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Article

Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation

by
Tomasz Gasior
1,†,
Felix J. Woitek
1,†,
Antonia Schroth
1,
Mohamed Abdel-Wahab
2,
Lisa Crusius
1,
Stephan Haussig
1,
Philipp Kiefer
3,
Piotr Scislo
4,
Zenon Huczek
4,
Maciej Dabrowski
5,
Adam Witkowski
5,
Anna Olasinska-Wisniewska
6,
Marek Grygier
7,
Marcin Protasiewicz
8,
Damian Hudziak
9,
Utz Kappert
10,
David Holzhey
11,
Wojtek Wojakowski
12,
Axel Linke
1 and
Norman Mangner
1,*
1
Department of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, Germany
2
Department of Cardiology, Heart Center Leipzig, University Hospital, 04289 Leipzig, Germany
3
Department of Cardiac Surgery, Heart Center Leipzig, University Hospital, 04289 Leipzig, Germany
4
1st Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland
5
Department of Interventional Cardiology and Angiology, National Institute of Cardiology, 04-628 Warsaw, Poland
6
Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
7
1st Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
8
Institute of Heart Diseases, Wroclaw Medical University, ul. Borowska 213, 50-556 Wroclaw, Poland
9
Department of Cardiac Surgery, Medical University of Silesia, 40-055 Katowice, Poland
10
Department of Cardiac Surgery, Herzzentrum Dresden, Technische Universität Dresden, 01307 Dresden, Germany
11
Department of Cardiac Surgery, Helios University Hospital Wuppertal, 42117 Wuppertal, Germany
12
Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, 40-055 Katowice, Poland
 
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*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Clin. Med. 2023, 12(5), 1817; https://doi.org/10.3390/jcm12051817
Submission received: 1 February 2023 / Revised: 20 February 2023 / Accepted: 22 February 2023 / Published: 24 February 2023
(This article belongs to the Special Issue Multidisciplinary Endocarditis Perspectives)
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Abstract

Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are enterococci (EC-IE) and staphylococci (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patients from 2007 to 2021 were included in this analysis. The 1-year mortality was the primary outcome measure of this retrospective multi-center analysis. Results: Out of 163 patients, 53 (32.5%) EC-IE and 69 (42.3%) SC-IE patients were included. Subjects were comparable with regard to age, sex, and clinically relevant baseline comorbidities. Symptoms at admission were not significantly different between groups, except for a lower risk for presenting with septic shock in EC-IE than SC-IE. Treatment was performed in 78% by antibiotics alone and in 22% of patients by surgery and antibiotics, with no significant differences between groups. The rate of any complication, in particular heart failure, renal failure, and septic shock during treatment for IE, was lower in EC-IE compared with SC-IE (p < 0.05). In-hospital (EC-IE: 36% vs. SC-IE: 56%, p = 0.035) and 1-year mortality (EC-IE: 51% vs. SC-IE: 70%, p = 0.009) were significantly lower in EC-IE compared with SC-IE. Conclusions: EC-IE, compared with SC-IE, was associated with a lower morbidity and mortality. However, absolute numbers are high, a finding that should trigger further research in appropriate perioperative antibiotic management and improvement of early IE diagnosis in the case of clinical suspicion.
Keywords: TAVI; infective endocarditis; staphylococci; enterococci; prosthetic valve TAVI; infective endocarditis; staphylococci; enterococci; prosthetic valve
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MDPI and ACS Style

Gasior, T.; Woitek, F.J.; Schroth, A.; Abdel-Wahab, M.; Crusius, L.; Haussig, S.; Kiefer, P.; Scislo, P.; Huczek, Z.; Dabrowski, M.; et al. Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation. J. Clin. Med. 2023, 12, 1817. https://doi.org/10.3390/jcm12051817

AMA Style

Gasior T, Woitek FJ, Schroth A, Abdel-Wahab M, Crusius L, Haussig S, Kiefer P, Scislo P, Huczek Z, Dabrowski M, et al. Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation. Journal of Clinical Medicine. 2023; 12(5):1817. https://doi.org/10.3390/jcm12051817

Chicago/Turabian Style

Gasior, Tomasz, Felix J. Woitek, Antonia Schroth, Mohamed Abdel-Wahab, Lisa Crusius, Stephan Haussig, Philipp Kiefer, Piotr Scislo, Zenon Huczek, Maciej Dabrowski, and et al. 2023. "Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation" Journal of Clinical Medicine 12, no. 5: 1817. https://doi.org/10.3390/jcm12051817

APA Style

Gasior, T., Woitek, F. J., Schroth, A., Abdel-Wahab, M., Crusius, L., Haussig, S., Kiefer, P., Scislo, P., Huczek, Z., Dabrowski, M., Witkowski, A., Olasinska-Wisniewska, A., Grygier, M., Protasiewicz, M., Hudziak, D., Kappert, U., Holzhey, D., Wojakowski, W., Linke, A., & Mangner, N. (2023). Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation. Journal of Clinical Medicine, 12(5), 1817. https://doi.org/10.3390/jcm12051817

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