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Antioxidants
Volume 10
Issue 9
10.3390/antiox10091490
Review Report
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Systematic Review
Peer-Review Record

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-Analysis and Meta-Regression

Antioxidants 2021, 10(9), 1490; https://doi.org/10.3390/antiox10091490
by Elke van Westering-Kroon 1, Maurice J Huizing 1, Eduardo Villamor-Martínez 1,2 and Eduardo Villamor 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Antioxidants 2021, 10(9), 1490; https://doi.org/10.3390/antiox10091490
Submission received: 30 August 2021 / Accepted: 14 September 2021 / Published: 18 September 2021
(This article belongs to the Special Issue Metabolomics, Oxidative, and Nitrosative Stress in the Perinatal Period)

Round 1

Reviewer 1 Report

The article by van Westering-Kroon et al. is well written and all relative data are in the Supporting information. It is professionally at a high level. The text is clear and I have not encountered any inconsistencies. Figures and tables are very well presented and legible. The citations are relevant and homogeneous. In my opinion, the article is perfectly processed and I recommend publishing in its current form.

Reviewer 2 Report

The manuscript submitted for evaluation is a systematic review with the use of meta-analysis and meta-regression. Appropriate statistical methods were used and interesting results were obtained. As a neonatologist, I read this 
work with interest. According to common knowledge among neonatologists
male premature newborns have a worse prognosis when it comes 
to morbidity and mortality than prematurely born girls. The authors of the study decided to check it and obtained confirmation of this known opinion. In the discussion, the authors presented the current  state of knowledge and the scope of research allowing to explain this phenomenon of male disadvantage.
I propose to accept the manuscript for publishing without corrections.

Reviewer 3 Report

The study of van Westering-Kroon and coworkers is a systematic review and meta-analysis on male-female  differences in short-term outcomes of prematurity.  Results revealed a higher clinical instability in preterm boys compared to girls, thus leading to an increased risk of mortality and short- term complications. The subject matter is of interest and paper well written. Hypothesis is clearly presented and it is supported by text, procedures are clear, concise, and easily replicable; the results are logically presented and answer to research hypothesis, statements and conclusions are clearly supported by data and are linked to goals. Study’s implications and limitations are completely and succinctly presented.

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