Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Setting and Population
2.2. Study Procedures
2.3. Statistical Analysis and Sample Size Calculation
2.4. Study Oversight and Ethical Statement
2.5. Microbiology Procedures
2.5.1. SARS-CoV-2 RNA detection
2.5.2. Determination of Humoral Immune Response against SARS-CoV-2
3. Results
3.1. Population Description
3.2. SARS-CoV-2 RNA Detection
3.3. Serology Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
Case Description of the Probable Reinfection Cases
References
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HC (n = 20) | IC Cohort (n = 20) | |
---|---|---|
Age, years | 29 (26–36.75) | 30 (28–34) |
Sex, female | 12 (60%) | 10 (50%) |
Immunosuppression | 0 | 1 (5%) |
Caring for COVID19 patients | 100% | 100% |
Emergency department shifts | 100% | 100% |
Role in the hospital | ||
Physician | 18 (90%) | 19 (95%) |
Nurse | 2 (10%) | 1 (1%) |
Time from first molecular test to inclusion, days | - | 22.5 (18–25) |
Follow up time, days | 49 (49–51) | 49 (49–49) |
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Sánchez-Montalvá, A.; Fernández-Naval, C.; Antón, A.; Durà, X.; Vimes, A.; Silgado, A.; Velásquez-Orozco, F.; Espinosa-Pereiro, J.; Salvador, F.; Pumarola, T.; et al. Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure. J. Clin. Med. 2021, 10, 1968. https://doi.org/10.3390/jcm10091968
Sánchez-Montalvá A, Fernández-Naval C, Antón A, Durà X, Vimes A, Silgado A, Velásquez-Orozco F, Espinosa-Pereiro J, Salvador F, Pumarola T, et al. Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure. Journal of Clinical Medicine. 2021; 10(9):1968. https://doi.org/10.3390/jcm10091968
Chicago/Turabian StyleSánchez-Montalvá, Adrián, Candela Fernández-Naval, Andrés Antón, Xavier Durà, Alba Vimes, Aroa Silgado, Fernando Velásquez-Orozco, Juan Espinosa-Pereiro, Fernando Salvador, Tomás Pumarola, and et al. 2021. "Risk of SARS-CoV-2 Infection in Previously Infected and Non-Infected Cohorts of Health Workers at High Risk of Exposure" Journal of Clinical Medicine 10, no. 9: 1968. https://doi.org/10.3390/jcm10091968