Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation?
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Demographic Data
3.2. Outcome Data
3.3. HMP Data
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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SCS (n = 88) | HMP (n = 45) | p | |
---|---|---|---|
Recipient age (years) | 60 [22–80] | 60 [26–81] | 0.9669 |
Recipient male sex (%) | 58.0 | 66.7 | 0.3541 |
Recipient BMI (kg/m2) | 25.9 [18.2–40.0} | 26.2 [18.0–38.2] | 0.8469 |
Dialysis vintage (months) | 76.7 [11.7–159.9] | 84.6 [11.9–186.0] | 0.0310 |
Donor age (years) | 58 [0–85] | 56 [19–84] | 0.8450 |
Donor male sex (%) | 53.4 | 66.7 | 0.1937 |
Donor BMI (kg/m2) | 25.0 [12.8–43.6] | 24.9 [15.2–43.6] | 0.9349 |
KDRI | 1.26 [0.57–2.96] | 1.25 [0.73–2.55] | 0.9783 |
ECD (%) | 50.0 | 48.9 | >0.9999 |
SCS (n = 88) | HMP (n = 45) | p | |
---|---|---|---|
Cold ischemia time (h) | 11.3 [5.4–24.1] | 16.5 [8.5–28.5] | <0.0001 |
0–10 h (%) | 36.4 | 4.4 | |
10–15 h (%) | 40.9 | 20.0 | |
15–20 h (%) | 17.0 | 46.7 | |
>20 h (%) | 5.7 | 28.9 | |
Duration of HMP (h) | n.a. | 10.1 [3.4–18.3] | |
Warm ischemia time [min] | 39 [15–70] | 34 [16–65] | 0.0055 |
DGF (n = 57) | Immediate Function (n = 76) | p | |
---|---|---|---|
Recipient age (years) | 60 [22–81] | 60 [26–80] | 0.5965 |
Recipient male sex (%) | 66.7 | 56.6 | 0.2129 |
Recipient BMI (kg/m2) | 26.7 [18.1–40.0} | 25.3 [18.0–37.7] | 0.0521 |
Dialysis vintage (months) | 80.9 [28.2–150.2] | 77.6 [11.7–186.0] | 0.2537 |
Donor age (years) | 56 [0–85] | 59 [6–85] | 0.5145 |
Donor male sex (%) | 68.4 | 50.0 | 0.0355 |
Donor BMI (kg/m2) | 24.8 [12.8–43.6] | 25.2 [12.8–43.6] | 0.9395 |
KDRI | 1.21 [0.57–2.46] | 1.36 [0.64–2.96] | 0.5160 |
HMP (%) | 33.3 | 34.2 | >0.9999 |
CIT (h) | 13.3 [5.4–28.5] | 13.3 [5.5–26.3] | 0.5064 |
CIT > 15 h (%) | 42.1 | 39.5 | 0.8587 |
WIT [min] | 39 [20–70] | 35 [15–65] | 0.2972 |
Odds Ratio (OR) | 95% Confidence Interval | p | |
---|---|---|---|
Recipient age (per 10 years) | 1.245 | 0.880, 1.762 | 0.216 |
Recipient BMI | 1.072 | 0.991, 1.160 | 0.083 |
Dialysis vintage (per 12 months) | 1.107 | 0.966, 1.268 | 0.143 |
Donor male sex | 2.223 | 1.015, 4.868 | 0.046 |
KDRI | 0.949 | 0.413, 2.183 | 0.903 |
CIT | 1.033 | 0.945, 1.130 | 0.475 |
WIT (per 10 min) | 0.577 | 0.214, 1.557 | 0.277 |
HMP | 1.074 | 0.754, 1.531 | 0.692 |
DGF—SCS (n = 38) | DGF—HMP (n = 19) | p | |
---|---|---|---|
Recipient age (years) | 59 [22–76] | 60 [44–81] | 0.8634 |
Recipient male sex (%) | 60.0 | 83.3 | 0.2359 |
Recipient BMI (kg/m2) | 26.4 [19.7–40.0} | 28.4 [18.1–38.2] | 0.6670 |
Dialysis vintage (days) | 80.7 [28.2–145.4] | 88.0 [28.2–150.2] | 0.1678 |
Donor age (years) | 58 [0–85] | 56 [19–84] | 0.8174 |
Donor male sex (%) | 65.8 | 73.7 | 0.7633 |
Donor BMI (kg/m2) | 24.8 [12.8–36.7] | 24.9 [15.2–43.6] | 0.4370 |
KDRI | 1.23 [0.57–2.21] | 1.17 [0.84–2.46] | 0.9900 |
ECD (%) | 47.4 | 42.1 | 0.7824 |
CIT (h) | 10.9 [5.4–21.2] | 16.3 [12.0–28.5] | <0.0001 |
CIT > 15 h (%) | 26.3 | 73.7 | 0.0014 |
WIT [min] | 40 [22–70] | 33 [20–60] | 0.1876 |
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Weberskirch, S.; Katou, S.; Reuter, S.; Kneifel, F.; Morgul, M.H.; Becker, F.; Houben, P.; Pascher, A.; Vogel, T.; Radunz, S. Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation? J. Clin. Med. 2022, 11, 5698. https://doi.org/10.3390/jcm11195698
Weberskirch S, Katou S, Reuter S, Kneifel F, Morgul MH, Becker F, Houben P, Pascher A, Vogel T, Radunz S. Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation? Journal of Clinical Medicine. 2022; 11(19):5698. https://doi.org/10.3390/jcm11195698
Chicago/Turabian StyleWeberskirch, Sebastian, Shadi Katou, Stefan Reuter, Felicia Kneifel, Mehmet Haluk Morgul, Felix Becker, Philipp Houben, Andreas Pascher, Thomas Vogel, and Sonia Radunz. 2022. "Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation?" Journal of Clinical Medicine 11, no. 19: 5698. https://doi.org/10.3390/jcm11195698