Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking
Abstract
:1. Introduction
2. Materials and Methods
2.1. Plant Material and Extraction
2.2. Chemicals and Reagents
2.3. Animals
2.4. Preparation of Test Sample Topical Gel
2.5. In Vivo Wound Healing
2.6. Histological Analysis
2.7. Gene Expression Data Analysis
2.8. In Vitro Antioxidant Activity
2.9. Statistical Analysis
2.10. LC-HRMS Metabolomic Analysis
2.11. Molecular Docking
3. Results
3.1. Wound Contraction
3.2. Histological Study
3.3. Gene Expression Data Analysis
3.4. In Vitro Antioxidant Activity
3.5. LC-HRMS Metabolomic Analysis
3.6. Molecular Docking Study
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Ahmed, S.R.; Mostafa, E.M.; Musa, A.; Rateb, E.E.; Al-Sanea, M.M.; Abu-Baih, D.H.; Elrehany, M.A.; Saber, E.A.; Rateb, M.E.; Abdelmohsen, U.R. Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking. Antioxidants 2022, 11, 2258. https://doi.org/10.3390/antiox11112258
Ahmed SR, Mostafa EM, Musa A, Rateb EE, Al-Sanea MM, Abu-Baih DH, Elrehany MA, Saber EA, Rateb ME, Abdelmohsen UR. Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking. Antioxidants. 2022; 11(11):2258. https://doi.org/10.3390/antiox11112258
Chicago/Turabian StyleAhmed, Shaimaa R., Ehab M. Mostafa, Arafa Musa, Enas Ezzat Rateb, Mohammad M. Al-Sanea, Dalia H. Abu-Baih, Mahmoud A. Elrehany, Entesar Ali Saber, Mostafa E. Rateb, and Usama Ramadan Abdelmohsen. 2022. "Wound Healing and Antioxidant Properties of Launaea procumbens Supported by Metabolomic Profiling and Molecular Docking" Antioxidants 11, no. 11: 2258. https://doi.org/10.3390/antiox11112258