The Effect of the PCSK9 Inhibitor Evolocumab on Aldosterone Secretion among High Cardiovascular Risk Patients: A Pilot Study
Abstract
:1. Introduction
2. Patients and Methods
2.1. Study Procedure
2.2. ACTH Stimulation Test
2.3. Assays
2.4. Twenty-Four Hour Ambulatory Blood Pressure Monitoring
2.5. Statistical Analysis
3. Results
3.1. Characteristics of the Study Population
3.2. Changes in Lipid Profile
3.3. Changes in Steroidogenesis
3.4. Changes in 24-Hour ABPM
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variable | Value |
---|---|
Median age, y (Q1–Q3) | 63.8 (59.5–69.6) |
Male, n (%) | 7 (47) |
Body mass index, median (Q1–Q3) | 29.4 (27.7–33.9) |
Weight, kg, median (Q1–Q3) | 86.3 (69.5–97.2) |
Hyperlipidemia, n (%) | 15 (100) |
Diabetes mellitus, n (%) | 6 (40) |
Hypertension, n (%) | 9 (60) |
Past myocardial infarction, n (%) | 9 (60) |
Smoking, n (%) | 1 (7) |
Family history of ischemic heart disease, n (%) | 9 (60) |
Parameter | Baseline Median (Q1–Q3) | End of Study Median (Q1–Q3) | Difference Median (Q1–Q3) | p Value |
---|---|---|---|---|
FBG, mg/dL | 90 (80–107) | 87 (79–98) | −3 (−14–10) | 0.176 |
Potassium, mmol/L | 4.4 (4.2–4.6) | 4.4 (4.2–4.7) | 0 (−0.6–0.3) | 0.889 |
Total cholesterol, mg/dL | 219 (156–247) | 136 (118–162) | −55 (−99–−41) | 0.001 |
HDL cholesterol, mg/dL | 46 (37–64) | 47 (38–59) | 1 (−2–3) | 0.706 |
LDL cholesterol, mg/dL | 127 (93–153) | 63 (43–73) | −65 (−92–−41) | 0.001 |
Triglycerides, mg/dL | 146 (97–190) | 114 (101–181) | 1 (−35–7) | 0.496 |
Lipoprotein (a), mg/dL | 66 (17–92) | 52 (11–83) | −11 (−120–−5) | 0.002 |
Apo A1, mg/dL | 144 (123–172) | 149 (135–158) | 4 (−4–17) | 0.505 |
Apo B100, mg/dL | 117 (74–150) | 65 (51–81) | −50 (−65–−13) | 0.002 |
Parameter | Baseline | End of Study | Difference | p Value |
---|---|---|---|---|
ACTH, pg/mL | ||||
Baseline | 17.6 (6.7–23.4) | 18.0 (11.1–24.1) | 0.1 (−4.1–5.9) | 0.638 |
Cortisol, mcg/dL | ||||
Baseline | 13 (10.3–15.8) | 12.3 (8.9–19.3) | 0.1 (−2.5–1.7) | 0.975 |
30 min | 30 (25.2–32.4) | 28.1 (23.9–37.2 | 0.9 (−2.6–4.3) | 0.552 |
60 min | 33.9 (29.9–38) | 31.1 (28.4–41.1) | −0.1 (−2.4–3.1) | 0.701 |
Aldosterone, ng/dL | ||||
Baseline | 13.9 (6.7–40.4) | 7.9 (5.6–14.5) | −2.9 (−37.6–-0.3) | 0.036 |
30 min | 25.2 (14.6–124.3) | 16.9 (12.0–32.6) | −3.4 (−116.3–−1.1) | 0.008 |
60 min | 21.3 (15.2–78.6) | 16.8 (12.2–29.8) | 3.9 (−36.5–1.1) | 0.064 |
PRA, ng/mL/h | ||||
Baseline | 1.5 (0.8–3.6) | 1.5 (0.8–3.6) | −0.2 (−1.0–0.6) | 0.65 |
30 min | 1.2 (0.3–3.8) | 1.2 (0.3–3.8) | 0.3 (−0.2–1.1) | 0.328 |
60 min | 0.8 (0.6–3) | 0.8 (0.6–3) | −0.2 (−0.7–0.8) | 0.972 |
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Izkhakov, E.; Shacham, Y.; Serebro, M.; Yaish, I.; Marcus, Y.; Shefer, G.; Tordjman, K.; Greenman, Y.; Stern, N.; Ziv-Baran, T. The Effect of the PCSK9 Inhibitor Evolocumab on Aldosterone Secretion among High Cardiovascular Risk Patients: A Pilot Study. J. Clin. Med. 2021, 10, 2504. https://doi.org/10.3390/jcm10112504
Izkhakov E, Shacham Y, Serebro M, Yaish I, Marcus Y, Shefer G, Tordjman K, Greenman Y, Stern N, Ziv-Baran T. The Effect of the PCSK9 Inhibitor Evolocumab on Aldosterone Secretion among High Cardiovascular Risk Patients: A Pilot Study. Journal of Clinical Medicine. 2021; 10(11):2504. https://doi.org/10.3390/jcm10112504
Chicago/Turabian StyleIzkhakov, Elena, Yacov Shacham, Merav Serebro, Iris Yaish, Yonit Marcus, Gabi Shefer, Karen Tordjman, Yona Greenman, Naftali Stern, and Tomer Ziv-Baran. 2021. "The Effect of the PCSK9 Inhibitor Evolocumab on Aldosterone Secretion among High Cardiovascular Risk Patients: A Pilot Study" Journal of Clinical Medicine 10, no. 11: 2504. https://doi.org/10.3390/jcm10112504