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Article

Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis

by
Jaroslaw Pecold
1,2,
Mahdi Al-Jeabory
1,2,
Maciej Krupowies
2,
Ewa Manka
3,
Adam Smereka
4,
Jerzy Robert Ladny
2,5 and
Lukasz Szarpak
2,6,7,*
1
Department of Trauma and Orthopedic Surgery, Ruda Slaska City Hospital, 41-703 Ruda Slaska, Poland
2
Research Unit, Polish Society of Disaster Medicine, 05-806 Warsaw, Poland
3
Department of Internal Medicine, Angiology and Physical Medicine in Bytom, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland
4
Department of Gastroenterology and Hepatology, Faculty of Medicine, Wroclaw Medical University, 53-126 Wroclaw, Poland
5
Department of Emergency Medicine, Bialystok Medical University, 15-026 Bialystok, Poland
6
Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, 03-411 Warsaw, Poland
7
Research Unit, Maria Sklodowska-Curie Bialystok Oncology Center, 15-027 Bialystok, Poland
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2022, 11(1), 48; https://doi.org/10.3390/jcm11010048
Submission received: 8 December 2021 / Revised: 19 December 2021 / Accepted: 23 December 2021 / Published: 23 December 2021
(This article belongs to the Special Issue Shoulder Arthroplasty: State of the Art and Future Perspectives)
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Abstract

Tranexamic acid (TXA) is an antifibrinolytic agent that has been shown to decrease blood loss and transfusion rates after knee and hip arthroplasty, however with only limited evidence to support its use in shoulder arthroplasty. Therefore, we performed a systematic review and meta-analysis to evaluate the clinical usefulness of tranexamic acid for shoulder arthroplasty. A thorough literature search was conducted across four electronic databases (PubMed, Cochrane Library, Web of Science, Scopus) from inception through to 1 December 2021. The mean difference (MD), odds ratio (OR) or relative risk (RR) and 95% confidence interval (CI) were used to estimate pooled results from studies. Total of 10 studies comprising of 993 patients met the inclusion criteria and were included in the analysis. Blood volume loss in the TXA and non-TXA group was 0.66 ± 0.52 vs. 0.834 ± 0.592 L (MD= −0.15; 95%CI: −0.23 to −0.07; p < 0.001). Change of hemoglobin levels were 2.2 ± 1.0 for TXA group compared to 2.7 ± 1.1 for non-TXA group (MD= −0.51; 95%CI: −0.57 to −0.44; p < 0.001) and hematocrit change was 6.1 ± 2.7% vs. 7.9 ± 3.1%, respectively; (MD= −1.43; 95%CI: −2.27 to −0.59; p < 0.001). Tranexamic acid use for shoulder arthroplasty reduces blood volume loss during and after surgery and reduces drain output and hematocrit change.
Keywords: tranexamic acid; TXA; shoulder; arthroscopy; bleeding; systematic review; meta-analysis tranexamic acid; TXA; shoulder; arthroscopy; bleeding; systematic review; meta-analysis

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MDPI and ACS Style

Pecold, J.; Al-Jeabory, M.; Krupowies, M.; Manka, E.; Smereka, A.; Ladny, J.R.; Szarpak, L. Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. J. Clin. Med. 2022, 11, 48. https://doi.org/10.3390/jcm11010048

AMA Style

Pecold J, Al-Jeabory M, Krupowies M, Manka E, Smereka A, Ladny JR, Szarpak L. Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2022; 11(1):48. https://doi.org/10.3390/jcm11010048

Chicago/Turabian Style

Pecold, Jaroslaw, Mahdi Al-Jeabory, Maciej Krupowies, Ewa Manka, Adam Smereka, Jerzy Robert Ladny, and Lukasz Szarpak. 2022. "Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 11, no. 1: 48. https://doi.org/10.3390/jcm11010048

APA Style

Pecold, J., Al-Jeabory, M., Krupowies, M., Manka, E., Smereka, A., Ladny, J. R., & Szarpak, L. (2022). Tranexamic Acid for Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11(1), 48. https://doi.org/10.3390/jcm11010048

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