Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years
Abstract
:1. Introduction
2. Methods
2.1. Definitions
2.2. Study Population
2.3. Comparator Population
2.4. Statistical Methods
2.5. Sample Size Calculation
2.6. Ethical Approval
3. Results
3.1. Demographics
3.2. Risk of Metabolic Syndrome in Stone Formers
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
References
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Metabolic Syndrome (Modified AACE Criteria) | |
---|---|
Fasting Plasma Glucose | >6.1 mmol/L or Hypoglycaemic treatment or Physician diagnosis of Impaired Glucose Tolerance or Diabetes Mellitus |
Body Mass Index | ≥25 kg/m2 or Physician diagnosis of Obesity |
Blood Pressure | ≥130/≥85 mmHg or Antihypertensive treatment or Physician diagnosis of hypertension |
Triglycerides | >1.7 mmol/L |
High-Density Lipoprotein | M: <1.04 mmol/L; F: <1.29 mmol/L |
Controls | Stone Formers | HR (95% CI) | p | ||
---|---|---|---|---|---|
Age at Presentation (Years), Mean ± SD | 49 ± 14 | 49 ± 14 | |||
Sex, n (%) | Female | 723 (29.1%) | 241 (29.1%) | ||
Male | 1761 (70.9%) | 587 (70.9%) | |||
Follow-Up (Years), Median (IQR) | 22 (17–27) | 22 (17–27) | |||
Metabolic Syndrome, n (%) | 617 (24.8%) | 361 (43.6%) | 1.77 (1.55–2.03) | <0.001 | |
Metabolic Syndrome Components Developed, n (%) | 0 | 478 (19.2%) | 114 (13.8%) | ||
1 | 793 (31.9%) | 146 (17.6%) | |||
2 | 596 (24.0%) | 172 (20.8%) | |||
3 | 399 (16.1%) | 170 (20.5%) | |||
4 | 182 (7.3%) | 134 (16.2%) | |||
5 | 36 (1.4%) | 83 (1.0%) | |||
Primary Stone Composition, n (%) | Ca Ox | - | 425 (51.3%) | 1.82 (1.53–2.16) | <0.001 |
Urate | - | 21 (2.5%) | 3.87 (2.23–6.72) | <0.001 | |
Ca Po | - | 17 (2.1%) | 0.89 (0.33–2.38) | 0.82 | |
Struvite | - | 5 (0.6%) | 0.78 (0.11–5.54) | 0.80 | |
Unclear | - | 360 (43.5%) | 1.71 (1.43–2.05) | <0.001 |
Component | Unadjusted | Adjusted | ||
---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Impaired Glucose Tolerance | 1.19 (0.97–1.46) | 0.09 | 1.17 (0.95–1.43) | 0.13 |
Hypertension | 1.56 (1.41–1.81) | <0.001 | 1.51 (1.33–1.71) | <0.001 |
BMI > 25 | 1.41 (1.03–1.26) | 0.01 | 1.11 (1.01–1.24) | 0.04 |
TGL > 1.70 | 1.58 (1.37–1.83) | <0.001 | 1.50 (1.30–1.74) | <0.001 |
HDL < 1.04 for women; <1.29 for men | 1.26 (1.09–1.45) | <0.001 | 1.25 (1.09–1.44) | 0.002 |
Metabolic Syndrome | 1.78 (1.56–2.03) | <0.001 | 1.77 (1.55–2.03) | <0.001 |
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Geraghty, R.M.; Cook, P.; Roderick, P.; Somani, B. Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years. J. Clin. Med. 2021, 10, 978. https://doi.org/10.3390/jcm10050978
Geraghty RM, Cook P, Roderick P, Somani B. Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years. Journal of Clinical Medicine. 2021; 10(5):978. https://doi.org/10.3390/jcm10050978
Chicago/Turabian StyleGeraghty, Robert M., Paul Cook, Paul Roderick, and Bhaskar Somani. 2021. "Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years" Journal of Clinical Medicine 10, no. 5: 978. https://doi.org/10.3390/jcm10050978