Kinetics of Humoral Immunity against SARS-CoV-2 in Healthcare Workers after the Third Dose of BNT162b2 mRNA Vaccine
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Data Collection
2.3. Detection of Antibodies Anti-(S) RBD
2.4. Detection of Antibodies Anti-Nucleoprotein (N)
2.5. Statistical Analysis
2.6. Ethical Aspects
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | ||
---|---|---|
Gender Male Female | 10 (29.4) 24 (70.6) | N (%) N (%) |
Age ≥50 <50 | 47.0 ± 11.5 15 (44.1) 19 (55.9) | Mean ± SD (years) N (%) N (%) |
Antibody titer at test A | 763.1 ± 687.8 | Mean ± SD (U/mL) |
Antibody titer at test B | 17679.0 ± 6420.0 | Mean ± SD (U/mL) |
Antibody titer at test C | 10919.2 ± 6528.6 | Mean ± SD (U/mL) |
Antibody titer at test C in COVID-19 subjects | 24004.5 ± 1938.3 | Mean ± SD (U/mL) |
Interval test A-3rd dose | 20 ± 16 | Mean ± SD (days) |
Interval 3rd dose-test B | 34 ± 16 | Mean ± SD (days) |
Interval 3rd dose-test C | 124 ± 12 | Mean ± SD (days) |
COVID-19 Subjects | Age | Gender | Interval Test A-3rd Dose (days) | Antibody Titer Test A (U/mL) | Interval 3rd Dose-Test B (days) | Antibody Titer Test B (U/mL) | Interval 3rd Dose-COVID-19 Positivity (days) | Interval 3rd Dose-Test C (days) | Antibody Titer Test C (U/mL) |
---|---|---|---|---|---|---|---|---|---|
COVID#1 | 61 | M | 8 | 750 | 65 | 6651 | 75 | 147 | 23,870 |
COVID#2 | 55 | M | 35 | 508 | 14 | 25,000 | 74 | 138 | 25,000 |
COVID#3 | 55 | F | 42 | 490 | 26 | 13,770 | 70 | 127 | 25,000 |
COVID#4 | 59 | F | 42 | 2362 | 18 | 13,871 | 89 | 126 | 20,157 |
COVID#5 | 42 | F | 5 | 567 | 49 | 25,000 | 61 | 121 | 25,000 |
COVID#6 | 51 | F | 11 | 808 | 46 | 25,000 | 56 | 120 | 25,000 |
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Grassi, T.; Lobreglio, G.; Panico, A.; Rosato, C.; Zizza, A.; Lazzari, R.; Chicone, M.; Indino, F.; Bagordo, F. Kinetics of Humoral Immunity against SARS-CoV-2 in Healthcare Workers after the Third Dose of BNT162b2 mRNA Vaccine. Vaccines 2022, 10, 1948. https://doi.org/10.3390/vaccines10111948
Grassi T, Lobreglio G, Panico A, Rosato C, Zizza A, Lazzari R, Chicone M, Indino F, Bagordo F. Kinetics of Humoral Immunity against SARS-CoV-2 in Healthcare Workers after the Third Dose of BNT162b2 mRNA Vaccine. Vaccines. 2022; 10(11):1948. https://doi.org/10.3390/vaccines10111948
Chicago/Turabian StyleGrassi, Tiziana, Giambattista Lobreglio, Alessandra Panico, Chiara Rosato, Antonella Zizza, Roberta Lazzari, Michele Chicone, Floriano Indino, and Francesco Bagordo. 2022. "Kinetics of Humoral Immunity against SARS-CoV-2 in Healthcare Workers after the Third Dose of BNT162b2 mRNA Vaccine" Vaccines 10, no. 11: 1948. https://doi.org/10.3390/vaccines10111948