Blastocyst Transplantation Strategies in Women of Different Ages
, Yongqi Fan 1,2, Yunxia Cao 1,2,*, Zhiguo Zhang 1,2,3,* and Beili Chen 1,2,*Round 1
Reviewer 1 Report
This comprehensive and retrospective study provided valuable information on SBT and DBT use in clinical practice.
Please correct line 35: "in the past days" with the appropriate timing (perhaps years?).
Question for the authors: Did you find any correlations between your data and PGT/PGD results?
Author Response
We thank the reviewer for careful review and insightful comments on our manuscript entitled “Blastocyst transplantation strategies in women of different ages” (Manuscript ID: jcm-2163034).
The original manuscript has been carefully revised based on the reviewer’s comments and concerns. The following is the point-by-point response.
- Thank you for your comment, we have corrected the manuscript in the appropriate places: correct “However, multiple embryos were transferred to increase the clinical pregnancy rate and live birth rate per embryo transfer cycle in the past days” (line 34-35) to “However, multiple embryos were transferred to increase the clinical pregnancy rate and live birth rate per embryo transfer cycle over the past several decades.” (line 34-35).
- Thank you for your suggestion. In fact, to avoid sample selection bias, PGD/PGT cycles were not included in this study. Because we clinically transplanted only single blastocyst that was biopsied for patients in PGD/PGT cycles. In future studies, we will try to explore the transplantation strategy in PGD/PGT patients with reference to your suggestion.
Reviewer 2 Report
1. Line 68. A total of 5477 cycles were enrolled…
How many patients are included in this study? There are repeat cycles?
2. Line 77. And oocyte retrieval was completed after 24–36h by a transvaginal ultrasound.
The correct time of oocyte retrieval should be explained.
3. Statistical analysis: In this study, t-test was used to analyze two independent samples. Are these data normally distributed?
4. Statistical analysis: The day of transferred blastocysts is not analyzed in this study. The day and quality of transferred blastocyst should be included as a confounding factor for pregnancy outcomes in regression analyses.
5. Statistical analysis: If repeated cycles were present in this study, GEE regression should be an appropriate method of analysis.
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
