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Review

Role of NADPH Oxidases in Stroke Recovery

1
Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, Republic of Korea
2
Department of Medical Science, Konkuk University School of Medicine, Konkuk University, Seoul 05029, Republic of Korea
3
Department of Occupational Therapy, Division of Health, Baekseok University, Cheonan-si 31065, Republic of Korea
4
Department of Rehabilitation Medicine, Konkuk University School of Medicine, Konkuk University, Seoul 05029, Republic of Korea
*
Authors to whom correspondence should be addressed.
Antioxidants 2024, 13(9), 1065; https://doi.org/10.3390/antiox13091065
Submission received: 22 July 2024 / Revised: 27 August 2024 / Accepted: 30 August 2024 / Published: 30 August 2024
(This article belongs to the Special Issue NADPH Oxidases (NOXs))

Abstract

Stroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke. There is growing evidence that NOX inhibition prevents ischemic injury and that the role of NOX in brain damage or recovery depends on specific post-stroke phases. In addition to studies on post-stroke neuroprotection by NOX inhibition, recent reports have also demonstrated the role of NOX in stroke recovery, a critical process for brain adaptation and functional reorganization after a stroke. Therefore, in this review, we investigated the role of NOX in stroke recovery with the aim of integrating preclinical findings into potential therapeutic strategies to improve stroke recovery.
Keywords: stroke; recovery; repair; oxidative stress; NADPH oxidases; angiogenesis; neurogenesis; functional recovery; stroke interventions; stroke with comorbidity stroke; recovery; repair; oxidative stress; NADPH oxidases; angiogenesis; neurogenesis; functional recovery; stroke interventions; stroke with comorbidity

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MDPI and ACS Style

Choi, D.-H.; Choi, I.-A.; Lee, J. Role of NADPH Oxidases in Stroke Recovery. Antioxidants 2024, 13, 1065. https://doi.org/10.3390/antiox13091065

AMA Style

Choi D-H, Choi I-A, Lee J. Role of NADPH Oxidases in Stroke Recovery. Antioxidants. 2024; 13(9):1065. https://doi.org/10.3390/antiox13091065

Chicago/Turabian Style

Choi, Dong-Hee, In-Ae Choi, and Jongmin Lee. 2024. "Role of NADPH Oxidases in Stroke Recovery" Antioxidants 13, no. 9: 1065. https://doi.org/10.3390/antiox13091065

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