Local Antibiotic Infusion in Periprosthetic Joint Infection Following Total Hip Arthroplasty
Abstract
:1. Introduction
2. Materials and Methods
3. Theoretical Basis of the Local Antibiotic Infusion in PJI Management
4. Adjuvant Local Antibiotic Infusion in Each Treatment Procedure for PJI Following THA
5. Intra-Articular Infusion Technique
6. Efficacy of DAIR Combined with Local Antibiotic Infusion
7. Efficacy of Single-Stage Revision Arthroplasty Combined with Local Antibiotic Infusion
8. Efficacy of Two-Stage Revision Arthroplasty Combined with Local Antibiotic Infusion
9. Future Directions
10. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors (Year) | Country | PJI Location | Surgical Treatment Procedure | No. of Patients * | Organisms | Local Infusion Protocol | Catheter Used for Local Infusion | Duration of Local Infusion |
---|---|---|---|---|---|---|---|---|
Antony et al. (2015) [16] | USA | Hip, knee, elbow | Single-stage | 20 | Gram-positive bacteria, Gram-negative bacteria, culture-negative infection, fungus, multidrug-resistant organisms |
| Hickman catheter | 4–6 weeks |
Gillard-Campbell et al. (2021) [17] | USA | Hip, knee | Two-stage | 5 | Not reported | Vancomycin and cefazolin | Hickman catheter | 6 weeks |
Catheterization infusion | 7 | |||||||
Ji et al. (2019) [18] | China | Hip | Single-stage | 50 | Culture-negative infection, fungus, multidrug-resistant and polymicrobial organisms |
| Not reported |
|
Ji et al. (2020) [19] | China | Hip, knee | Single-stage | 99 | Culture-negative infection, fungus, multidrug-resistant organisms |
| Three-branch catheter |
|
Ji et al. (2022) [20] | China | Hip, knee | Single-stage | 29 | Gram-positive bacteria, Gram-negative bacteria, fungus, culture-negative infection, multidrug-resistant and polymicrobial organisms |
| Three-branch catheter | Mean 16 days (range 12–21 days) |
Li et al. (2022) [21] | China | Hip, knee | Single-stage | 69 | Gram-positive bacteria, Gram-negative bacteria, fungus, multidrug-resistant and polymicrobial organisms |
| Three-branch catheter |
|
Li et al. (2023) [22] | China | Hip, knee | Single-stage | 22 | Gram-negative bacteria and polymicrobial organisms |
| Three-branch catheter |
|
Mu et al. (2020) [11] | China | Hip, knee | DAIR | 32 | Gram-positive bacteria, Gram-negative bacteria, fungus, culture-negative infection, multidrug-resistant and polymicrobial organisms |
| Three-branch catheter |
|
Springer et al. (2024) [23] | USA | Hip, knee | Two-stage | 14 | Not reported | Tobramycin and vancomycin | Irrigation line connected to a short-term implantable spacer (VT-X7) | 7 days |
Whiteside and Roy (2017) [24] | USA | Hip | Single-stage | 21 | Gram-positive bacteria, Gram-negative bacteria, fungus, multidrug-resistant organisms |
| Hickman catheter | 6 weeks |
DAIR | 9 |
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Jarusriwanna, A.; Mu, W.; Parvizi, J. Local Antibiotic Infusion in Periprosthetic Joint Infection Following Total Hip Arthroplasty. J. Clin. Med. 2024, 13, 4848. https://doi.org/10.3390/jcm13164848
Jarusriwanna A, Mu W, Parvizi J. Local Antibiotic Infusion in Periprosthetic Joint Infection Following Total Hip Arthroplasty. Journal of Clinical Medicine. 2024; 13(16):4848. https://doi.org/10.3390/jcm13164848
Chicago/Turabian StyleJarusriwanna, Atthakorn, Wenbo Mu, and Javad Parvizi. 2024. "Local Antibiotic Infusion in Periprosthetic Joint Infection Following Total Hip Arthroplasty" Journal of Clinical Medicine 13, no. 16: 4848. https://doi.org/10.3390/jcm13164848