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Volume 12
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10.3390/jcm12247599
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Case Report

Alveolar Ridge Preservation with a Novel Cross-Linked Collagen Sponge: Histological Findings from a Case Report

by
Roberto Abundo
1,*,
Claudia Paola Bruna Dellavia
2,
Elena Canciani
3,
Monica Daniele
4,
Mario Dioguardi
4,
Marta Zambelli
5,
Michele Perelli
6 and
Filiberto Mastrangelo
4,*
1
Independent Researcher, 10133 Turin, Italy
2
Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20126 Milan, Italy
3
Microscopic Anatomy, University of Milan, 20126 Milan, Italy
4
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
5
Independent Researcher, 10133 Turin, Italy
6
Independent Researcher, 10122 Turin, Italy
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2023, 12(24), 7599; https://doi.org/10.3390/jcm12247599
Submission received: 28 November 2023 / Accepted: 5 December 2023 / Published: 10 December 2023
(This article belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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Abstract

Alveolar ridge preservation (ARP) is a well-documented procedure to maintain bone volume after tooth extraction in order to place implants. However, at the end of the healing process, the residual biomaterial that is not reabsorbed remains embedded in the bone over time. Ribose cross-linked biomaterials demonstrated their ability to promote osteoconduction and complete resorption. The aim of this study was to evaluate the histological healing pattern of a novel ribose cross-linked collagen sponge used as a grafting material left exposed in human sockets at the time of tooth extraction. On a single patient, non-restorable lower first molars were extracted on both sides, and a ribose cross-linked collagen sponge was placed bilaterally in the cavities and left uncovered at the end of the surgery. After six months, core biopsies were taken immediately prior to implant placement; after the sample preparation, a histological analysis was performed. The results are very promising for substitution with newly formed bone and the amount of residual material. Ribose cross-linked collagen sponge could represent a valid alternative to conventional biomaterials for ARP procedures with no need for flap advancement and/or the addition of a membrane to cover the graft, reducing the invasiveness, complexity, and costs of the treatment.
Keywords: alveolar ridge augmentation; bone regeneration; biomaterials; cross-linked collagen alveolar ridge augmentation; bone regeneration; biomaterials; cross-linked collagen

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MDPI and ACS Style

Abundo, R.; Dellavia, C.P.B.; Canciani, E.; Daniele, M.; Dioguardi, M.; Zambelli, M.; Perelli, M.; Mastrangelo, F. Alveolar Ridge Preservation with a Novel Cross-Linked Collagen Sponge: Histological Findings from a Case Report. J. Clin. Med. 2023, 12, 7599. https://doi.org/10.3390/jcm12247599

AMA Style

Abundo R, Dellavia CPB, Canciani E, Daniele M, Dioguardi M, Zambelli M, Perelli M, Mastrangelo F. Alveolar Ridge Preservation with a Novel Cross-Linked Collagen Sponge: Histological Findings from a Case Report. Journal of Clinical Medicine. 2023; 12(24):7599. https://doi.org/10.3390/jcm12247599

Chicago/Turabian Style

Abundo, Roberto, Claudia Paola Bruna Dellavia, Elena Canciani, Monica Daniele, Mario Dioguardi, Marta Zambelli, Michele Perelli, and Filiberto Mastrangelo. 2023. "Alveolar Ridge Preservation with a Novel Cross-Linked Collagen Sponge: Histological Findings from a Case Report" Journal of Clinical Medicine 12, no. 24: 7599. https://doi.org/10.3390/jcm12247599

APA Style

Abundo, R., Dellavia, C. P. B., Canciani, E., Daniele, M., Dioguardi, M., Zambelli, M., Perelli, M., & Mastrangelo, F. (2023). Alveolar Ridge Preservation with a Novel Cross-Linked Collagen Sponge: Histological Findings from a Case Report. Journal of Clinical Medicine, 12(24), 7599. https://doi.org/10.3390/jcm12247599

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