Evaluation of Radiographic Contrast-Induced Nephropathy by Functional Diffusion Weighted Imaging
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Collective
2.2. MRI Protocol
2.3. Post-Processing
2.4. Clinical Parameters
2.5. Statistical Analysis
3. Results
3.1. Clinical Characteristics
3.2. MRI Parameters
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patient. | Gender | Age | XCM | Weight | AKIN Stage of | eGFR | Cystatin C | Creatinine | NGAL | DKK-3 | KIM-1 | TIMP-2 | IGFBP7 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# | (mL) | (kg) | CIN | (mL/min) | (mg/L) | (mg/dL) | (ng/mL) | (ng/mL) | (ng/mL) | (ng/mL) | (ng/mL) | |||
1 | M | 77 | 162 | 69 | - | Pre | 64 | 1.66 | 1.11 | - | - | - | - | - |
Post | 50 | 1.99 | 1.35 | - | - | - | - | - | ||||||
2 | F | 77 | 200 | 86 | III | Pre | 26 | 2.22 | 1.84 | - | - | - | - | - |
Post | 0 | 3.18 | 4.57 | - | - | - | - | - | ||||||
3 | F | 80 | 80 | 50 | - | Pre | 68 | 1.18 | 0.82 | 7.911 | 0.930 | 0.215 | 0.531 | 0.125 |
Post | 77 | 1.19 | 0.74 | 23.730 | 1.096 | 0.897 | 1.260 | 0.212 | ||||||
4 | M | 83 | 135 | 82 | I | Pre | 41 | 1.84 | 1.55 | 10.002 | 0.000 | 0.063 | 0.016 | 0.026 |
Post | 29 | 1.89 | 2.07 | 55.970 | 0.148 | 0.268 | 0.551 | 0.096 | ||||||
5 | F | 79 | 160 | 62 | - | Pre | 51 | 1.31 | 1.08 | 26.253 | 0.040 | 0.236 | 0.300 | 0.191 |
Post | 59 | 1.17 | 0.88 | 164.211 | 0.269 | 1.629 | 0.799 | 0.794 | ||||||
6 | M | 71 | 130 | 143 | - | Pre | 50 | 1.85 | 1.41 | 10.699 | 0.523 | 1.102 | 1.035 | 0.200 |
Post | 52 | 1.77 | 1.38 | 50.213 | 1.321 | 3.547 | 1.260 | 0.794 | ||||||
7 | M | 78 | 190 | 82 | - | Pre | 53 | 1.57 | 1.28 | 30.174 | 0.005 | 0.000 | 0.027 | 0.000 |
Post | 54 | 1.55 | 1.26 | 150.336 | 4.197 | 0.933 | 1.260 | 0.228 | ||||||
8 | M | 60 | 69 | 115 | - | Pre | 39 | 1.76 | 1.82 | 27.594 | 0.202 | 0.308 | 0.489 | 0.051 |
Post | 41 | 1.68 | 1.76 | 53.215 | 0.358 | 1.204 | 0.729 | 0.432 | ||||||
9 | M | 76 | 140 | 80 | - | Pre | 82 | 1.26 | 0.91 | 3.757 | 0.036 | 0.000 | 0.000 | 0.000 |
Post | 83 | 1.27 | 0.88 | 35.355 | 0.624 | 0.630 | 0.831 | 0.018 | ||||||
10 | F | 77 | 144 | 70 | I | Pre | 63 | 1.60 | 0.89 | 23.612 | 0.000 | 0.000 | 0.025 | 0.000 |
Post | 42 | 2.04 | 1.23 | 184.652 | 1.783 | 0.154 | 1.260 | 0.277 | ||||||
11 | M | 54 | 290 | 100 | - | Pre | 27 | 2.50 | 2.57 | - | 0.000 | - | 0.000 | 0.511 |
Post | 33 | 2.03 | 2.18 | - | 0.535 | - | 0.982 | 0.799 | ||||||
12 | M | 81 | 90 | 79 | I | Pre | 30 | 3.46 | 2.00 | - | 0.000 | - | 0.557 | 0.639 |
Post | 22 | 4.52 | 2.59 | - | 0.879 | - | 1.013 | 0.989 | ||||||
13 | M | 84 | 160 | 72 | I | Pre | 71 | 1.37 | 0.97 | - | 0.000 | - | 0.492 | 0.991 |
Post | 49 | 1.93 | 1.33 | - | 2.471 | - | 1.109 | 2.156 | ||||||
14 | M | 81 | 145 | 96 | - | Pre | 62 | 1.37 | 1.11 | - | - | - | - | - |
Post | 69 | 1.31 | 1.02 | - | - | - | - | - | ||||||
15 | F | 80 | 227 | 58 | - | Pre | 42 | 1.22 | 1.16 | - | - | - | - | - |
Post | 46 | 1.49 | 1.14 | - | - | - | - | - |
ADC (×10−3 mm2/s) | FA (a.u.) | ||||
---|---|---|---|---|---|
Cortex | Medulla | Cortex | Medulla | ||
non-CIN (n = 10) | pre | 1795.7 ± 114.8 | 1859.2 ± 204.7 | 0.27 ± 0.06 | 0.29 ± 0.08 |
post | 1753.2 ± 176.0 | 1793.6 ± 165.2 | 0.26 ± 0.06 | 0.27 ± 0.06 | |
CIN (n = 5) | pre | 1868.2 ± 38.4 | 1880.6 ± 51.2 | 0.26 ± 0.10 | 0.28 ± 0.07 |
post | 1706.2 ± 72.4 | 1703.2 ± 90.7 | 0.21 ± 0.12 | 0.21 ± 0.07 |
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Thiel, T.A.; Schweitzer, J.; Xia, T.; Bechler, E.; Valentin, B.; Steuwe, A.; Boege, F.; Westenfeld, R.; Wittsack, H.-J.; Ljimani, A. Evaluation of Radiographic Contrast-Induced Nephropathy by Functional Diffusion Weighted Imaging. J. Clin. Med. 2021, 10, 4573. https://doi.org/10.3390/jcm10194573
Thiel TA, Schweitzer J, Xia T, Bechler E, Valentin B, Steuwe A, Boege F, Westenfeld R, Wittsack H-J, Ljimani A. Evaluation of Radiographic Contrast-Induced Nephropathy by Functional Diffusion Weighted Imaging. Journal of Clinical Medicine. 2021; 10(19):4573. https://doi.org/10.3390/jcm10194573
Chicago/Turabian StyleThiel, Thomas Andreas, Julian Schweitzer, Taogetu Xia, Eric Bechler, Birte Valentin, Andrea Steuwe, Friedrich Boege, Ralf Westenfeld, Hans-Jörg Wittsack, and Alexandra Ljimani. 2021. "Evaluation of Radiographic Contrast-Induced Nephropathy by Functional Diffusion Weighted Imaging" Journal of Clinical Medicine 10, no. 19: 4573. https://doi.org/10.3390/jcm10194573