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Article

Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia

1
Institute of Neurobiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 23, 1113 Sofia, Bulgaria
2
Department of Healthcare, South-West University “Neofit Rilski”, Ivan Mihailov Str. 66, 2700 Blagoevgrad, Bulgaria
3
Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. 21, 1113 Sofia, Bulgaria
4
National Sports Academy, Department of Physiology and Biochemistry, Acad. S. Mladenov Str. 21, 1700 Sofia, Bulgaria
5
Institute of Cryobiology and Food Technologies, Cherni Vrah Blvd 53, 1407 Sofia, Bulgaria
6
National Center of Infectious and Parasitic Diseases, Yanko Sakazov Blvd 26, 1504 Sofia, Bulgaria
7
Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria
*
Authors to whom correspondence should be addressed.
Antioxidants 2023, 12(12), 2050; https://doi.org/10.3390/antiox12122050
Submission received: 1 November 2023 / Revised: 21 November 2023 / Accepted: 23 November 2023 / Published: 28 November 2023

Abstract

Alzheimer’s disease manifests as a complex pathological condition, with neuroinflammation, oxidative stress and cholinergic dysfunction being a few of the many pathological changes. Due to the complexity of the disease, current therapeutic strategies aim at a multitargeted approach, often relying on a combination of substances with versatile and complementary effects. In the present study, a unique combination of α-lipoic acid, citicoline, extracts of leaves from olive tree and green tea, vitamin D3, selenium and an immune-supporting complex was tested in scopolamine-induced dementia in rats. Using behavioral and biochemical methods, we assessed the effects of the combination on learning and memory, and elucidated the mechanisms of these effects. Our results showed that, compared to its components, the experimental combination was most efficient in improving short- and long-term memory as assessed by the step-through method as well as spatial memory as assessed by T-maze and Barnes maze underlined by decreases in AChE activity (p < 0.05) and LPO (p < 0.001), increases in SOD activity in the cortex (p < 0.05) and increases in catalase (p < 0.05) and GPx (p < 0.01) activities and BDNF (p < 0.001) and pCREB (p < 0.05) levels in the hippocampus. No significant histopathological changes or blood parameter changes were detected, making the experimental combination an effective and safe candidate in a multitargeted treatment of AD.
Keywords: Alzheimer’s disease; α-lipoic acid; citicoline; extract of leaves green tea; extract of leaves olive tree; vitamin D3; selenium; scopolamine Alzheimer’s disease; α-lipoic acid; citicoline; extract of leaves green tea; extract of leaves olive tree; vitamin D3; selenium; scopolamine

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MDPI and ACS Style

Tancheva, L.; Kalfin, R.; Minchev, B.; Uzunova, D.; Tasheva, K.; Tsvetanova, E.; Georgieva, A.; Alexandrova, A.; Stefanova, M.; Solak, A.; et al. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants 2023, 12, 2050. https://doi.org/10.3390/antiox12122050

AMA Style

Tancheva L, Kalfin R, Minchev B, Uzunova D, Tasheva K, Tsvetanova E, Georgieva A, Alexandrova A, Stefanova M, Solak A, et al. Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants. 2023; 12(12):2050. https://doi.org/10.3390/antiox12122050

Chicago/Turabian Style

Tancheva, Lyubka, Reni Kalfin, Borislav Minchev, Diamara Uzunova, Krasimira Tasheva, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Ayten Solak, and et al. 2023. "Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia" Antioxidants 12, no. 12: 2050. https://doi.org/10.3390/antiox12122050

APA Style

Tancheva, L., Kalfin, R., Minchev, B., Uzunova, D., Tasheva, K., Tsvetanova, E., Georgieva, A., Alexandrova, A., Stefanova, M., Solak, A., Lazarova, M., Hodzhev, Y., Grigorova, V., Yarkov, D., & Petkova-Kirova, P. (2023). Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Antioxidants, 12(12), 2050. https://doi.org/10.3390/antiox12122050

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