Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study
Abstract
:1. Introduction
2. Methodology
2.1. Study Population
2.2. Traffic Density
2.3. Plasma Metabolite Levels
2.4. Oxidative Stress Biomarkers
2.5. Other Relevant Variables
2.6. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Traffic Density at Home Address (Cars per Day) | ||||
---|---|---|---|---|
Overall | Low Traffic Density | Moderate Traffic Density | High Traffic Density | |
Age, years; mean | 52.74 | 51.90 | 51.66 | 54.59 |
Women; % | 49.78 | 49.21 | 46.23 | 53.72 |
BMI, kg/m2; mean | 26.36 | 26.67 | 26.06 | 26.36 |
Smoking status | ||||
Never; % | 47.23 | 47.40 | 44.15 | 49.75 |
Former; % | 29.53 | 28.39 | 32.71 | 28.50 |
Current; % | 23.22 | 24.19 | 22.34 | 21.75 |
Cumulative smoking, pack-year; mean | 9.08 | 8.05 | 9.59 | 9.59 |
Urine cotinine, mg/dL | ||||
<12 mg/dL | 77.3 | 95.52 | 77.95 | 78.40 |
12–500 mg/dL | 4.73 | 6.05 | 5.1 | 3.08 |
>500 mg/dL | 17.97 | 18.42 | 16.93 | 18.51 |
Alcohol intake status | ||||
Never; % | 39.26 | 44.73 | 32.79 | 40.10 |
Former; % | 8.41 | 8.42 | 8.06 | 8.74 |
Current; % | 52.32 | 46.84 | 56.55 | 51.15 |
eGFR, mL/min/1.73 m2 | 90.84 | 91.7 | 92.13 | 88.77 |
High education; % | 72.92 | 69.21 | 78.19 | 72.00 |
Physical activity, METs min/week; mean | 3135.94 | 3110.10 | 3050.08 | 3242.95 |
Group | Metabolite | MD (95% CI) | p-Value |
---|---|---|---|
Lipoprotein profile | Cholesterol, mg/dL | 1.430 (−2.340, 5.201) | 0.457 |
VLDL cholesterol, mg/dL | 0.638 (−0.130, 1.407) | 0.104 | |
LDL cholesterol, mg/dL | 1.833 (−2.232, 5.898) | 0.377 | |
HDL cholesterol, mg/dL | −0.832 (−2.664, 1.001) | 0.374 | |
IDL cholesterol, mg/dL | 0.487 (−0.067, 1.042) | 0.085 | |
Total VLDL, nmol/L | 0.796 (−1.492, 3.083) | 0.496 | |
Large VLDL, nmol/L | −0.015 (−0.084, 0.054) | 0.496 | |
Medium VLDL, nmol/L | 0.002 (−0.459, 0.463) | 0.994 | |
Small VLDL, nmol/L | 0.808 (−1.252, 2.869) | 0.442 | |
Total LDL, nmol/L | 17.08 (−22.022, 56.182) | 0.392 | |
Large LDL, nmol/L | 2.497 (−3.041, 8.035) | 0.377 | |
Medium LDL, nmol/L | 11.853 (−6.439, 30.146) | 0.204 | |
Small LDL, nmol/L | 2.830 (−17.158, 22.819) | 0.781 | |
Total HDL, nmol/L | −0.311 (−1.207, 0.524) | 0.440 | |
Large HDL, µmol/L | 0.002 (−0.006, 0.010) | 0.695 | |
Medium HDL, µmol/L | 0.004 (−0.301, 0.309) | 0.979 | |
Small HDL, µmol/L | −0.347 (−0.966, 0.271) | 0.271 | |
Amino acids | Alanine | 0.013 (−0.058, 0.084) | 0.718 |
Creatine phosphate | −0.008 (−0.021, 0.004) | 0.187 | |
Creatine | −0.010 (−0.021, 0.002) | 0.090 | |
Cysteine | −0.010 (−0.020, −0.001) | 0.038 | |
Glutamine | −0.008 (−0.063, 0.047) | 0.772 | |
Proline | 0.017 (−0.044, 0.078) | 0.595 | |
Tryptophan | 0.017 (−0.026, 0.060) | 0.432 | |
Tyrosine | −0.014 (−0.036, 0.007) | 0.198 | |
Isoleucine | 0.004 (−0.042, 0.049) | 0.875 | |
Leucine | −0.002 (−0.040, 0.036) | 0.909 | |
Valine | −0.038 (−0.083, 0.006) | 0.093 | |
Inflamation marker | N-acetylglutamine | −0.031 (−0.068, 0.007) | 0.109 |
Fatty acids | CH2CH2CO | 0.155 (0.033, 0.276) | 0.013 |
CH2CH3 | 0.121 (−0.033, 0.274) | 0.123 | |
CH2N | 1.744 (0.277, 3.211) | 0.020 | |
CH3 | 0.063 (−0.358, 0.483) | 0.770 | |
CHCH2CH | 0.005 (−0.095, 0.105) | 0.919 | |
Isobutyrate | −0.042 (−0.077, −0.007) | 0.020 | |
Products of bacterial co-metabolism | Ethanol | −0.004 (−0.196, 0.187) | 0.964 |
Isopropanol | −0.041 (−0.087, 0.006) | 0.087 | |
Methanol | −0.012 (−0.024, 0.001) | 0.065 | |
Trimethylamines | −0.065 (−0.113, −0.018) | 0.008 | |
Phenylpropionate | 0.030 (−0.039, 0.098) | 0.395 | |
O-phosphoethanolamine | −0.036 (−0.079, 0.008) | 0.111 | |
Energy metabolism | Glycolisis | ||
Citrate | −0.024 (−0.060, 0.013) | 0.208 | |
Lactate | 0.299 (−0.065, 0.663) | 0.108 | |
Pyruvate | 0.001 (−0.013, 0.014) | 0.905 | |
Ketone bodies | |||
Acetate | −0.030 (−0.058, −0.002) | 0.034 | |
Acetone | 0.062 (−0.002, 0.127) | 0.057 | |
3-Hydroxybutyrate | −0.006 (−0.063, 0.050) | 0.822 | |
Fluid balance | Albumin | −0.073 (−0.135, −0.011) | 0.022 |
Creatinine | −0.006 (−0.027, 0.015) | 0.572 | |
Oxidative stress markers | GSSG/GSH,% | 3.142 (0.049, 6.236) | 0.047 |
Malondialdehyde (MDA), nmol/mmol creatinine | −0.097 (−0.170, −0.023) | 0.010 | |
8-oxo-7,8-dihydroguanine (8-oxo-dG), nmol/mmol creatinine | 0.116 (−0.068, 0.300) | 0.216 |
KEGG-Based Pathways | Total | Expected | Hits | Enrich. | Raw | Holm | FDR | Metabolites |
---|---|---|---|---|---|---|---|---|
Ratio | p-Value | p-Value | p-Value | |||||
Pantothenate and CoA biosynthesis | 19 | 0.050 | 2 | 40.404 | 0.001 | 0.072 | 0.072 | Cysteine, Valine |
Glycine, serine and threonine metabolism | 33 | 0.086 | 2 | 23.283 | 0.003 | 0.217 | 0.110 | Creatine, Cysteine |
Aminoacyl-tRNA biosynthesis | 48 | 0.125 | 2 | 16.000 | 0.006 | 0.452 | 0.154 | Cysteine, Valine |
Thiamine metabolism | 7 | 0.018 | 1 | 54.945 | 0.018 | 1 | 0.290 | Cysteine |
Valine, leucine and isoleucine biosynthesis | 8 | 0.021 | 1 | 48.077 | 0.021 | 1 | 0.290 | Valine |
Taurine and hypotaurine metabolism | 8 | 0.021 | 1 | 48.077 | 0.021 | 1 | 0.290 | Cysteine |
Pyruvate metabolism | 22 | 0.057 | 1 | 17.452 | 0.056 | 1 | 0.636 | Acetate |
Glycolysis/gluconeogenesis | 26 | 0.068 | 1 | 14.771 | 0.066 | 1 | 0.636 | Acetate |
Glutathione metabolism | 28 | 0.073 | 1 | 13.717 | 0.071 | 1 | 0.636 | Cysteine |
Glyoxylate and dicarboxylate metabolism | 32 | 0.083 | 1 | 12.005 | 0.081 | 1 | 0.636 | Acetate |
Cysteine and methionine metabolism | 33 | 0.086 | 1 | 11.641 | 0.083 | 1 | 0.636 | Cysteine |
Arginine and proline metabolism | 38 | 0.099 | 1 | 10.101 | 0.095 | 1 | 0.648 | Creatine |
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Sanchez-Rodriguez, L.; Galvez-Fernandez, M.; Rojas-Benedicto, A.; Domingo-Relloso, A.; Amigo, N.; Redon, J.; Monleon, D.; Saez, G.; Tellez-Plaza, M.; Martin-Escudero, J.C.; et al. Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study. Antioxidants 2023, 12, 2122. https://doi.org/10.3390/antiox12122122
Sanchez-Rodriguez L, Galvez-Fernandez M, Rojas-Benedicto A, Domingo-Relloso A, Amigo N, Redon J, Monleon D, Saez G, Tellez-Plaza M, Martin-Escudero JC, et al. Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study. Antioxidants. 2023; 12(12):2122. https://doi.org/10.3390/antiox12122122
Chicago/Turabian StyleSanchez-Rodriguez, Laura, Marta Galvez-Fernandez, Ayelén Rojas-Benedicto, Arce Domingo-Relloso, Nuria Amigo, Josep Redon, Daniel Monleon, Guillermo Saez, Maria Tellez-Plaza, Juan Carlos Martin-Escudero, and et al. 2023. "Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study" Antioxidants 12, no. 12: 2122. https://doi.org/10.3390/antiox12122122