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Article

Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities

by
Alejandra Bermúdez-Oria
*,
María Luisa Castejón
,
Fátima Rubio-Senent
,
Guillermo Rodríguez-Gutiérrez
and
Juan Fernández-Bolaños
*
Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Pablo de Olavide University Campus, Building 46, Ctra. de Utrera km. 1 41013 Seville, Spain
*
Authors to whom correspondence should be addressed.
Antioxidants 2024, 13(9), 1066; https://doi.org/10.3390/antiox13091066 (registering DOI)
Submission received: 23 July 2024 / Revised: 27 August 2024 / Accepted: 28 August 2024 / Published: 30 August 2024

Abstract

This research explores the health-promoting properties of the pectin–polyphenol complex extracted from alperujo, a by-product of olive oil production. This study investigates the chemical composition and antioxidant activity of the extracts, revealing their high antioxidant activity in vitro. Cell viability assays conducted on colon carcinoma cells (Caco-2) demonstrate the inhibitory effect of the extracts on cell proliferation. However, the extracts do not affect the viability of differentiated Caco-2 cells, suggesting a selective antiproliferative action. Additionally, the extracts reduce intracellular reactive oxygen species (ROS) and nitrite (NO) production in LPS-stimulated murine peritoneal macrophages. Furthermore, the extracts exhibit anti-inflammatory effects by downregulating the secretion of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in these macrophages. These findings highlight the potential of pectin–polyphenol complexes as functional ingredients with significant health benefits, demonstrating antioxidant, antiproliferative, and anti-inflammatory properties.
Keywords: olive oil by-products; alperujo; pectin–polyphenol complex; antioxidant activity; antiproliferative effects; inflammation; cytokines; macrophages olive oil by-products; alperujo; pectin–polyphenol complex; antioxidant activity; antiproliferative effects; inflammation; cytokines; macrophages

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MDPI and ACS Style

Bermúdez-Oria, A.; Castejón, M.L.; Rubio-Senent, F.; Rodríguez-Gutiérrez, G.; Fernández-Bolaños, J. Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities. Antioxidants 2024, 13, 1066. https://doi.org/10.3390/antiox13091066

AMA Style

Bermúdez-Oria A, Castejón ML, Rubio-Senent F, Rodríguez-Gutiérrez G, Fernández-Bolaños J. Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities. Antioxidants. 2024; 13(9):1066. https://doi.org/10.3390/antiox13091066

Chicago/Turabian Style

Bermúdez-Oria, Alejandra, María Luisa Castejón, Fátima Rubio-Senent, Guillermo Rodríguez-Gutiérrez, and Juan Fernández-Bolaños. 2024. "Health-Promoting Properties of Pectin–Polyphenol Complex Extracted from Olive Oil By-Product Alperujo: Antioxidant, Antiproliferative, and Anti-Inflammatory Activities" Antioxidants 13, no. 9: 1066. https://doi.org/10.3390/antiox13091066

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