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Antioxidants
Volume 12
Issue 4
10.3390/antiox12040787
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Review

Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review

by
Nur Izzah Md Fadilah
1,
Shou Jin Phang
2,
Nurkhuzaiah Kamaruzaman
3,
Atiqah Salleh
1,
Mazlan Zawani
1,
Arka Sanyal
4,
Manira Maarof
1 and
Mh Busra Fauzi
1,*
1
Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia
2
Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia
3
Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Malaysia
4
Department of Biotechnology, KIIT University, Bhubaneswar 751024, India
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(4), 787; https://doi.org/10.3390/antiox12040787
Submission received: 17 December 2022 / Revised: 21 February 2023 / Accepted: 7 March 2023 / Published: 23 March 2023
(This article belongs to the Special Issue Oxidative Stress in Wound Healing)
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Abstract

Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarises the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years.
Keywords: antioxidant; biomaterials; wound healing; oxidative stress; delivery system antioxidant; biomaterials; wound healing; oxidative stress; delivery system

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MDPI and ACS Style

Fadilah, N.I.M.; Phang, S.J.; Kamaruzaman, N.; Salleh, A.; Zawani, M.; Sanyal, A.; Maarof, M.; Fauzi, M.B. Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review. Antioxidants 2023, 12, 787. https://doi.org/10.3390/antiox12040787

AMA Style

Fadilah NIM, Phang SJ, Kamaruzaman N, Salleh A, Zawani M, Sanyal A, Maarof M, Fauzi MB. Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review. Antioxidants. 2023; 12(4):787. https://doi.org/10.3390/antiox12040787

Chicago/Turabian Style

Fadilah, Nur Izzah Md, Shou Jin Phang, Nurkhuzaiah Kamaruzaman, Atiqah Salleh, Mazlan Zawani, Arka Sanyal, Manira Maarof, and Mh Busra Fauzi. 2023. "Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review" Antioxidants 12, no. 4: 787. https://doi.org/10.3390/antiox12040787

APA Style

Fadilah, N. I. M., Phang, S. J., Kamaruzaman, N., Salleh, A., Zawani, M., Sanyal, A., Maarof, M., & Fauzi, M. B. (2023). Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review. Antioxidants, 12(4), 787. https://doi.org/10.3390/antiox12040787

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