Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study

Risch, Nathan; Dubois, Jonathan; M’bailara, Katia; Cussac, Irena; Etain, Bruno; Belzeaux, Raoul; Dubertret, Caroline; Haffen, Emmanuel; Schwan, Raymund; Samalin, Ludovic; Roux, Paul; Polosan, Mircea; Leboyer, Marion; Courtet, Philippe; Olié, Emilie; on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators,

doi:10.3390/jcm11030893

Open AccessArticle

Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study

by

Nathan Risch

^1,2,3,*

,

Jonathan Dubois

^1,2,

Katia M’bailara

^4,5,6,

Irena Cussac

^4,7,

Bruno Etain

^4,8,9

,

Raoul Belzeaux

^4,10,11,

Caroline Dubertret

^4,12,

Emmanuel Haffen

^4,13

,

Raymund Schwan

^4,14,

Ludovic Samalin

^4,15,

Paul Roux

^4,16

,

Mircea Polosan

^4,17,

Marion Leboyer

^4,18

,

Philippe Courtet

^1,2,4,

Emilie Olié

^1,2,4 and

on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators

^†

¹

Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France

²

Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, 34295 Montpellier, France

³

Clinique de la Lironde, Clinea Psychiatrie, 34980 Saint-Clément-de-Rivière, France

⁴

Fondation FondaMental, 94000 Créteil, France

⁵

LabPsy, University of Bordeaux, EA 4139, F-33000 Bordeaux, France

⁶

Department of Clinical and Academic Psychiatry, Charles-Perrens Hospital, 33076 Bordeaux, France

⁷

Psychiatric Center, Hospital Princesse Grace, 1 Ave. Pasteur, 98000 Monaco, Monaco

⁸

AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Fernand Widal, 75010 Paris, France

⁹

INSERM UMRS 1144-Université de Paris, 75006 Paris, France

¹⁰

Pôle de Psychiatrie, Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France

¹¹

INT-UMR 7289, CNRS Aix-Marseille Université, 13385 Marseille, France

¹²

Department of Psychiatry, University of Paris, AP-HP, Louis Mourier Hospital, INSERM UMR 1266 Paris, 92700 Colombes, France

¹³

Service de Psychiatrie de l’Adulte, CIC-1431 INSERM, CHU de Besançon, Laboratoire de Neurosciences, Université de Franche-Comté, UBFC, 25000 Besançon, France

¹⁴

Université de Lorraine, Centre Psychothérapique de Nancy, Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes du Grand Nancy, INSERM U1254, 54000 Nancy, France

¹⁵

CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, UMR 6602 Institut Pascal (IP), 63178 Clermont-Ferrand, France

¹⁶

Centre Hospitalier de Versailles, Service de Psychiatrie et D’addictologie Adulte, Le Chesnay, EA 4047 HANDIReSP, UFR des Sciences de la Santé Simone Veil, Université Versailles Saint-Quentin-en-Yvelines, Versailles, France and Université Paris-Saclay, UVSQ, Inserm, CESP, Equipe “PsyDev”, 94807 Villejuif, France

¹⁷

Université Grenoble Alpes, Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France

¹⁸

Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires «H. Mondor», DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, F-94010 Creteil, France

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^*

Author to whom correspondence should be addressed.

^†

List of FondaMental Advanced Centre of Expertise (FACE-BD) Collaborators: FACE-BD Clinical Coordinating Center (Fondation FondaMental); B. Etain, E. Olié, M. Leboyer, E. Haffen and P.M. Llorca; FACE-BD Data Coordinating Center (Fondation FondaMental); V. Barteau, S. Bensalem, O. Godin, H. Laouamri and K. Souryis; FACE-BD Clinical Sites and Principal Collaborators in France: AP-HP, Département Médico-Universitaire de psychiatrie et d’addictologie, DMU IMPAACT, Hôpitaux Universitaires H Mondor, Créteil; S. Hotier, A. Pelletier, N. Drancourt, J.P. Sanchez, E. Saliou, C. Hebbache, J. Petrucci, L. Willaume and E. Bourdin; AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Fernand Widal; F. Bellivier, M. Carminati, B. Etain, E. Marlinge, J. Meheust; Hôpital C. Perrens, Centre Expert Trouble Bipolaire, Service de Psychiatrie Adulte, Pôle 3-4-7, Bordeaux; A. Desage, S. Gard, K. M’bailara, I. Minois, J. Sportich and L. Zanouy; Département d’Urgence et Post Urgence Psychiatrique, CHRU Montpellier, Montpellier; L. Bardin, P. Courtet, B. Deffinis, D. Ducasse, M. Gachet, F. Molière, B. Noisette, E. Olié and G. Tarquini; Pôle de Psychiatrie, addictologie et pédopsychiatrie, Hôpital Sainte Marguerite, Assistance Publique Hôpitaux de Marseille; R. Belzeaux, F. Groppi, E. Moreau, A. Lefrere, L. Lescalier, I. Muraccioli and N. Viglianese; Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de Brabois, Vandoeuvre Les Nancy; T. Schwitzer, R. Cohen, M. Milazzo and O. Wajsbrot-Elgrabli; Service Universitaire de Psychiatrie, CHU de Grenoble et des Alpes, Grenoble; T. Bougerol, B. Fredembach, A. Suisse, B. Halili, A. Pouchon and M. Polosan; Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie d’adultes, Le Chesnay; A.M. Galliot, I. Grévin, A.S. Cannavo, N. Kayser, C. Passerieux and P. Roux; Service de Psychiatrie, Centre Hospitalier Princesse Grace, Monaco; V. Aubin, I. Cussac, M.A Dupont, J. Loftus and I. Medecin; Service de psychiatrie et addictologie, Hôpital Louis Mourier, Colombes, AHPH, Groupe Hospitalo-universitaire AP-HP Nord, DMU ESPRIT France: C. Dubertret, N. Mazer, C. Portalier, C. Scognamiglio, A. Bing; Service de Psychiatrie de l’adulte B, Centre Expert Trouble Bipolaire, CHU de Clermont-Ferrand, Clermont-Ferrand, France: P.M. Llorca, L. Samalin, C. Moreau, D. Lacelle, S. Pires, C. Doriat and O. Blanc.

J. Clin. Med. 2022, 11(3), 893; https://doi.org/10.3390/jcm11030893

Submission received: 7 December 2021 / Revised: 24 January 2022 / Accepted: 1 February 2022 / Published: 8 February 2022

(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)

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Abstract

In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective study used data on 880 patients with BD from the French FACE-BD cohort who were divided into two groups according to the presence or absence of pain. Multivariate models were used to test whether pain was associated with affective states and personality traits while controlling for confounders. Then, multivariate models were used to test whether pain at baseline predicted global life functioning and depressive symptomatology at one year. At baseline, 22% of patients self-reported pain. The pain was associated with depressive symptomatology, levels of emotional reactivity in a quadratic relationship, and a composite variable of personality traits (affective lability, affective intensity, hostility/anger, and impulsivity). At one year, the pain was predictive of depression and lower global life functioning. Pain worsens mental health and well-being in patients with BD. The role of emotions, depression, and personality traits in pain has to be elucidated to better understand the high prevalence of pain in BD and to promote specific therapeutic strategies for patients experiencing pain.

Keywords: pain; depression; affective symptoms; bipolar disorder

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MDPI and ACS Style

Risch, N.; Dubois, J.; M’bailara, K.; Cussac, I.; Etain, B.; Belzeaux, R.; Dubertret, C.; Haffen, E.; Schwan, R.; Samalin, L.; et al. Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study. J. Clin. Med. 2022, 11, 893. https://doi.org/10.3390/jcm11030893

AMA Style

Risch N, Dubois J, M’bailara K, Cussac I, Etain B, Belzeaux R, Dubertret C, Haffen E, Schwan R, Samalin L, et al. Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study. Journal of Clinical Medicine. 2022; 11(3):893. https://doi.org/10.3390/jcm11030893

Chicago/Turabian Style

Risch, Nathan, Jonathan Dubois, Katia M’bailara, Irena Cussac, Bruno Etain, Raoul Belzeaux, Caroline Dubertret, Emmanuel Haffen, Raymund Schwan, Ludovic Samalin, and et al. 2022. "Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study" Journal of Clinical Medicine 11, no. 3: 893. https://doi.org/10.3390/jcm11030893

APA Style

Risch, N., Dubois, J., M’bailara, K., Cussac, I., Etain, B., Belzeaux, R., Dubertret, C., Haffen, E., Schwan, R., Samalin, L., Roux, P., Polosan, M., Leboyer, M., Courtet, P., Olié, E., & on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators. (2022). Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study. Journal of Clinical Medicine, 11(3), 893. https://doi.org/10.3390/jcm11030893

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Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study

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