Switching to Intravitreal Brolucizumab after Ranibizumab or Aflibercept Using Treat and Extend Regimen for Neovascular Age-Related Macular Degeneration in Japanese Patients: 1-Year Results and Factors Associated with Treatment Responsiveness
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Treatment Protocol
2.3. Outcome Measures
2.4. Statistical Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristics | |
---|---|
Number of cases (patients), n | 36 (35) |
Male, n (%) | 28 (82) |
Age (years), mean | 78.3 ± 6.3 |
Disease subtype, n (%) | |
Type 1 MNV | 20 (56) |
Type 2 MNV | 1 (3) |
PCV | 15 (42) |
Time interval from initial treatment (month), mean | 57.6 ± 35.3 |
Previous treatment | |
Number of total anti-VEGF therapy sessions, mean | 27.2 ± 19.4 |
History of ranibizumab, n (%) | 9 (25) |
Number of ranibizumab, mean | 16.2 ± 11.6 |
History of aflibercept, n (%) | 33 (92) |
Number of aflibercept treatments, mean | 22.8 ± 14.8 |
History of PDT, n (%) | 17 (47) |
Number of PDT sessions, mean | 2.8 ± 2.2 |
BCVA (logMAR), mean | 0.40 ± 0.27 |
CMT (µm), mean | 212 ± 107 |
CCT (µm), mean | 205 ± 105 |
Characteristics | Good Response | Poor Response | p Value |
---|---|---|---|
Number, n | 18 | 18 | 0.114 |
Male, n (%) | 16 (89) | 12 (67) | 0.917 |
Age (years), mean | 78 | 79 | 0.091 |
Presence of PCV, n (%) | 5 (28) | 10 (56) | 0.059 |
Number of anti-VEGF therapy sessions, mean | 21.1 | 33.3 | 0.317 |
History of PDT, n (%) | 7 (39) | 10 (56) | 0.174 |
Time interval from initial treatment (month), mean | 50 | 66 | 0.340 |
Treatment before switching (aflibercept), n (%) | 13 (72) | 17 (94) | 0.089 |
BCVA (logMAR), mean | 0.37 | 0.43 | 0.252 |
CMT (µm), mean | 232 | 191 | 0.061 |
CCT (µm), mean | 172 | 237 | 0.114 |
Univariate | Multivariate | |||||
---|---|---|---|---|---|---|
OR | 95%CI | p Value | OR | 95%CI | p Value | |
Sex (male) | 4.000 | 0.684–23.406 | 0.124 | |||
Age (years) | 0.994 | 0.894–1.105 | 0.914 | |||
Presence of PCV | 0.308 | 0.077–1.234 | 0.096 | |||
Number of anti-VEGF therapy sessions | 0.964 | 0.926–1.003 | 0.071 | 0.947 | 0.903–0.994 | 0.028 |
History of PDT | 0.509 | 0.135–1.920 | 0.319 | |||
Time interval from initial treatment | 0.986 | 0.967–1.006 | 0.172 | |||
Treatment before switching (aflibercept) | −0.298 | −0.846–0.046 | 0.077 | |||
BCVA (0.3≥) | 2.080 | 0.519–8.339 | 0.301 | |||
CMT (200 µm≤) | 1.250 | 0.337–4.636 | 0.739 | |||
CCT (250 µm≤) | 0.196 | 0.034–1.129 | 0.068 | 0.099 | 0.013–0.731 | 0.023 |
No | Sex | Age | Complications | Treatment | Time to Onset | Treatment | Final Status | BCVA | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Initial Treatment | Before Switching | Initial Treatment | First IVBR | (Around the Onset) | ||||||||
(Month) | (Day) | Before | After | Final | ||||||||
1 | M | 87 | AC | IVA | IVA | 19 | 55 | No | recovered | 0.7 | 0.6 | 0.7 |
2 | M | 72 | VC | IVA | IVA | 72 | 34 | No | recovered | 0.3 | 0.4 | 0.3 |
3 | F | 75 | VC | IVA | IVA | 43 | 27 | 0.1% FLM | recovered | 0.4 | 0.4 | 0.4 |
4 | M | 76 | AC | IVA | IVA | 52 | 55 | No | recovered | 0.15 | 0.15 | 0.1 |
RO | 55 | 139 | Oral PSL, 0.1% BMS | improved | 0.1 | 0.1 | 0.1 | |||||
5 | M | 84 | AC | PDT-IVR | IVA | 93 | 10 | 0.1% BMS | recovered | 0.2 | 0.2 | 0.2 |
6 | F | 75 | AC | IVA | IVA | 21 | 70 | No | recovered | 0.4 | 0.6 | 0.6 |
7 | M | 82 | RO | IVR | IVA | 113 | 67 | Oral PSL, 0.1% BMS | improved | 0.06 | 0.07 | 0.06 |
8 | F | 74 | AC, VH | IVR | IVA | 126 | 127 | 0.1% BMS | recovered | 0.7 | 0.6 | 0.6 |
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Hirayama, K.; Yamamoto, M.; Honda, S.; Kyo, A.; Misawa, N.; Kohno, T. Switching to Intravitreal Brolucizumab after Ranibizumab or Aflibercept Using Treat and Extend Regimen for Neovascular Age-Related Macular Degeneration in Japanese Patients: 1-Year Results and Factors Associated with Treatment Responsiveness. J. Clin. Med. 2024, 13, 4375. https://doi.org/10.3390/jcm13154375
Hirayama K, Yamamoto M, Honda S, Kyo A, Misawa N, Kohno T. Switching to Intravitreal Brolucizumab after Ranibizumab or Aflibercept Using Treat and Extend Regimen for Neovascular Age-Related Macular Degeneration in Japanese Patients: 1-Year Results and Factors Associated with Treatment Responsiveness. Journal of Clinical Medicine. 2024; 13(15):4375. https://doi.org/10.3390/jcm13154375
Chicago/Turabian StyleHirayama, Kumiko, Manabu Yamamoto, Shigeru Honda, Akika Kyo, Norihiko Misawa, and Takeya Kohno. 2024. "Switching to Intravitreal Brolucizumab after Ranibizumab or Aflibercept Using Treat and Extend Regimen for Neovascular Age-Related Macular Degeneration in Japanese Patients: 1-Year Results and Factors Associated with Treatment Responsiveness" Journal of Clinical Medicine 13, no. 15: 4375. https://doi.org/10.3390/jcm13154375
APA StyleHirayama, K., Yamamoto, M., Honda, S., Kyo, A., Misawa, N., & Kohno, T. (2024). Switching to Intravitreal Brolucizumab after Ranibizumab or Aflibercept Using Treat and Extend Regimen for Neovascular Age-Related Macular Degeneration in Japanese Patients: 1-Year Results and Factors Associated with Treatment Responsiveness. Journal of Clinical Medicine, 13(15), 4375. https://doi.org/10.3390/jcm13154375