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Antioxidants
Volume 10
Issue 12
10.3390/antiox10121867
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Article

Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model

by
Xie Peng
1,†,
Xuelin Cai
1,†,
Jian Li
1,†,
Yingyan Huang
1,
Hao Liu
1,
Jiaqi He
1,
Zhengfeng Fang
1,
Bin Feng
1,
Jiayong Tang
1,
Yan Lin
1,
Xuemei Jiang
1,
Liang Hu
2,
Shengyu Xu
1,
Yong Zhuo
1,
Lianqiang Che
1 and
De Wu
1,*
1
Key Laboratory for Animal Disease Resistant Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China
2
College of Food Science, Sichuan Agricultural University, Ya’an 625014, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2021, 10(12), 1867; https://doi.org/10.3390/antiox10121867
Submission received: 8 September 2021 / Revised: 9 November 2021 / Accepted: 18 November 2021 / Published: 24 November 2021
(This article belongs to the Special Issue Antioxidants in Animal Feed)
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Abstract

Melatonin (MT) is a bio-antioxidant that has been widely used to prevent pregnancy complications, such as pre-eclampsia and IUGR during gestation. This experiment evaluated the impacts of dietary MT supplementation during pregnancy on reproductive performance, maternal–placental–fetal redox status, placental inflammatory response, and mitochondrial function, and sought a possible underlying mechanism in the placenta. Sixteen fifth parity sows were divided into two groups and fed each day of the gestation period either a control diet or a diet that was the same but for 36 mg of MT. The results showed that dietary supplementation with MT increased placental weight, while the percentage of piglets born with weight < 900 g decreased. Meanwhile, serum and placental MT levels, maternal–placental–fetal redox status, and placental inflammatory response were increased by MT. In addition, dietary MT markedly increased the mRNA levels of nutrient transporters and antioxidant-related genes involved in the Nrf2/ARE pathway in the placenta. Furthermore, dietary MT significantly increased ATP and NAD+ levels, relative mtDNA content, and the protein expression of Sirt1 in the placenta. These results suggested that MT supplementation during gestation could improve maternal–placental–fetal redox status and reproductive performance by ameliorating placental antioxidant status, inflammatory response, and mitochondrial dysfunction.
Keywords: melatonin; oxidative stress; placenta; mitochondria; fetal growth; sow melatonin; oxidative stress; placenta; mitochondria; fetal growth; sow

Share and Cite

MDPI and ACS Style

Peng, X.; Cai, X.; Li, J.; Huang, Y.; Liu, H.; He, J.; Fang, Z.; Feng, B.; Tang, J.; Lin, Y.; et al. Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model. Antioxidants 2021, 10, 1867. https://doi.org/10.3390/antiox10121867

AMA Style

Peng X, Cai X, Li J, Huang Y, Liu H, He J, Fang Z, Feng B, Tang J, Lin Y, et al. Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model. Antioxidants. 2021; 10(12):1867. https://doi.org/10.3390/antiox10121867

Chicago/Turabian Style

Peng, Xie, Xuelin Cai, Jian Li, Yingyan Huang, Hao Liu, Jiaqi He, Zhengfeng Fang, Bin Feng, Jiayong Tang, Yan Lin, and et al. 2021. "Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model" Antioxidants 10, no. 12: 1867. https://doi.org/10.3390/antiox10121867

APA Style

Peng, X., Cai, X., Li, J., Huang, Y., Liu, H., He, J., Fang, Z., Feng, B., Tang, J., Lin, Y., Jiang, X., Hu, L., Xu, S., Zhuo, Y., Che, L., & Wu, D. (2021). Effects of Melatonin Supplementation during Pregnancy on Reproductive Performance, Maternal–Placental–Fetal Redox Status, and Placental Mitochondrial Function in a Sow Model. Antioxidants, 10(12), 1867. https://doi.org/10.3390/antiox10121867

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