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Journal of Clinical Medicine, Volume 12, Issue 5

March-1 2023 - 377 articles

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Cover Story: Mutational activation of the epidermal growth factor receptor (EGFR) is a frequent event in non-small cell lung cancer (NSCLC) that contributes to malignant growth. These bona fide driver mutations are important therapeutic targets. While on-target mutations that prevent EGFR inhibitor (EGFRi) binding are a frequent complication, mutational activation of bypass pathways can occur as well. Therapeutic intervention is complicated by an additional duality of resistance mechanisms that are not only mutational but can also include a significant amount of nonmutational activation. Thus, precision medicine takes center stage in defining therapeutic intervention and future drug development. To overcome resistance, we must arrive at therapeutics to encompass both genetic and nongenetic mechanisms. View this paper

Articles (377)

  • Opinion
  • Open Access
11 Citations
3,775 Views
11 Pages

Low- vs. High-Power Laser for Holmium Laser Enucleation of Prostate

  • Vasileios Gkolezakis,
  • Bhaskar Kumar Somani and
  • Theodoros Tokas

6 March 2023

Holmium laser enucleation of the prostate (HoLEP) constitutes an established technique for treating patients with symptomatic bladder outlet obstruction. Most surgeons perform surgeries using high-power (HP) settings. Nevertheless, HP laser machines...

  • Article
  • Open Access
2 Citations
2,173 Views
6 Pages

6 March 2023

Background: We have previously reported that the incidence of postoperative conduction disorders, especially left bundle branch block (LBBB), after implantation of a rapid deployment Intuity™ Elite aortic valve prosthesis (Edwards Lifesciences,...

  • Review
  • Open Access
11 Citations
3,750 Views
15 Pages

Antiplatelet Strategies for Older Patients with Acute Coronary Syndromes: Finding Directions in a Low-Evidence Field

  • Stefano De Servi,
  • Antonio Landi,
  • Stefano Savonitto,
  • Nuccia Morici,
  • Leonardo De Luca,
  • Claudio Montalto,
  • Gabriele Crimi,
  • Roberta De Rosa and
  • Giuseppe De Luca

6 March 2023

Patients ≥ 75 years of age account for about one third of hospitalizations for acute coronary syndromes (ACS). Since the latest European Society of Cardiology guidelines recommend that older ACS patients use the same diagnostic and interventional...

  • Article
  • Open Access
4 Citations
5,023 Views
18 Pages

Brace-Free Rehabilitation after Isolated Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autograft Is Not Inferior to Brace-Based Rehabilitation—A Randomised Controlled Trial

  • Christian Schoepp,
  • Tobias Ohmann,
  • Wolfgang Martin,
  • Arthur Praetorius,
  • Christine Seelmann,
  • Marcel Dudda,
  • Dirk Stengel and
  • Jakob Hax

6 March 2023

Purpose: The postoperative use of a rehabilitative knee brace after isolated primary anterior cruciate ligament (ACL) reconstruction (ACLR) using a hamstring tendon (HT) autograft is controversial. A knee brace may provide subjective safety but can c...

  • Article
  • Open Access
3 Citations
5,146 Views
10 Pages

Surgically Treated pT2aN0M0 (Stage IB) Non-Small Cell Lung Cancer: A 20-Year Single-Center Retrospective Study

  • Monica Casiraghi,
  • Francesco Petrella,
  • Claudia Bardoni,
  • Shehab Mohamed,
  • Giulia Sedda,
  • Juliana Guarize,
  • Antonio Passaro,
  • Filippo De Marinis,
  • Patrick Maisonneuve and
  • Lorenzo Spaggiari

6 March 2023

Introduction The suitability of adjuvant therapy (AT) in patients with stage IB non-small cell lung cancer (NSCLC) is still under debate considering the cost–benefit ratio between improvement in survival and side effects. We retrospectively eva...

  • Article
  • Open Access
2,306 Views
14 Pages

Qualification of Hemophilia Treatment Centers to Enable Multi-Center Studies of Gene Expression Signatures in Blood Cells from Pediatric Patients

  • Birgit M. Reipert,
  • Christoph J. Hofbauer,
  • Bagirath Gangadharan,
  • Verena Berg,
  • Elizabeth Donnachie,
  • Shannon Meeks,
  • Maria Elisa Mancuso,
  • Joel Bowen and
  • Deborah L. Brown

6 March 2023

Hemophilia A is a rare congenital bleeding disorder caused by a deficiency of functionally active coagulation factor VIII (FVIII). Most patients with the severe form of the disease require FVIII replacement therapies, which are often associated with...

  • Article
  • Open Access
5 Citations
4,053 Views
21 Pages

Sleep Quality Disturbances Are Associated with White Matter Alterations in Veterans with Post-Traumatic Stress Disorder and Mild Traumatic Brain Injury

  • Philine Rojczyk,
  • Johanna Seitz-Holland,
  • Elisabeth Kaufmann,
  • Valerie J. Sydnor,
  • Cara L. Kim,
  • Lisa F. Umminger,
  • Tim L. T. Wiegand,
  • Jeffrey P. Guenette,
  • Fan Zhang and
  • Yogesh Rathi
  • + 11 authors

6 March 2023

Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD and mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a comp...

  • Article
  • Open Access
4 Citations
2,284 Views
10 Pages

Quality of Life after Transcatheter Aortic Valve Replacement in Sarcopenic Patients Using the Toronto Aortic Stenosis Quality of Life Questionnaire

  • Gabriele Pesarini,
  • Alessandro Ruzzarin,
  • Matteo Bonatti,
  • Felix Pescoller,
  • Patrick Engl,
  • Rainer Oberhollenzer,
  • Flavio Luciano Ribichini and
  • Luca Donazzan

6 March 2023

Background: Sarcopenia is the core component of frailty; however, its role in patients undergoing transcatheter aortic valve replacement (TAVR) is a matter of debate. The Toronto Aortic Stenosis Quality of Life Questionnaire (TASQ) is a validated ins...

  • Article
  • Open Access
4 Citations
1,622 Views
9 Pages

Gender-Related Outcomes after Surgical Resection and Level of Satisfaction in Patients with Left Atrial Tumors

  • Viyan Sido,
  • Annika Volkwein,
  • Martin Hartrumpf,
  • Christian Braun,
  • Ralf-Uwe Kühnel,
  • Roya Ostovar,
  • Filip Schröter,
  • Sofia Chopsonidou and
  • Johannes Maximilian Albes

6 March 2023

Background: Cardiac tumors are rare, with a low incidence of between 0.0017 and 0.19%. The majority of cardiac tumors are benign and predominantly occur in females. The aim of our study was to examine how outcomes differ between men and women. Method...

  • Article
  • Open Access
6 Citations
4,209 Views
11 Pages

Perimount MAGNA Ease vs. INSPIRIS Resilia Valve: A PS-Matched Analysis of the Hemodynamic Performances in Patients below 70 Years of Age

  • Alessandra Francica,
  • Filippo Tonelli,
  • Cecilia Rossetti,
  • Antonella Galeone,
  • Fabiola Perrone,
  • Giovanni Battista Luciani and
  • Francesco Onorati

6 March 2023

Background: During the past decade, the Perimount Magna Ease (PME) bioprosthesis has been implanted worldwide for aortic valve replacement (AVR). Recently, the INSPIRIS Resilia (IR) valve has been introduced as the newest generation of pericardial bi...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license