Comparative Analysis of Brain Coping Mechanisms in Small Left-Hemisphere Lesions: Incidental vs. Symptomatic Gliomas
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
Lesion Site | Vol (cm3) | Gender | Age | Edu | Hand | Naming (/30) | Symptomatology | |
---|---|---|---|---|---|---|---|---|
p1 | Frontal | 18 | F | 73 | 5 | 100 | 29 | Speech arrest, R arm myoclonus |
p2 | Frontal | 13 | M | 28 | 13 | 100 | 30 | Epileptic attacks |
p3 | Temporal | 30 | M | 43 | 11 | 100 | 28 | Auditory hallucinations |
p4 | Temporal | 10 | F | 48 | 18 | 100 | 30 | Aphasia, anomia |
p5 | Parietal | 15 | F | 46 | 18 | 100 | 28 | Epileptic attacks, paresthesia (lips) |
p6 | Frontal | 33 | F | 36 | 13 | −50 | 30 | Epileptic attacks, fatigue, olfactory hallucinations |
p7 | Frontal | 16 | M | 45 | 13 | 100 | 30 | Epileptic attacks, production aphasia, paresthesia (R arm) |
p8 | Frontal | 32 | M | 40 | 5 | 100 | 30 | Epileptic attacks, brain fog |
p9 | Frontal | 36 | M | 36 | 8 | 100 | 30 | Anomia, production aphasia |
p10 | Frontal | 22 | M | 49 | 8 | 100 | 29 | Epileptic attacks, phonological dysarthria |
p11 | Frontal | 23 | M | 44 | 13 | 100 | 30 | Epileptic attacks |
p12 | Temporal | 15 | M | 42 | 13 | 96.67 | 30 | Epileptic attacks, anomia, phonological dysarthria |
p13 | Frontal | 27 | F | 35 | 18 | 100 | 28 | Epileptic attacks |
2.2. Imaging Data
2.3. MRI Structural Analysis
2.4. fMRI Data Acquisition
fMRI Naming Task
2.5. Statistical Analyses
2.6. fMRI Data Processing
2.7. DTI Data Acquisition and Analysis
3. Results
3.1. Clinical Data
3.2. Functional Naming Network
3.3. DTI Parameters
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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sLGG | iLGG | Between-Group Difference | |
---|---|---|---|
Sex | 7 F, 6 M | 5 F, 8 M | χ2 = 0.62, df = 1, p = 0.43 (n.s.) |
Age (years) | M = 43.46, SD = 12.54 | M = 37.46, SD = 12.54 | U = 61.50, p = 0.24 (n.s.) |
Education (years) | M = 12.00, SD = 4.51 | M = 13.38, SD = 2.53 | U = 70.00, p = 0.43 (n.s.) |
Handedness 1 | Right-handed = 12 Left-handed = 1 | Right-handed = 12 Left-handed = 1 | - |
Lesion volume | 22.31 cm3 (SD = 8.57 cm3; range = 10–36 cm3; median = 12 cm3) | 18.54 cm3 (SD = 10.71 cm3, range = 8–40 cm3; median = 18 cm3) | U = 57.00, p = 0.16 (n.s.) |
Lesion growth pattern | Expansive for all patients but one (p9, see Table 2) | Expansive for all patients but one (p3 [24]) | - |
Symptoms | Diverse symptoms and, particularly, epileptic seizures, which characterized all the patients in this group. 7 had language-related manifestations. | none | - |
Object-naming abilities (BADA test [26]) | score ≥ 28/30 | score ≥ 28/30 | - |
Cluster | Cluster Size (Voxels) | T | Macroanatomical Area | Cytoarchitectonic Localization | MNI Coordinates | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
iLGG masked exclusively by sLGG | |||||||
1. | 188 | ||||||
4.73 | L precentral gyrus | Area 44 | −48 | 8 | 34 | ||
5.14 | L middle frontal gyrus | - | −50 | 24 | 32 | ||
4.13 | L inferior frontal gyrus | - | −46 | 26 | 24 | ||
2. | 149 | ||||||
6.83 | L superior temporal gyrus | Area PFcm (IPL) | −54 | −38 | 22 | ||
4.95 | L supramarginal gyrus | Area PFcm (IPL) | −56 | −36 | 26 | ||
3. | 150 | ||||||
6.23 | R inferior frontal gyrus | Area 45 | 52 | 28 | 20 | ||
5.43 | R middle frontal gyrus | - | 52 | 26 | 32 | ||
sLGG masked exclusively by iLGG | |||||||
No suprathresholded clusters |
Cluster | Cluster Size (Voxels) | T | Macroanatomical Area | Cytoarchitectonic Localization | MNI Coordinates | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
iLGG masked inclusively by sLGG | |||||||
1. | 7.975 | ||||||
12.85 | R cuneus | Area hOc2 [V2] | 15 | −98 | 10 | ||
11.74 | L superior occipital gyrus | Area hOc3d [V3] | −16 | −96 | 10 | ||
9.73 | L middle occipital gyrus | Area hOc4lp | −30 | −86 | 4 | ||
9.59 | L fusiform gyrus | - | −36 | −58 | −10 | ||
9.58 | R middle occipital gyrus | Area hOc4lp | 38 | −84 | 10 | ||
9.56 | L middle occipital gyrus | Area hOc4d [V3A] | −24 | −88 | 14 | ||
9.31 | R superior occipital gyrus | Area hOc3d [V3d] | 20 | −94 | 20 | ||
8.94 | R fusiform gyrus | Area FG3 | 30 | −60 | −6 | ||
2. | 830 | ||||||
7.62 | L precentral gyrus | - | −48 | −4 | 42 | ||
6.19 | L precentral gyrus | Area 44 | −48 | 8 | 32 | ||
4.98 | L inferior frontal gyrus | Area 45 | −52 | 26 | 24 | ||
4.81 | L inferior frontal gyrus | Area 44 | −52 | 12 | 26 | ||
3. | 686 | ||||||
8.12 | R posterior-medial frontal gyrus | - | 2 | 14 | 56 | ||
7.05 | L posterior-medial frontal gyrus | - | −4 | 0 | 64 | ||
4. | 646 | ||||||
7.77 | R precentral gyrus | - | 52 | −2 | 48 | ||
6.06 | R inferior frontal gyrus | - | 40 | 6 | 30 | ||
5.87 | R middle frontal gyrus | - | 46 | −2 | 54 | ||
5. | 406 | ||||||
6.14 | L thalamus | Thalamus: Visual | −24 | −28 | −4 | ||
5.71 | L hippocampus | - | −28 | −28 | −8 | ||
6. | 317 | ||||||
6.60 | R inferior frontal gyrus | Area 45 | 48 | 20 | 6 | ||
6.39 | R insula | - | 32 | 28 | 4 | ||
4.93 | R inferior frontal gyrus | Area 44 | 52 | 14 | 2 | ||
7. | 254 | ||||||
6.73 | N/A | - | 26 | −32 | 8 | ||
6.70 | R hippocampus | - | 24 | −24 | −10 | ||
8. | 95 | 6.45 | N/A | Thalamus: Temporal | 24 | −28 | −2 |
6.89 | L inferior frontal gyrus | - | −34 | 32 | 0 |
Cluster | Cluster Size (Voxels) | T | Macroanatomical Area | Cytoarchitectonic Localization | MNI Coordinates | ||
---|---|---|---|---|---|---|---|
x | y | z | |||||
sLGG masked inclusively by iLGG | |||||||
1. | 8149 | ||||||
11.31 | R cuneus | Area hOc2 [V2] | 16 | −98 | 12 | ||
10.12 | N/A | Area FG3 | −35 | −55 | −8 | ||
10.07 | L middle occipital gyrus | Area hOc4d | −24 | −88 | 14 | ||
8.47 | L middle occipital gyrus | Area hOc3d [V3] | −18 | −96 | 10 | ||
8.46 | L inferior temporal gyrus | - | −44 | −62 | −6 | ||
8.20 | L inferior occipital gyrus | Area hOc4la | −46 | −70 | −4 | ||
7.46 | R angular gyrus | Area hIP3 (IPS) | 28 | −56 | 46 | ||
7.36 | R middle occipital gyrus | Area hOc4la | 38 | −80 | 8 | ||
2. | 354 | ||||||
6.29 | R precentral gyrus | - | 44 | 8 | 32 | ||
4.61 | R inferior frontal gyrus | Area 45 | 54 | 20 | 25 | ||
4.18 | R middle frontal gyrus | - | 44 | −2 | 54 | ||
3. | 310 | ||||||
5.88 | L inferior frontal gyrus | - | −52 | 36 | 0 | ||
5.64 | L insula | - | −30 | 28 | −2 | ||
4.44 | L inferior frontal gyrus | Area 44 | −52 | 12 | 4 | ||
4. | 283 | ||||||
6.65 | N/A | - | 26 | −30 | 8 | ||
6.24 | L thalamus | Thalamus: Temporal | 24 | −28 | −2 | ||
5. | 265 | ||||||
5.70 | L posterior-medial frontal gyrus | - | −4 | 0 | 64 | ||
5.50 | R posterior-medial frontal gyrus | - | 8 | 12 | 48 | ||
6. | 261 | L inferior frontal gyrus | Area 44 | −44 | 10 | 24 | |
L inferior frontal gyrus | Area 45 | −54 | 28 | 16 | |||
7. | 238 | ||||||
6.89 | L thalamus | Thalamus: Temporal | −18 | −32 | 2 | ||
8. | 228 | 6.41 | L thalamus | Thalamus: Visual | −26 | −25 | 4 |
6.25 | R insula | - | 34 | 20 | 6 | ||
5.41 | R inferior frontal gyrus | - | 40 | 24 | 6 | ||
4.31 | R inferior frontal gyrus | Area 45 | 52 | 22 | 2 | ||
9. | 222 | ||||||
5.68 | L precentral gyrus | - | −50 | 0 | 46 |
ILF | IFOF | UF | Whole AF | Long AF | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LH | RH | LH | RH | LH | RH | LH | RH | LH | RH | |||||||||||
Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | Num | FA | |
iLGG | 277.37 (191.59) | 0.47 (0.03) | 244.72 (140.78) | 0.45 (0.02) | 173.55 (96.76) | 0.49 (0.03) | 308.36 (191.45) | 0.49 (0.02) | 227.55 (122.39) | 0.42 (0.03) | 238.28 (127.73) | 0.42 (0.01) | 555.63 (273.21) | 0.45 (0.03) | 598.82 (144.54) | 0.46 (0.03) | 198.18 (131.97) | 0.47 (0.04) | 132.36 (112.63) | 0.46 (0.04) |
sLGG | 228.60 (134.45) | 0.46 (0.04) | 235.80 (125.25) | 0.46 (0.03) | 155.30 (117.18) | 0.47 (0.05) | 237.00 (88.39) | 0.49 (0.03) | 175.801 (47.64) | 0.40 (0.03) | 159.60 (81.86) | 0.41 (0.03) | 435.50 (252.15) | 0.44 (0.04) | 588.90 (208.55) | 0.44 (0.03) | 163.50 (137.90) | 0.47 (0.03) | 115.20 (103.53) | 0.45 (0.03) |
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Cargnelutti, E.; Ius, T.; Maieron, M.; D’Agostini, S.; Skrap, M.; Tomasino, B. Comparative Analysis of Brain Coping Mechanisms in Small Left-Hemisphere Lesions: Incidental vs. Symptomatic Gliomas. Brain Sci. 2024, 14, 887. https://doi.org/10.3390/brainsci14090887
Cargnelutti E, Ius T, Maieron M, D’Agostini S, Skrap M, Tomasino B. Comparative Analysis of Brain Coping Mechanisms in Small Left-Hemisphere Lesions: Incidental vs. Symptomatic Gliomas. Brain Sciences. 2024; 14(9):887. https://doi.org/10.3390/brainsci14090887
Chicago/Turabian StyleCargnelutti, Elisa, Tamara Ius, Marta Maieron, Serena D’Agostini, Miran Skrap, and Barbara Tomasino. 2024. "Comparative Analysis of Brain Coping Mechanisms in Small Left-Hemisphere Lesions: Incidental vs. Symptomatic Gliomas" Brain Sciences 14, no. 9: 887. https://doi.org/10.3390/brainsci14090887