Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives

Mauriello, Alfredo; Ascrizzi, Antonia; Roma, Anna Selvaggia; Molinari, Riccardo; Caturano, Alfredo; Imbalzano, Egidio; D’Andrea, Antonello; Russo, Vincenzo

doi:10.3390/antiox13070806

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Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives

by

Alfredo Mauriello

^1,2

,

Antonia Ascrizzi

¹,

Anna Selvaggia Roma

¹,

Riccardo Molinari

¹,

Alfredo Caturano

³

,

Egidio Imbalzano

⁴,

Antonello D’Andrea

²

and

Vincenzo Russo

^1,*

¹

Cardiology Unit, Department of Medical and Translational Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, Italy

²

Cardiology and Intensive Care Unit, Department of Cardiology, Umberto I Hospital, 84014 Nocera Inferiore, Italy

³

Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy

⁴

Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80131 Naples, Italy

^*

Author to whom correspondence should be addressed.

Antioxidants 2024, 13(7), 806; https://doi.org/10.3390/antiox13070806

Submission received: 28 May 2024 / Revised: 21 June 2024 / Accepted: 2 July 2024 / Published: 2 July 2024

(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Diseases (CVDs))

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Abstract

Heart failure (HF) and atrial fibrillation (AF) are prevalent cardiovascular diseases that contribute significantly to morbidity, mortality, hospitalisation, and healthcare costs. It is not uncommon for these conditions to coexist and have mutually reinforcing effects. A critical factor in the aetiology of these conditions is oxidative stress, driven by reactive oxygen species (ROS), which contributes to atrial remodelling and fibrosis. The recent introduction of new drugs for the treatment of heart failure has also had an impact on the management of atrial fibrillation due to their influence on oxidative stress. The objective of this review is to analyse the effects of these therapies, including their role in mitigating ROS, on the prevention and treatment of AF in HF patients.

Keywords: atrial fibrillation; heart failure; empagliflozin; dapagliflozin; vericiguat; sacubitril/valsartan

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MDPI and ACS Style

Mauriello, A.; Ascrizzi, A.; Roma, A.S.; Molinari, R.; Caturano, A.; Imbalzano, E.; D’Andrea, A.; Russo, V. Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives. Antioxidants 2024, 13, 806. https://doi.org/10.3390/antiox13070806

AMA Style

Mauriello A, Ascrizzi A, Roma AS, Molinari R, Caturano A, Imbalzano E, D’Andrea A, Russo V. Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives. Antioxidants. 2024; 13(7):806. https://doi.org/10.3390/antiox13070806

Chicago/Turabian Style

Mauriello, Alfredo, Antonia Ascrizzi, Anna Selvaggia Roma, Riccardo Molinari, Alfredo Caturano, Egidio Imbalzano, Antonello D’Andrea, and Vincenzo Russo. 2024. "Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives" Antioxidants 13, no. 7: 806. https://doi.org/10.3390/antiox13070806

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Effects of Heart Failure Therapies on Atrial Fibrillation: Biological and Clinical Perspectives

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