Role of Branched-Chain Amino Acids and Their Derivative β-Hydroxy-β-Methylbutyrate in Liver Cirrhosis
, Alejandro Sanz-Paris 2,3, Vanesa Bernal-Monterde 2,4, Diego Casas-Deza 2,4 and Jose Miguel Arbonés-Mainar 2,5,6,*Round 1
Reviewer 1 Report
The article was presented in a well-structured manner, with an average level of organization. Unfortunately, there are some minor issues. Therefore, the referee suggested that the manuscript should be considerably improved in a minor revision. The following is a list of specific concerns.
Comment 1- There is an issue concerning the ligands of different figures and tables. The ligands should be more detailed.
Comment 2- The significance of liver in metabolism should be included.
Comment 3- The liver cirrhotic patients often suffer from malnutrition and micronutrient deficiencies. It is recommended to include the mechanisms involved in such nutritional alterations faced by liver cirrhotic patients.
Comment 4- Ascites, sarcopenia etc., should be more discussed.
Comment 5- The article’s conclusion should be a detailed conclusion about the state of the field of science to date, with a brief description of achievements, shortcomings, and prospects for future development. It should be expanded.
Author Response
Please see the attachment
Reviewer 2 Report
The review is interesting, very well structured, quite biased. If it is possible, I suggest to add a paragraph that mentions that nutritional supplements are generally rich in leucine due to the type of protein used.
On the other hand, this may be the reason why BCAAs have not really been shown to be superior to nutritional support with regular supplements.
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
