The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. IVF Procedures
2.3. Study Outcomes
2.4. Statistical Analysis
3. Results
3.1. Basal Characteristics between Groups
3.2. Outcomes
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Before Matching | After Matching | |||||
---|---|---|---|---|---|---|
Characteristic | Endometrioma Group (n = 664) | Control Group (n = 3133) | SMD | Endometrioma Group (n = 532) | Control Group (n = 532) | SMD |
Age (years) | 31 (28–34) | 32 (29–35) | 0.212 | 31 (29–34) | 31 (28–35) | 0.013 |
BMI (kg/m2) | 22.33 (20.36–24.22) | 23.3 (21.22–25.88) | 0.367 | 22.5 (20.66–24.68) | 22.23 (20.11–25.01) | 0.024 |
Type of infertility | ||||||
Primary | 367 (55.3) | 940 (30.0) | 0.508 | 263 (49.4) | 256 (48.1) | 0.026 |
Secondary | 297 (44.7) | 2193 (70.0) | 0.508 | 269 (50.6) | 276 (51.9) | 0.026 |
Basal FSH (IU/L) | 7.23 (5.99–8.91) | 6.55 (5.6–7.81) | 0.283 | 7.21 (6.00–8.55) | 7 (5.91–8.48) | 0.006 |
Basal LH (IU/L) | 4.84 (3.73–6.17) | 4.5 (3.36–5.88) | 0.122 | 4.76 (3.58–5.97) | 4.52 (3.40–6.09) | 0.010 |
Basal oestradiol (pg/mL) | 37.8 (27.03–52.38) | 33.8 (25.72–45) | 0.195 | 36.90 (26.05–50.78) | 35.60 (25.33–49.08) | 0.007 |
AMH | 1.91 (0.92–3.75) | 2.5 (1.35–4.26) | 0.199 | 1.99 (0.98–3.88) | 2.09 (1.03–3.73) | 0.027 |
AFC | 9 (6–13) | 12 (9–17) | 0.629 | 9 (7–14) | 10 (7–13) | 0.020 |
Sperm concentration (×106/mL) | 60.45 (40.23–84.58) | 59 (39.3–86.1) | 0.030 | 60.25 (40.33–82.5) | 61.1 (38.70–85.30) | 0.012 |
Sperm motility (%) | 66.90 (56.13–79.4) | 67.10 (55.9–78.3) | 0.028 | 66.55 (56.63–78.65) | 68.75 (56.90–79.10) | 0.059 |
Sperm normal morphology (%) | 5.91 (4.85–7.41) | 6.00 (4.95–7.56) | 0.122 | 5.91 (4.88–7.34) | 5.91 (4.89–7.39) | 0.020 |
Ovarian stimulation regimen | ||||||
Long GnRH agonist protocol | 192 (28.9) | 1512 (48.3) | 0.427 | 188 (35.3) | 186 (35.0) | 0.008 |
Ultra-long GnRH agonist protocol | 154 (23.2) | 174 (5.6) | 0.418 | 77 (14.5) | 83 (15.6) | 0.027 |
Short GnRH agonist protocol | 169 (25.5) | 826 (26.4) | 0.021 | 150 (28.2) | 144 (27.1) | 0.026 |
GnRH antagonist protocol | 79 (11.9) | 511 (16.3) | 0.136 | 73 (13.7) | 79 (14.8) | 0.035 |
Other | 70 (10.5) | 110 (3.5) | 0.229 | 44 (8.3) | 40 (7.5) | 0.024 |
Days of ovarian stimulation | 10 (9–12) | 10 (9–11) | 0.069 | 10 (9–12) | 10 (9–12) | 0.027 |
Gonadotrophin starting dose (IU) | 187.5 (150–225) | 150 (150–225) | 0.091 | 175 (150–225) | 175 (150–225) | 0.003 |
Total gonadotrophin dose (IU) | 2100 (1500–2913) | 1800 (1356–2475) | 0.194 | 2000 (1500–2769) | 2025 (1500–2700) | 0.010 |
Endometrial thickness on HCG trigger day (cm) | 1.10 (1.00–1.25) | 1.00 (0.90–1.20) | 0.148 | 1.10 (0.95–1.25) | 1.10 (0.95–1.20) | 0.021 |
LH level on HCG trigger day (IU) | 2.67 (1.43–5.08) | 2.66 (1.65–4.35) | 0.155 | 2.71 (1.52–4.82) | 2.73 (1.57–4.92) | 0.020 |
Oestradiol level on HCG trigger day (pg/mL) | 2341 (1421–3425) | 2825 (1802–4169) | 0.266 | 2416 (1492–3559) | 2364 (1450–3583) | 0.010 |
Progesterone level on HCG trigger day (ng/mL) | 0.81 (0.55–1.14) | 0.67 (0.46–0.97) | 0.136 | 0.80 (0.52–1.11) | 0.68 (0.46–1.00) | 0.035 |
Outcome | Endometrioma Group (n = 532) | Control Group (n = 532) | p Value |
---|---|---|---|
No. of oocytes retrieved | 7 (4–12) | 8 (4–12) | 0.336 |
MII oocytes rate | 3787/4455 (85.0) | 3996/4550 (87.8) | <0.001 |
Normal fertilization rate | 2724/4455 (61.1) | 2851/4550 (62.7) | 0.139 |
Embryo development rate on Day 2 | 1905/2724 (69.9) | 2023/2851 (71.0) | 0.402 |
Embryo development rate on Day 3 | 1061/2724 (39.0) | 1121/2851 (39.3) | 0.778 |
Good-quality embryos rate on Day 3 | 1482/2724 (54.4) | 1601/2851 (56.2) | 0.189 |
Blastocyst development rate | 1721/2724 (63.2) | 1747/2851 (61.3) | 0.143 |
Good blastocyst development rate | 1004/2724 (36.9) | 1005/2851 (35.3) | 0.212 |
Cycles cancellation rate | 199/532 (27.2) | 167/532 (23.9) | 0.149 |
Clinical pregnancy rate | 178/333 (53.5) | 191/365 (52.3) | 0.766 |
Miscarriage rate | 21/178 (11.8) | 19/191 (9.9) | 0.568 |
Live birth rate | 152/333 (45.6) | 166/365 (45.5) | 0.965 |
Outcome | Endometrioma with Surgery (n = 441) | Control Group (n = 441) | p Value |
---|---|---|---|
No. of oocytes retrieved | 7 (4–11) | 7 (4–12) | 0.657 |
MII oocytes rate | 3140/3700 (84.9) | 3255/3717 (87.6) | 0.001 |
Normal fertilization rate | 2224/3700 (60.1) | 2298/3717 (61.8) | 0.130 |
Embryo development rate on Day 2 | 1552/2224 (69.8) | 1615/2298 (70.3) | 0.717 |
Embryo development rate on Day 3 | 877/2224 (39.4) | 877/2298 (38.2) | 0.381 |
Good-quality embryos rate on Day 3 | 1239/2224 (55.7) | 1239/2298 (53.9) | 0.226 |
Blastocyst development rate | 1399/2224 (62.9) | 1425/2298 (62) | 0.535 |
Good blastocyst development rate | 830/2224 (37.3) | 864/2298 (37.6) | 0.847 |
Cycles cancellation rate | 161/441 (26.7) | 165/441 (27.2) | 0.850 |
Clinical pregnancy rate | 148/280 (52.9) | 156/276 (56.5) | 0.385 |
Miscarriage rate | 17/148 (11.5) | 14/156 (9.0) | 0.469 |
Live birth rate | 125/280 (44.6) | 141/276 (51.1) | 0.128 |
Outcome | Endometrioma with Surgery (n = 109) | Endometrioma without Surgery (n = 109) | p Value |
---|---|---|---|
No. of oocytes retrieved | 8 (5–13) | 8 (5–12) | 0.950 |
MII oocytes rate | 811/1015 (79.9) | 880/1003 (87.7) | <0.001 |
Normal fertilization rate | 560/1015 (55.2) | 664/1003 (66.2) | <0.001 |
Embryo development rate on Day 2 | 405/560 (72.3) | 453/664 (68.2) | 0.119 |
Embryo development rate on Day 3 | 237/560 (42.3) | 273/664 (41.1) | 0.670 |
Good-quality embryos rate on Day 3 | 310/560 (55.4) | 361/664 (54.4) | 0.729 |
Blastocyst development rate | 376/560 (67.1) | 400/664 (60.2) | 0.013 |
Good blastocyst development rate | 228/560 (40.7) | 234/664 (35.2) | 0.049 |
Cycles cancellation rate | 44/109 (28.8) | 36/109 (24.8) | 0.444 |
Clinical pregnancy rate | 33/65 (50.8) | 45/73 (61.6) | 0.198 |
Miscarriage rate | 2/33 (6.1) | 4/45 (8.9) | 0.974 |
Live birth rate | 30/65 (46.2) | 40/73 (54.8) | 0.311 |
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Dongye, H.; Tian, Y.; Qi, D.; Du, Y.; Yan, L. The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study. J. Clin. Med. 2023, 12, 2416. https://doi.org/10.3390/jcm12062416
Dongye H, Tian Y, Qi D, Du Y, Yan L. The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study. Journal of Clinical Medicine. 2023; 12(6):2416. https://doi.org/10.3390/jcm12062416
Chicago/Turabian StyleDongye, Houjin, Yizheng Tian, Dan Qi, Yanbo Du, and Lei Yan. 2023. "The Impact of Endometrioma on Embryo Quality in In Vitro Fertilization: A Retrospective Cohort Study" Journal of Clinical Medicine 12, no. 6: 2416. https://doi.org/10.3390/jcm12062416