The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
Abstract
:1. Introduction
2. Epitope-Based Vaccines Using Bioinformatic Studies
2.1. Viral Vector-Based Vaccines
2.2. Nucleic Acid Vaccines
2.3. Dendrimer–Peptide Complexes
2.4. Gene Therapy Strategies
3. Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristic/ Variant of Concern | Initial Virus | Alpha | Beta | Gamma | Delta | Omicron |
---|---|---|---|---|---|---|
Reproduction number (R0) or transmissibility * | 2.7 [11] | 4.5 [12,13,14] | ≥2 [13,14] | 4 [13,14] | 8 [12,15] | ≥10 [15] |
Ability to evade immune response ** | --- | --- | +++ [16,17] | ++ [16,17] | ++++ [16,17] | +++++ [18,19] |
First reported | December 2019; China | 14 December 2020; United Kingdom | 18 December 2020; South Africa | 2 January 2021; Brazil | 24 March 2021; India | 24 November 2021; South Africa data |
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García-Machorro, J.; Ramírez-Salinas, G.L.; Martinez-Archundia, M.; Correa-Basurto, J. The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus. Vaccines 2022, 10, 1844. https://doi.org/10.3390/vaccines10111844
García-Machorro J, Ramírez-Salinas GL, Martinez-Archundia M, Correa-Basurto J. The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus. Vaccines. 2022; 10(11):1844. https://doi.org/10.3390/vaccines10111844
Chicago/Turabian StyleGarcía-Machorro, Jazmín, Gema Lizbeth Ramírez-Salinas, Marlet Martinez-Archundia, and José Correa-Basurto. 2022. "The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus" Vaccines 10, no. 11: 1844. https://doi.org/10.3390/vaccines10111844