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Vaccines
Volume 8
Issue 1
10.3390/vaccines8010041
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Review

Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside

by
Gabriel Siracusano
1,*,
Maria Tagliamonte
2,
Luigi Buonaguro
2 and
Lucia Lopalco
1
1
Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy
2
Cancer Immunoregulation Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori IRCCS, “Fondazione Pascale”, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Vaccines 2020, 8(1), 41; https://doi.org/10.3390/vaccines8010041
Submission received: 31 December 2019 / Revised: 16 January 2020 / Accepted: 22 January 2020 / Published: 24 January 2020
(This article belongs to the Section Cancer Vaccines and Immunotherapy)
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Abstract

Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.
Keywords: hepatocellular carcinoma; cell surface proteins; biomarker; therapeutic target; clinical trial hepatocellular carcinoma; cell surface proteins; biomarker; therapeutic target; clinical trial

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MDPI and ACS Style

Siracusano, G.; Tagliamonte, M.; Buonaguro, L.; Lopalco, L. Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside. Vaccines 2020, 8, 41. https://doi.org/10.3390/vaccines8010041

AMA Style

Siracusano G, Tagliamonte M, Buonaguro L, Lopalco L. Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside. Vaccines. 2020; 8(1):41. https://doi.org/10.3390/vaccines8010041

Chicago/Turabian Style

Siracusano, Gabriel, Maria Tagliamonte, Luigi Buonaguro, and Lucia Lopalco. 2020. "Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside" Vaccines 8, no. 1: 41. https://doi.org/10.3390/vaccines8010041

APA Style

Siracusano, G., Tagliamonte, M., Buonaguro, L., & Lopalco, L. (2020). Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside. Vaccines, 8(1), 41. https://doi.org/10.3390/vaccines8010041

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