Significant Increase in Antibody Titers after the 3rd Booster Dose of the Pfizer–BioNTech mRNA COVID-19 Vaccine in Healthcare Workers in Greece
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N | 9 Months GMC (95% CI) | 9 Months Relative to 6 Months GMC Fold Change (95% CI) | 3rd Dose GMC (95% CI) | 3rd Dose Relative to 6 Months GMC Fold Change | 3rd Dose Relative to 9 Months GMC Fold Change | ||
---|---|---|---|---|---|---|---|
129 | 437.47 (383.34, 499.24) | 0.489 (0.447, 0.535) | 20,231.52 (18,062.02, 22,661.60) | 22.84 (19.77, 26.39) | 46.30 (41.09, 52.17) | ||
SEX | Male | 50 | 464.14 (367.45, 586.26) | 0.452 (0.365, 0.558) | 20,429.62 (17,014.89, 24,529.66) | 20.16 (14.63, 27.79) | 44.02 (35.81, 54.10) |
Female | 79 | 421.39 (358.81, 494.88) | 0.508 (0.464, 0.556) | 20,107.13 (17,344.50, 23,309.79) | 24.24 (20.80, 28.26) | 47.81 (41.23, 55.43) | |
p-value | 0.429 | 0.893 | |||||
AGE | <40 | 19 | 567.45 (395.85, 813.45) | 0.452 (0.386, 0.529) | 22,145.50 (15,643.38, 31,350.21) | 23.46 (16.47, 33.42) | 39.03 (26.28, 57.95) |
40– | 38 | 537.71 (407.08, 710.26) | 0.458 (0.395, 0.531) | 22,948.09 (18,909.49, 27,849.23) | 19.59 (14.87, 25.81) | 42.84 (33.26, 55.19) | |
50– | 53 | 413.07 (346.50, 492.44) | 0.563 (0.476, 0.665) | 19,131.27 (15,858.29, 23,079.75) | 24.83 (19.81, 31.12) | 46.31 (39.12, 54.83) | |
60– | 19 | 261.98 (190.83, 359.66) | 0.420 (0.328, 0.539) | 16791.01 (12,599.75, 22,376.47) | 26.20 (16.95, 40.49) | 64.09 (51.40, 79.91) | |
p-value | 0.002 | 0.294 | |||||
prior COVID status | NO | 110 | 380.49 (335.82, 431.10) | 0.503 (0.457, 0.554) | 19556.40 (17,304.41, 22,101.46) | 26.22 (23.22, 29.62) | 51.47 (46.14, 57.41) |
YES | 19 | 981.29 (668.44, 1440.58) | 0.415 (0.314, 0.548) | 24624.25 (17,959.36, 33,762.55) | 10.25 (5.75, 18.26) | 25.09 (16.09, 39.13) | |
p-value | <0.001 | 0.155 |
COVID after 3rd Dose | N | After 1st Dose | After 2nd Dose | 3 mo after 2nd | 6 mo after 2nd | 9 mo after 2nd | After 3rd Dose | |
---|---|---|---|---|---|---|---|---|
GMC | N | 111 | 460.57 (318.73, 665.53) | 15,585.5 (13,349.04, 18,196.66) | 2945.32 (2467.74, 3515.33) | 890.06 (740.40, 1069.96) | 445.85 (384.56, 516.90) | 19871.33 (17,655.59, 22,365.14) |
Y | 18 | 464.96 (168.03, 1286.57) | 16,433.37 (11,997.75, 22,508.85) | 2408.92 (1722.07, 3369.72) | 783.01 (549.53, 1115.67) | 389.15 (294.80, 513.70) | 22,601.53 (15,275.04, 33,442.08) | |
p-value | 0.985 | 0.793 | 0.382 | 0.573 | 0.482 | 0.439 |
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Kontopoulou, K.; Nakas, C.T.; Papazisis, G. Significant Increase in Antibody Titers after the 3rd Booster Dose of the Pfizer–BioNTech mRNA COVID-19 Vaccine in Healthcare Workers in Greece. Vaccines 2022, 10, 876. https://doi.org/10.3390/vaccines10060876
Kontopoulou K, Nakas CT, Papazisis G. Significant Increase in Antibody Titers after the 3rd Booster Dose of the Pfizer–BioNTech mRNA COVID-19 Vaccine in Healthcare Workers in Greece. Vaccines. 2022; 10(6):876. https://doi.org/10.3390/vaccines10060876
Chicago/Turabian StyleKontopoulou, Konstantina, Christos T. Nakas, and Georgios Papazisis. 2022. "Significant Increase in Antibody Titers after the 3rd Booster Dose of the Pfizer–BioNTech mRNA COVID-19 Vaccine in Healthcare Workers in Greece" Vaccines 10, no. 6: 876. https://doi.org/10.3390/vaccines10060876