Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. Brain Injury Assessment of MRI
2.3. Developmental Testing
2.4. Evaluation of Behavioral and Emotional Problems
2.5. Outcomes
2.6. Statistics Analysis
2.7. Ethical Issues
3. Results
3.1. Characteristics of the Study Participants
3.2. Primary Outcome
3.3. Secondary Outcomes
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Overall (n = 62) | GBAS Normal (n = 36) | GBAS Mild (n = 24) | GBAS Moderate- Severe (n = 2) | |
---|---|---|---|---|
Females/males | 27/35 | 19/17 | 7/17 | 1/1 |
Gestational age (weeks/days) † | 27/3 (25/2–28/5) | 27/3 (25/1–28/5) | 25/3 (24/2–27/5) | 27/6 (25/5–30/6) |
Birth weight (g) † | 827.5 (676.5–935.75) | 880 (732–955) | 707 (555.25–912.75) | 720 (544–896) |
Apgar score (5 min) † | 6 (3–7) | 6 (5–7.75) | 4 (2–7) | 4.5 (2–7) |
Singleton | 51 (82%) | 30 (83%) | 19 (79%) | 2 (100%) |
Maternal age at delivery † | 33 (28–36.25) | 34 (28–37) | 29 (27.25–35.75) | 38 (33–43) |
Cesarean delivery | 53 (85%) | 32 (89%) | 21 (88%) | 2 (100%) |
Pre-labor rupture of membranes | 21 (34%) | 15 (42%) | 6 (25%) | 0 (0%) |
IVH (≥grade 3) | 4 (6%) | 1 (3%) | 1 (4%) | 2 (100%) |
PVL | 2 (3%) | 1 (3%) | 1 (4%) | 0 (0%) |
CP | 4 (6%) | 1 (3%) | 2 (8%) | 1 (50%) |
ROP treatment | 19 (31%) | 11 (31%) | 7 (29%) | 1 (50%) |
BPD | 39 (63%) | 21 (62%) | 17 (71%) | 1 (50%) |
NEC | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
Sepsis | 4 (6%) | 2 (6%) | 2 (8%) | 0 (0%) |
DQ at Modified 1.5 Years of Age | DQ at 3 Years of Age | |||||
---|---|---|---|---|---|---|
C–A | L–S | P–M | C–A | L–S | P–M | |
GBAS | r = −0.30 (p = 0.021) | r = −0.33 (p = 0.001) | r = −0.37 (p = 0.004) | r = −0.02 (p = 0.87) | r = −0.05 (p = 0.72) | r = −0.14 (p = 0.30) |
Total Difficulties Score | ||
---|---|---|
DQ at modified 1.5 years of age | C–A | r = −0.23 (p = 0.07) |
L–S | r = −0.08 (p = 0.52) | |
P–M | r = 0.00 (p = 0.98) | |
DQ at 3 years of age | C–A | r = −0.17 (p = 0.21) |
L–S | r = 0.05 (p = 0.74) | |
P–M | r = −0.22 (p = 0.10) |
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Taniguchi, A.; Hayakawa, M.; Kataoka, E.; Fujishiro, N.; Sato, Y. Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants. J. Clin. Med. 2022, 11, 772. https://doi.org/10.3390/jcm11030772
Taniguchi A, Hayakawa M, Kataoka E, Fujishiro N, Sato Y. Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants. Journal of Clinical Medicine. 2022; 11(3):772. https://doi.org/10.3390/jcm11030772
Chicago/Turabian StyleTaniguchi, Akinobu, Masahiro Hayakawa, Erina Kataoka, Naozumi Fujishiro, and Yoshiaki Sato. 2022. "Relationship between Neonatal MRI Findings and Emotional/Behavioral Evaluation in Early Childhood for Extremely Low-Birth-Weight Infants" Journal of Clinical Medicine 11, no. 3: 772. https://doi.org/10.3390/jcm11030772