From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach
Abstract
:1. Introduction
- (a)
- We first review the existing body of research on memory performance within the realm of OCD. Following this, we introduce a pivotal concept—the EBL classification system [43]—which combines executive function (E), binding complexity (B), and memory load (L) to provide a framework for examining memory impairments in OCD. We highlight its empirical basis and its ability to address various task requirements in elucidating the occurrence, absence, and extent of memory deficits in individuals with OCD. However, while EBL provides valuable insights, we also recognise its limitations, including its theoretical framework and the difficulty in quantifying its dimensions.
- (b)
- To address these limitations, we then elucidate how we used the mi-MA approach [38] to quantify the impact of task demands in terms of E, B, and L dimensions on the memory performance of those with OCD. We contend that this offers a more thorough comprehension of how these factors interact with memory performance in OCD than was previously achievable.
- (c)
- We then delve into our refined analysis of specific facets of executive control [39], analysing the impacts of top-down and bottom-up processing, and their individual roles in memory performance in OCD, we underscore how our mi-MA approach enabled us to measure these processes in OCD, a novel approach not previously explored in the literature.
- (d)
- As our paper nears its conclusion, we reiterate the significance of our findings and underscore the importance of research that addresses the clinical relevance of cognitive factors in OCD. By leveraging the wealth of existing research and integrating their findings through an mi-MA lens, we then propose novel insights into the cognitive processes of OCD and inform the development of more effective interventions. We hope that our approach serves to address Ouimet et al.’s [44] critique of cognitive research in OCD, which states that “simply explaining the cognitive phenomenology of OCD without a direct view towards enhancing its clinical relevance, although interesting, is unlikely to be helpful” (p. 26).
2. Memory Performance in OCD: Insights from Mixed Findings and the EBL Classification System
3. Quantifying the EBL Classification System through a Multidimensional Meta-Analysis
Main Steps for Conducting a Multidimensional Meta-Analysis |
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4. Executive Functioning and Memory Performance in OCD: A Second More Refined Multidimensional Meta-Analysis
5. Enhancing Clinical Relevance: Insights from a Multimodal Meta-Analysis Perspective
6. Bridging Research and Practice: Insights from a Multimodal Meta-Analysis Perspective
6.1. Targeted Interventions for Cognitive Dysfunction in OCD: Bridging Theory to Practice
6.2. Labelling—An Intervention in Faulty Sensory Gating
6.3. Input-Gating Policies—An Intervention in Faulty WM Gating
6.4. Beyond Efficacy: Targets and Mechanisms of OCD Interventions Using mi-MA
Funding
Conflicts of Interest
References
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Harkin, B.; Yates, A. From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach. J. Clin. Med. 2024, 13, 4629. https://doi.org/10.3390/jcm13164629
Harkin B, Yates A. From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach. Journal of Clinical Medicine. 2024; 13(16):4629. https://doi.org/10.3390/jcm13164629
Chicago/Turabian StyleHarkin, Ben, and Alan Yates. 2024. "From Cognitive Function to Treatment Efficacy in Obsessive–Compulsive Disorder: Insights from a Multidimensional Meta-Analytic Approach" Journal of Clinical Medicine 13, no. 16: 4629. https://doi.org/10.3390/jcm13164629