 |
GDS-K | 10.26 ± 2.00 | 2.21 ± 2.27 | 11.60 | <0.001 |
MMSE-KC | 27.89 ± 1.37 | 28.58 ± 0.77 | −1.90 | 0.068 |
Word-List Test (z-score) | ||||
Learning | 0.37 ± 0.70 | 0.73 ± 0.84 | −1.46 | 0.153 |
Recall | −0.45 ± 0.73 | 0.23 ± 0.88 | −2.60 | 0.014 |
Recognition | −0.61 ± 0.83 | 0.48 ± 0.33 | −4.13 | <0.001 |
eTIV (mm3) | 1.52 × 106 ± 1.22 × 105 | 1.52 × 106 ± 1.61 × 105 | −0.05 | 0.964 |
Left Hippocampus | Right Hippocampus | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Subclinical Depression | Control | Fgroup | pgroup | ES | FDR | Subclinical Depression | Control | Fgroup | pgroup | ES | FDR | |
Parasubiculum | 59.44 ± 15.12 | 56.59 ± 13.17 | 0.41 | 0.526 | 0.011 | 0.570 | 51.91 ± 8.75 | 53.02 ± 7.06 | 0.05 | 0.827 | 0.006 | 0.827 |
Presubiculum | 279.25 ± 40.09 | 297.26 ± 36.2 | 1.16 | 0.290 | 0.057 | 0.377 | 261.79 ± 31.84 | 284.42 ± 25.67 | 3.21 | 0.082 | 0.153 | 0.124 |
Subiculum | 388.32 ± 46.81 | 435.28 ± 49.72 | 6.21 | 0.018 | 0.208 | 0.039 | 399.61 ± 55 | 444.59 ± 38.01 | 5.27 | 0.028 | 0.212 | 0.061 |
CA1 | 545.73 ± 62.86 | 614.26 ± 72.41 | 6.41 | 0.016 | 0.227 | 0.039 | 589.8 ± 68.66 | 662.84 ± 74.75 | 6.36 | 0.016 | 0.233 | 0.042 |
CA3 | 179.19 ± 24.03 | 208.56 ± 26.05 | 9.44 | 0.004 | 0.277 | 0.020 | 204.64 ± 26.82 | 226.4 ± 30.16 | 3.12 | 0.086 | 0.144 | 0.124 |
CA4 | 217.84 ± 25.93 | 241.02 ± 22.35 | 5.16 | 0.029 | 0.22 | 0.054 | 229.15 ± 24.38 | 257.3 ± 25.09 | 7.78 | 0.008 | 0.308 | 0.035 |
GC-ML-DG | 248.06 ± 32.73 | 277.14 ± 30.52 | 4.37 | 0.044 | 0.218 | 0.064 | 261.91 ± 30.42 | 295.28 ± 32.66 | 6.35 | 0.016 | 0.279 | 0.042 |
Molecular layer | 475.11 ± 52.46 | 535.01 ± 50.56 | 8.77 | 0.005 | 0.284 | 0.020 | 503.02 ± 59.13 | 564.59 ± 47.84 | 8.08 | 0.007 | 0.293 | 0.035 |
HATA | 49.35 ± 12.17 | 52.72 ± 10.62 | 0.02 | 0.888 | 0.027 | 0.888 | 52.18 ± 9.39 | 55.98 ± 10.04 | 0.08 | 0.779 | 0.051 | 0.827 |
Fimbria | 56.72 ± 24.1 | 67.7 ± 18.85 | 1.02 | 0.321 | 0.069 | 0.379 | 50.75 ± 24.61 | 63.95 ± 17.7 | 1.42 | 0.242 | 0.105 | 0.315 |
Hippocampal tail | 478.7 ± 64.32 | 564.33 ± 55.91 | 15.10 | <0.001 | 0.353 | <0.001 | 526.88 ± 62.62 | 575.37 ± 49.44 | 4.11 | 0.050 | 0.179 | 0.093 |
Hippocampal fissure | 146.91 ± 19.75 | 170.35 ± 35.74 | 4.93 | 0.033 | 0.149 | 0.054 | 166.39 ± 28.5 | 179.03 ± 37.85 | 1.11 | 0.300 | 0.036 | 0.355 |
Whole hippocampus | 2976.78 ± 323.44 | 3350.84 ± 314.1 | 8.52 | 0.006 | 0.310 | 0.020 | 3130.97 ± 343.42 | 3484.41 ± 271.9 | 7.79 | 0.008 | 0.324 | 0.035 |
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Lee, J.; Ju, G.; Park, H.; Chung, S.; Son, J.-W.; Shin, C.-J.; Lee, S.I.; Kim, S. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain Sci. 2022, 12, 329. https://doi.org/10.3390/brainsci12030329
Lee J, Ju G, Park H, Chung S, Son J-W, Shin C-J, Lee SI, Kim S. Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression. Brain Sciences. 2022; 12(3):329. https://doi.org/10.3390/brainsci12030329
Chicago/Turabian StyleLee, Jeonghwan, Gawon Ju, Hyemi Park, Seungwon Chung, Jung-Woo Son, Chul-Jin Shin, Sang Ick Lee, and Siekyeong Kim. 2022. "Hippocampal Subfields and White Matter Connectivity in Patients with Subclinical Geriatric Depression" Brain Sciences 12, no. 3: 329. https://doi.org/10.3390/brainsci12030329