Transperineal Laser Ablation of the Prostate (TPLA) for Lower Urinary Tract Symptoms Due to Benign Prostatic Obstruction
, Giampaolo Siena 3, Claudio Bisegna 1, Mattia Lo Re 1, Pietro Spatafora 1, Alessio Pecoraro 1, Anna Rivetti 1, Luisa Moscardi 1, Marco Saladino 1, Andrea Cocci 2,3, Mauro Gacci 1, Vincenzo Li Marzi 1, Marco Carini 3, Andrea Minervini 2,3, Riccardo Campi 1,2,‡ and Sergio Serni 1,2,‡
Round 1
Reviewer 1 Report
It's a well written review on currently available minimal invasive TPLA for BPO data, which is an interesting upcoming technique.
In order to improve the manuscript it is advised:
- to write a systematic review to create a more scientifically robust review. This would improve search strategy yield (for example use of Embase and include conference article data of current trials), structured outcome analysis, heterogeneity and risk of bias analysis.
- to include other laser systems performing transperineal laser ablation for BPO.
- to create a graphical illustration of most important outcomes, such as IPSS, IIEF, uroflowmetry; for readability.
- to perform English spell check.
Author Response
Please see the attachment
Author Response File: 
Author Response.docx
Reviewer 2 Report
The authors have done a comprehensive review regarding TPLA. I have went through their manuscript with interest, without finding any readability issues
Despite the fact that this is an interesting article, its methodology is weak. I would restructure it as a systematic review, adding a flow chart and other things that are missing in its current form.
Although an interesting article, it doesn't add anything to current literature around TPLA.
Author Response
Please see the attachment.
Author Response File: Author Response.docx
Round 2
Reviewer 2 Report
An improved manuscript.
