Preeclampsia and Cardiovascular Risk for Offspring
, Filip Dziwisz 2, Magdalena Słodzińska 1, Hubert Słodziński 3 and Bożena Leszczyńska-Gorzelak 1Round 1
Reviewer 1 Report
I am please to review this extensive literature review of Pre-eclampsia and the cardiovascular risk for offspring.
The first few sections are much more successful for the reader than the last sections. I am unsure of the word limit for these sorts of articles but overall I would say it could be edited down quite significantly. I found section 5 long and very complicated being unfamiliar with many of the specifics of for example single nucleotide polymorphisms and I think this could be much shorter.
specific comments
line 127
the first paragraph- it is not clear when the BMI was measured- infants, children, adolescents- please clarify
line 187/188 Don't understand - what is a concentric type of modelling?
line 332/333- rephrase this sentence
Are you trying to say more research is needed into the effects of treatment used in the mothers with PE?
line 355- what is 'dams of the adult offspring' ?
line 431/432 Don't understand this sentence - please rephrase
line 455 what is CRISPS - I don't see this defined anywhere
line 562 /563 this sentence needs rephrased to make sense
There are a few minor grammar and spelling issues
ne 506 fetal/fetus instead of foetal/foetal
consistency with spelling e.g. dysfunction not disfunction
line 116 cause defects
line 131 A Turkish study
line 132 higher aortic ...
line 149 confirm
line 209 including basal septal hypertrophy
line 292 take out 'On the other hand ' just start 'PE is known to be ...'
line 358 take out 'Another aspect...' just start 'Prenatal exposure ....'
line 374 take out 'Moreover...' just start 'Models of ..'
line 403 development may increase risk of
line 407 In PE the placenta .....into the maternal circulation ...'
line 503 first two sentences need rephrasing e.g. 'Several important papers have been published on the role etc . One examined ...'
the diagram page 13 added nothing at all to the paper
Author Response
Dear Reviewer,
Thank you very much for your valuable and thoughtful comments. We find all your remarks spot on therefore we have made a point-by-point correction of the manuscript according to your suggestions. We have rearranged our manuscript. We have reduced the section entitled “Genetics”.
specific comments
line 127
the first paragraph- it is not clear when the BMI was measured- infants, children, adolescents- please clarify
Following your advice, we have corrected:
“A meta-analysis of 8 studies with 39611 participants children, adolescents and young adults showed a significant increase of 0.57 kg in offspring of preeclamptic women.”
line 187/188 Don't understand - what is a concentric type of modelling?
A concentric type of remodeling is one of types of ventricular remodeling. It generally exhibits a trend toward higher left ventricular (LV) mass than is seen with a truly normal geometry; it appears to be an early response to a LV pressure overload.
We have rearranged this sentence as follows:
“A study of Timka et al. using echocardiography in 1592 adolescent subjects reported a concentric type of remodeling, which means the increased relative wall thickness (RWT) and reduced left ventricular end‐diastolic volume (LVED) [44].”
line 332/333- rephrase this sentence
Are you trying to say more research is needed into the effects of treatment used in the mothers with PE?
Following your advice, we have corrected:
“More research is needed into the effects of treatment used in the mothers with PE.”
line 355- what is 'dams of the adult offspring ?
We have replaced “dams” by “female rats”
line 431/432 Don't understand this sentence - please rephrase
The sentence was removed.
line 455 what is CRISPS - I don't see this defined anywhere
The word “CRISPS” was removed.
line 562 /563 this sentence needs rephrased to make sense
Following your advice, we have rephrased:
“The role of genetics, inheritance and epigenetics has been convincingly confirmed. above, yet, it cannot be responsibly isolated for the severity and type of inherited susceptibility to disease. Nevertheless, it is impossible to accurately determine the severity and type of inherited susceptibility to the disease.”
There are a few minor grammar and spelling issues
ne 506 fetal/fetus instead of foetal/foetal
We have replaced “foetal/foetus” by “fetal/fetus”
consistency with spelling e.g. dysfunction not disfunction
The sentence with the word “disfunction” was removed.
line 116 cause defects
It was corrected.
line 131 A Turkish study
It was corrected.
line 132 higher aortic ...
It was corrected.
line 149 confirm
It was corrected.
line 209 including basal septal hypertrophy
It was corrected.
line 292 take out 'On the other hand ' just start 'PE is known to be ...'
It was corrected.
line 358 take out 'Another aspect...' just start 'Prenatal exposure ....'
It was corrected.
line 374 take out 'Moreover...' just start 'Models of ..'
It was corrected.
line 403 development may increase risk of
It was corrected.
line 407 In PE the placenta .....into the maternal circulation ...'
It was corrected.
line 503 first two sentences need rephrasing e.g. 'Several important papers have been published on the role etc . One examined ...'
It was corrected.
the diagram page 13 added nothing at all to the paper
We have decided to delete Figure 1 from the text of our manuscript. This figure could be a graphical abstract.
We would like to take this opportunity to thank the Reviewers and Editors for all the valuable and highly perceptive remarks which have definitely made a substantial contribution to the quality of our paper. Some English language issues have been corrected.
Thank you for considering our manuscript for publication. We appreciate your time and look forward to hearing from you.
Yours faithfully,
Assoc. Prof. Zaneta Kimber-Trojnar, M.D., Ph.D.
Chair and Department of Obstetrics and Perinatology
Medical University of Lublin
Jaczewskiego 8, 20-090 Lublin, Poland
Tel: +48 81 7244 769;
Fax: +48 81 7244 841
E-mail: zkimber@poczta.onet.pl
Author Response File: 
Author Response.docx
Reviewer 2 Report
Dear Mr Editor in chief,
Thank you for asking me to review the manuscript Manuscript ID: jcm-1260128 entitled “CPreeclampsia and cardiovascular risk for offspring”, which was submitted to the International Journal of Obstetrics & Gynecology,
https://www.mdpi.com/journal/jcm/sections/Obstetrics_Gynecology.
After reading the manuscript,I strongly believe that this paper met the basic criteria to be considered as well written. I would like to recommend it for publication .
Author Response
Dear Reviewer,
Thank you very much for finding the time to read our manuscript. Thank you for considering our manuscript.
Yours faithfully,
Assoc. Prof. Zaneta Kimber-Trojnar, M.D., Ph.D.
Chair and Department of Obstetrics and Perinatology
Medical University of Lublin
Jaczewskiego 8, 20-090 Lublin, Poland
Tel: +48 81 7244 769;
Fax: +48 81 7244 841
E-mail: zkimber@poczta.onet.pl
